6.3.2.23: homoglutathione synthase

This is an abbreviated version!
For detailed information about homoglutathione synthase, go to the full flat file.

Reaction

Synonyms

beta-alanine specific hGSH synthetase, hGS, hGSH synthetase, hGSH-synthetase, hGSHS, homoglutathione synthetase, synthetase, homoglutathione

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.23 homoglutathione synthase

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Results	in table
6	Activating Compound
6	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
3	Expression
3	General Information
7	Inhibitors
10	kcat/KM [mM/s]
20	KM Value [mM]
17	Localization
8	Metals/Ions
5	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
25	Organism
1	Pathway
2	PDB ID
5	pH Optimum
1	pH Range
6	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
24	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
31	Substrates and Products (Substrate)
4	Subunits
19	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.2.23 - homoglutathione synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

9 entries

ATP + gamma-L-glutamyl-L-cysteine + L-serine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-L-serine

Medicago truncatula

-

-

728585

-

-

?

additional information

?

-

3 entries

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Glycine max

-

transgenic tobacco plants expressing homoglutathione synthase in the cytosol exhibit tolerance to acifluorfen but not to fomesafen, those expressing the enzyme in chloroplasts exhibit no enhanced tolerance to acifluorfen or fomesafen

663073

-

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Lotus japonicus

-

-

728056

i.e. homo-glutathione

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Medicago sativa

-

-

728056

i.e. homo-glutathione

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Medicago truncatula

-

-

728585

-

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Medicago truncatula

-

deficiency on GSH and hGSH synthesis inhibits the formation of the root nodule

662922

-

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Phaseolus coccineus

-

-

648901

-

648901

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Phaseolus vulgaris

-

-

694711

-

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Phaseolus vulgaris

-

-

728056

i.e. homo-glutathione

-

?

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine

ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

Vigna radiata var. radiata

-

-

1185

i.e. homoglutathione

1185

?

additional information

?

-

Medicago sativa

-

exposition of plants to drought results in down-regulation of homoglutathione synthetase

676633

-

-

?

additional information

?

-

Medicago truncatula

-

hGSH synthetase found in plants is much more specific for beta-Ala, although it also accepts Gly as a substrate

728585

-

-

?

additional information

?

-

Phaseolus vulgaris

-

regulation of ascorbate and homoglutathione biosynthesis in common bean nodules under stress conditions and during aging, the homoglutathione synthetase expression and activity is not affected by stress. During senescence in the first stage ascorbate decreases by 60%, while homoglutathione and antioxidant activities remain fairly constant,whereas in the second stage ascorbate and homoglutathione, their redox states, and their associated enzyme activities significantly decrease, overview

694711

-

-

?