6.3.2.2: glutamate-cysteine ligase

This is an abbreviated version!
For detailed information about glutamate-cysteine ligase, go to the full flat file.

Reaction

Synonyms

Ace-GCL, Asuc_1947, AtGCL, bifunctional glutathione synthetase, bifunctional GSH synthetase, bifunctional L-glutathione synthetase, gamma -GCS, gamma-ECL, Gamma-ECS, gamma-GC, gamma-GCS, gamma-GCS-GS, gamma-glutamate-cysteine ligase-glutathione synthetase, gamma-glutamate-cysteine ligase/glutathione synthetase, gamma-glutaminylcysteine synthetase, gamma-glutamycysteine synthetase, gamma-glutamyl-cysteine ligase, gamma-Glutamyl-L-cysteine synthetase, gamma-glutamylcysteine ligase, gamma-glutamylcysteine synthase, gamma-Glutamylcysteine synthetase, gamma-glutamylcysteine synthetase-glutathione synthetase, gamma-Glutamylcysteinyl-synthetase, gammaGCS, GCL, GCLC, Gclc-X2, GCLM, GCS, GCSGS, ghF, GLCL, GLCLC, GLCLR, glutamate cysteine ligase, glutamate cysteine ligase gene, glutamate-cysteine ligase, glutamate-cysteine-ligase, glutamate�cysteine ligase, glutathione biosynthesis bifunctional protein GshAB, GSH1, GshA, gshAB, GshF, GshFAp, GshFAs, GSHI, I79_022778, L-glutamate L-cysteine ligase, More, PAD2, PhGshA II, PSHAa0937, StGCL-GS, Synthetase, gamma-glutamylcysteine

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.2 glutamate-cysteine ligase

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Results	in table
88	Activating Compound
40157	AA Sequence
26	Application
1	CAS Registry Number
88	Cloned(Commentary)
92	Cofactor
6	Crystallization (Commentary)
1372	Disease/ Diagnostics
20	Expression
56	General Information
23	General Stability
13	IC50 Value
275	Inhibitors
40	kcat/KM [mM/s]
84	Ki Value [mM]
336	KM Value [mM]
34	Localization
69	Metals/Ions
81	Molecular Weight [Da]
148	Natural Substrates/ Products (Substrates)
1297	Organism
9	Pathway
33	PDB ID
38	pH Optimum
2	pH Range
2	pH Stability
3	pI Value
16	Posttranslational Modification
127	Protein Variants
50	Purification (Commentary)
23	Reaction
5	Reaction Type
246	Reference
203	Source Tissue
73	Specific Activity [micromol/min/mg]
24	Storage Stability
450	Substrates and Products (Substrate)
116	Subunits
322	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
108	Turnover Number [1/s]

Organism

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Organism on EC 6.3.2.2 - glutamate-cysteine ligase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acidithiobacillus ferrooxidans

-

649263

Q56277

SwissProt

brenda

Actinobacillus pleuropneumoniae

-

744122

D4N892

UniProt

brenda

Actinobacillus succinogenes

-

744122

A6VQP8

UniProt

brenda

Actinobacillus succinogenes ATCC 55618

-

744122

A6VQP8

UniProt

brenda

Agrobacterium tumefaciens

-

694674

-

-

brenda

Anas platyrhynchos

mallard duck

692058

-

-

brenda

Ancylostoma ceylanicum

genes GCLC and GCLM encoding catalytic heavy chain subunit and modifier light chain subunits

745734

C1KBE8; C1KBE7

UniProt

brenda

Arabidopsis sp.

-

676524

-

-

brenda

Arabidopsis thaliana

3 entries

Ascaris suum

-

1140, 649263

-

-

brenda

Bacterium cadaveris

-

1126

-

-

brenda

Bos taurus

-

1131, 1137, 649263

-

-

brenda

Brassica juncea

-

674643, 694674

O23736

Uniprot

brenda

Cricetulus griseus

genes I79_010621 and I79_022778 encoding catalytic and regulatory subunits

744552

G3HIY9; G3IG96

UniProt

brenda

Drosophila melanogaster

3 entries

Escherichia coli

10 entries

Escherichia coli B / ATCC 11303

2 entries

Escherichia coli Crooks

-

1126

-

-

brenda

Escherichia coli FKU-1

-

1126

-

-

brenda

Escherichia coli FKU-3

-

1126

-

-

brenda

Escherichia coli FKU-8

-

1126

-

-

brenda

Escherichia coli JM109

-

652341

P0A6W9

SwissProt

brenda

Escherichia coli K-10

-

1126

-

-

brenda

Escherichia coli S-96

-

1126

-

-

brenda

Exaiptasia diaphana

symbiotic sea anemone, genes gclC and gclM encoding the catalytic and the modifier subunits of the enzyme

