6.3.2.23: homoglutathione synthase

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For detailed information about homoglutathione synthase, go to the full flat file.

Reaction

Synonyms

beta-alanine specific hGSH synthetase, hGS, hGSH synthetase, hGSH-synthetase, hGSHS, homoglutathione synthetase, synthetase, homoglutathione

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.23 homoglutathione synthase

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Results	in table
6	Activating Compound
6	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
3	Expression
3	General Information
7	Inhibitors
10	kcat/KM [mM/s]
20	KM Value [mM]
17	Localization
8	Metals/Ions
5	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
25	Organism
1	Pathway
2	PDB ID
5	pH Optimum
1	pH Range
6	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
24	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
31	Substrates and Products (Substrate)
4	Subunits
19	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]

Engineering

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Engineering on EC 6.3.2.23 - homoglutathione synthase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

L487A

Glycine max

-

improved catalytic efficiency using glcyine

706219

L487A/P488A

Glycine max

-

conversion of substrate preference from beta-alanine to glycine

706219

P488A

Glycine max

-

improved catalytic efficiency using glcyine

706219

L534A

Medicago truncatula

Q9XEB8

increased production of glutathione and reduced formation of homglutathione

648904

L534A/P535A

2 entries

L534A/P535A

Medicago truncatula

Q9XEB8

as compared with L534A mutant, even further increased production of glutathione and further reduced formation of homglutathione

648904

L534A/P535A

Medicago truncatula

-

site-directed mutagenesis, the mutant shows properties similar to GSH synthetase, EC 6.3.2.3. A534 and A535 are conserved in glutathione synthetase

728585