6.3.2.18: gamma-glutamylhistamine synthase

This is an abbreviated version!
For detailed information about gamma-glutamylhistamine synthase, go to the full flat file.

Reaction

Synonyms

gamma-GHA synthetase, gamma-Glutamylhistamine synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.18 gamma-glutamylhistamine synthase

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Results	in table
1	Activating Compound
1	Cofactor
12	Inhibitors
2	KM Value [mM]
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
2	Organism
1	pH Optimum
1	pH Range
1	Reaction
2	Reference
7	Source Tissue
2	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]

Inhibitors

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Inhibitors on EC 6.3.2.18 - gamma-glutamylhistamine synthase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5-hydroxytryptamine

Aplysia californica

-

effective inhibitor, 1 mM inhibits Nalpha-gamma-L-glutamylhistamine synthesis by 92%

1102

5-methoxytryptamine

Aplysia californica

-

1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 87%

1102

DL-octopamine

Aplysia californica

-

effective inhibitor, 1 mM inhibits Nalpha-gamma-L-glutamylhistamine synthesis by 91%

1102

dopamine

Aplysia californica

-

effective inhibitor, 1 mM inhibits Nalpha-gamma-L-glutamylhistamine synthesis by 84%

1102

gamma-aminobutyric acid

Aplysia californica

-

1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 13%

1102

L-norepinephrine

Aplysia californica

-

1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 73%

1102

N-acetylserotonin

Aplysia californica

-

1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 11%

1102

noradrenaline

Aplysia californica

-

1 mM inhibits Nalpha-gamma-L-glutamylhistamine synthesis by 73%

1102

serotonin

Aplysia californica

-

1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 92%

1102

tryptamine

Aplysia californica

-

1 mM completely inhibits synthesis of Nalpha-gamma-L-glutamylhistamine

1102

tyramine

Aplysia californica

-

1 mM inhibits Nalpha-gamma-L-glutamylhistamine synthesis by 94%; 1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 94%

1102

additional information

Aplysia californica

-

neither L-histidine nor Nalpha-gamma-L-glutamylhistamine itself have any inhibitory effect on Nalpha-gamma-L-glutamylhistamine formation. In addition, the dipeptides carnosine, homocarnosine, and anserine also have little effect on histamine utilization. Taurine, putrescine, L-tyrosine and L-tryptophan display no inhibitory activity

1102

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