691909

B2ZG39

UniProt

brenda

Haloferax volcanii

-

704303

D4GZN2

UniProt

brenda

Homo sapiens

16 entries

Klebsiella aerogenes

-

1126

-

-

brenda

Leishmania donovani

-

716002

-

-

brenda

Leishmania infantum

-

705790

-

-

brenda

Leishmania tarentolae

-

649263

P90557

SwissProt

brenda

Leuconostoc kimchii

gene gshA

690718

-

-

brenda

Leuconostoc kimchii KTCC 2386

gene gshA

690718

-

-

brenda

Leuconostoc mesenteroides

strain ATCC8293, gene gshA

690718

-

-

brenda

Leuconostoc mesenteroides ATCC 8293

strain ATCC8293, gene gshA

690718

-

-

brenda

Mus musculus

11 entries

Nicotiana tabacum

2 entries

no activity in Entamoeba histolytica

-

649263

-

-

brenda

no activity in Giardia sp.

-

649263

-

-

brenda

Nostoc sp.

PCC 7120

663074

-

-

brenda

Onchocerca volvulus

-

653171

Q9NFN6

SwissProt

brenda

Ovis aries

-

1128, 649263

-

-

brenda

Pasteurella multocida

-

662457

-

-

brenda

Peromyscus maniculatus

-

703432

-

-

brenda

Phragmites australis

-

706167

-

-

brenda

Pisum sativum

-

1149

-

-

brenda

Plasmodium berghei

-

706061

-

-

brenda

Populus tremula x Populus alba

2 entries

Proteus mirabilis

-

1126, 649263

-

-

brenda

Proteus vulgaris

-

1126

-

-

brenda

Pseudoalteromonas haloplanktis

-

744438

Q3IEB7

UniProt

brenda

Pseudoalteromonas haloplanktis TAC 125

-

744438

Q3IEB7

UniProt

brenda

Pseudomonas aeruginosa

-

1126

-

-

brenda

Pseudomonas fluorescens

-

1126

-

-

brenda

Pseudomonas schuylkilliensis

-

1126

-

-

brenda

Rattus norvegicus

18 entries

Rattus norvegicus Sprague-Dawley

-

726668

-

-

brenda

Rhodotorula diobovata

-

745888

A0A0U2SCI4

UniProt

brenda

Rhodotorula diobovata MCCC 2A00023

-

745888

A0A0U2SCI4

UniProt

brenda

Saccharomyces cerevisiae

4 entries

Schizosaccharomyces pombe

2 entries

Spinacia oleracea

-

1149

-

-

brenda

Streptococcus agalactiae

-

662339, 672053

-

-

brenda

Streptococcus agalactiae serogroup V

-

744070

Q8DXM9

UniProt

brenda

Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R

-

744070

Q8DXM9

UniProt

brenda

Streptococcus thermophilus

6 entries

Streptococcus thermophilus SIIM B218

2 entries

Sus scrofa

-

649263

-

-

brenda

Synechocystis sp.

gene gshA or slr0990

726912

P74515

UniProt

brenda

Triticum aestivum

-

1149

-

-

brenda

Trypanosoma brucei

3 entries

Unio tumidus

fragment

691912

B4YE15

UniProt

brenda

Xanthomonas campestris

-

694674

-

-

brenda

Xenopus laevis

-

1135

-

-

brenda

Xenopus sp.

