6.3.2.18: gamma-glutamylhistamine synthase

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For detailed information about gamma-glutamylhistamine synthase, go to the full flat file.

Reaction

Synonyms

gamma-GHA synthetase, gamma-Glutamylhistamine synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.18 gamma-glutamylhistamine synthase

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2	KM Value [mM]
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2	Natural Substrates/ Products (Substrates)
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1	pH Optimum
1	pH Range
1	Reaction
2	Reference
7	Source Tissue
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Substrates Products

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Substrates Products on EC 6.3.2.18 - gamma-glutamylhistamine synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + L-glutamate + histamine

products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine

Aplysia californica

-

-

1102

-

-

?

additional information

?

-

Aplysia californica

-

D-glutamate is 5% as effective as the L-isomer. The HA-acceptor activity of glutamine, glutathione, and alpha-L-glutamyl-L-alanine is 1/50 that of L-glutamate. L-aspartate is used as substrate at 1% the rate of L-glutamate

1102

-

-

?