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6.3.2.24: tyrosine-arginine ligase

This is an abbreviated version!
For detailed information about tyrosine-arginine ligase, go to the full flat file.

Word Map on EC 6.3.2.24

Reaction

ATP
+
L-tyrosine
 +
L-arginine
=
AMP
 +
diphosphate
 +
L-tyrosyl-L-arginine

Synonyms

KTP synthetase, kyotorphin synthase, kyotorphin synthetase, kyotorphin-synthesizing enzyme, synthetase, kyotorphin, tyrosyl-arginine synthase, TyrRS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.24 tyrosine-arginine ligase

Substrates Products

Substrates Products on EC 6.3.2.24 - tyrosine-arginine ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + L-tyrosine + L-arginine
L-tyrosyl-L-arginine + ?
show the reaction diagram
-
-
37.8% of activity compared to ATP
?
AMP + L-tyrosine + L-arginine
L-tyrosyl-L-arginine + ?
show the reaction diagram
-
-
1,6% of activity compared to ATP
?
ATP + L-arginine + leucine
? + AMP
show the reaction diagram
-
-
3.5% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-arginine + lysine
? + AMP
show the reaction diagram
-
-
10.3% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-arginine + phenylalanine
? + AMP
show the reaction diagram
-
-
10% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-arginine + tryptophan
? + AMP
show the reaction diagram
-
-
11.3% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-tyrosine + glutamate
? + AMP
show the reaction diagram
-
-
26.1% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-tyrosine + glycine
? + AMP
show the reaction diagram
-
-
1.1% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-tyrosine + histidine
? + AMP
show the reaction diagram
-
-
4.0% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-tyrosine + L-arginine
AMP + diphosphate + L-tyrosyl-L-arginine
show the reaction diagram
ATP + L-tyrosine + L-arginine
L-tyrosyl-L-arginine + AMP + diphosphate
show the reaction diagram
ATP + L-tyrosine + leucine
? + AMP
show the reaction diagram
-
-
31.4% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
ATP + L-tyrosine + lysine
? + AMP
show the reaction diagram
-
-
14.3% the rate of AMP formed by ATP/L-tyrosine/L-arginine
?
GTP + L-tyrosine + L-arginine
L-tyrosyl-L-arginine + ?
show the reaction diagram
-
-
20.2% of activity compared to ATP
?
additional information
?
-