-

649263

-

-

brenda

Zea mays

-

663122

Q8W4W3

Uniprot

brenda

[Candida] boidinii

-

649263

-

-

brenda

Arabidopsis thaliana

-

1142

-

-

brenda

Arabidopsis thaliana

-

649263, 662247

P46309

SwissProt

brenda

Arabidopsis thaliana

-

676435, 676610, 694060

-

-

brenda

Drosophila melanogaster

-

652480, 662424

-

-

brenda

Drosophila melanogaster

-

672367

Q9W3K5

SwissProt

brenda

Drosophila melanogaster

-

694060

-

-

brenda

Escherichia coli

-

1120, 1126, 1127, 1141, 650595, 650634

-

-

brenda

Escherichia coli

-

652341

P0A6W9

SwissProt

brenda

Escherichia coli

-

663215, 702759, 706163

-

-

brenda

Escherichia coli

-

745900

P0A6W9

SwissProt

brenda

Escherichia coli

B

649189

-

-

brenda

Escherichia coli

enriched by recombinant DNA techniques in its content of gamma-glutamylcysteine synthetase, strain W, strain KM

1118

-

-

brenda

Escherichia coli

gene gshA

726910

-

-

brenda

Escherichia coli

K12, strain W3110, gene gshI

651813

-

-

brenda

Escherichia coli

strain W, strain B, strain KM

649263

P0A6W9

SwissProt

brenda

Escherichia coli

wild-type and mutant enzyme His150Ala

1141

-

-

brenda

Escherichia coli B / ATCC 11303

-

1120, 1126, 1127, 1141

-

-

brenda

Escherichia coli B / ATCC 11303

B

649189

-

-

brenda

Homo sapiens

-

1143, 649413, 649655, 649660, 650713, 651391, 651996, 653714, 653993, 661855

-

-

brenda

Homo sapiens

-

662512

P48506

SwissProt

brenda

Homo sapiens

-

671216, 671223, 672904, 674140, 675918, 676099, 692442, 692444, 694609, 703592, 703799, 704577, 704665, 704751, 705264, 705828, 706834, 714265, 715088, 716235, 726668

-

-

brenda

Homo sapiens

2 subunits encoded by 2 genes

651393

-

-

brenda

Homo sapiens

activity of the gamma-glutamylcysteine synthetase promoter decreases after indomethacin treatment

702998

-

-

brenda

Homo sapiens

enzyme consists of a catalytic GCLC and a modulatory GCLM subunit encoded by 2 separate gcl genes

651392

-

-

brenda

Homo sapiens

gene gclC and gclM encoding the two subunits of the enzyme

690387

-

-

brenda

Homo sapiens

genes GCLC and GCLM encoding catalytic and modifier subunits

744853, 745934

P48506; P48507

UniProt

brenda

Homo sapiens

genes GCLC and GCLM encoding heavy and light chain subunits

744469

P48506; P48507

UniProt

brenda

Homo sapiens

genes gclC and gclM encoding the two subunits of the enzyme

690385, 690630, 694060

-

-

brenda

Homo sapiens

healthy individuals and chronic obstructive pulmonary disease patients, genes gclC and gclM encoding the two subunits of the enzyme

692205

-

-

brenda

Homo sapiens

heavy, catalytic subunit

649263

P48506

SwissProt

brenda

Homo sapiens

Japanese individuals and patients with methamphetamine dependence and induced psychosis, genes gclC and gclM encoding the catalytic and the modifier subunit of the enzyme

690440

-

-

brenda

Homo sapiens

leukemia cell. Cells show increased expression of gamma-glutamylcysteine synthetase. Expression decreases by indomethacin treatment

702998

-

-

brenda

Homo sapiens

light, regulatory subunit

649263

P48507

SwissProt

brenda

Homo sapiens

patients with non-alcoholic steatohepatitis

704911

-

-

brenda

Mus musculus

-

1145, 652979, 660892, 661811, 662412, 663372, 671927

-

-

brenda

Mus musculus

-

672367

P97494

SwissProt

brenda

Mus musculus

-

674653, 676160, 703091, 703807, 704707, 706087, 706829, 715088, 726668, 727274

-

-

brenda

Mus musculus

2 subunits encoded by 2 genes

651393

-

-

brenda

Mus musculus

deer mice

692058

-

-

brenda

Mus musculus

gene gclC and gclM, encoding the catalytic and the modifier subunit

692055

-

-

brenda

Mus musculus

genes gclC and gclM

690677

-

-

brenda

Mus musculus

genes GCLC and GCLM encoding catalytic heavy chain subunit and modifier light chain subunits

745805

P97494; O09172

UniProt

brenda

Mus musculus

genes gclC and gclM encoding the two subunits of the enzyme

694060

-

-

brenda

Mus musculus

heavy, catalytic subunit

649263

P97494

SwissProt

brenda

Mus musculus

light, regulatory subunit

649263

A0A0H2UNM8

UniProt

brenda

Nicotiana tabacum

-

1149, 649263

-

-

brenda

Nicotiana tabacum

-

694674

Q1W2L8

Uniprot

brenda

Populus tremula x Populus alba

hybrid, INRA-clone Nr. 717-1-B4

652649

-

-

brenda

Populus tremula x Populus alba

wild-type and overexpressing gamma-glutamylcysteine synthetase

662540

-

-

brenda

Rattus norvegicus

-

1118, 1119, 1121, 1122, 1123, 1124, 1125, 1129, 1130, 1132, 1133, 1134, 1135, 1136, 1138, 1139, 1144, 1147, 1150, 649315, 652304

-

-

brenda

Rattus norvegicus

-

660680

P19468

SwissProt

brenda

Rattus norvegicus

-

661014

-

-

brenda

Rattus norvegicus

-

662512

P19468

SwissProt

brenda

Rattus norvegicus

-

663435, 673803, 703167, 704924, 706835, 706846, 715084, 726668

-

-

brenda

Rattus norvegicus

2 subunits encoded by 2 genes

651393

-

-

brenda

Rattus norvegicus

catalytic subunit

706830

P19468

SwissProt

brenda

Rattus norvegicus

female Sprague-Dawley rats

694485

-

-

brenda

Rattus norvegicus

genes GCLC and GCLM encoding heavy and light chain subunits

744165

P19468; P48508

UniProt

brenda

Rattus norvegicus

genes gclC and gclM encoding the two subunits of the enzyme

694060

-

-

brenda

Rattus norvegicus

heavy, catalytic subunit

649263

P19468

SwissProt

brenda

Rattus norvegicus

light, regulatory subunit

649263

P48508

SwissProt

brenda

Rattus norvegicus

male F344 rats

649525

-

-

brenda

Rattus norvegicus

male Lewis rats

653987

-

-

brenda

Rattus norvegicus

male sprague-dawley rats

650330

-

-

brenda

Rattus norvegicus

male Wistar rats, genes GCLC and GCLM

692437

-

-

brenda

Rattus norvegicus

Sprague-Dawley rats

692058

-

-

brenda

Rattus norvegicus

Sprague-Dawley rats, female

694485

P19468

SwissProt

brenda

Saccharomyces cerevisiae

-

649263

P32477

SwissProt

brenda

Saccharomyces cerevisiae

-

661378

-

-

brenda

Saccharomyces cerevisiae

-

704577, 704660

P32477

SwissProt

brenda

Saccharomyces cerevisiae

gene GSH1

651393, 653272

-

-

brenda

Schizosaccharomyces pombe

-

1146

-

-

brenda

Schizosaccharomyces pombe

-

649263

Q09768

SwissProt

brenda

Streptococcus thermophilus

-

706151

D7P1H2

UniProt

brenda

Streptococcus thermophilus

-

744070

D4N891

UniProt

brenda

Streptococcus thermophilus

-

745490

D7P1H2

UniProt

brenda

Streptococcus thermophilus

-

745492

D4N891

UniProt

brenda

Streptococcus thermophilus

-

745745

D7P1H2

UniProt

brenda

Streptococcus thermophilus

bifunctional glutamate-cysteine ligase and glutathione synthetase

715700

D4N891

UniProt

brenda

Streptococcus thermophilus SIIM B218

-

744070, 745492

D4N891

UniProt

brenda

Streptococcus thermophilus SIIM B218

bifunctional glutamate-cysteine ligase and glutathione synthetase

715700

D4N891

UniProt

brenda

Trypanosoma brucei

-

1148

-

-

brenda

Trypanosoma brucei

-

649263

Q26820

SwissProt

brenda

Trypanosoma brucei

-

650135, 651896, 652192

-

-

brenda