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6.3.2.17: tetrahydrofolate synthase

This is an abbreviated version!
For detailed information about tetrahydrofolate synthase, go to the full flat file.

Word Map on EC 6.3.2.17

Reaction

ATP
+
tetrahydropteroyl-[gamma-Glu]n
 +
L-glutamate
=
ADP
 +
phosphate
 +
tetrahydropteroyl-[gamma-Glu]n+1

Synonyms

100194131, AtDFB, cFPGS, DHFS/FPGS, dihydrofolate synthase/folylpolyglutamate synthase, eFPGS, Folate polyglutamate synthetase, FolC, folyl-gamma-glutamate synthetase, Folylpoly(.gamma.-glutamate) synthase, Folylpoly-.gamma.-glutamate synthase, Folylpoly-gamma-glutamate synthetase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthetase, folylpolyglutamate synthetase 1, Folylpolyglutamyl synthetase, folypoly-gamma-glutamate synthetase, folypolyformyl glutamate synthase, folypolyglutamate synthase, folypolyglutamate synthetase, Formyltetrahydropteroyldiglutamate synthetase, FPGS, FPGS1, FPGS2, GRMZM2G393334, mFGPS, mFPGS, More, MTHFD1L, N10-Formyltetrahydropteroyldiglutamate synthetase, PfDHFS-FPGS, Synthetase, folylpolyglutamate, Tail length regulator, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydrofolylpolyglutamate synthase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.17 tetrahydrofolate synthase

KI Value

KI Value on EC 6.3.2.17 - tetrahydrofolate synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0023 - 0.0052
(6R)-10-formyl-5,6,7,8-tetrahydropteroylpentaglutamate
0.157
(6R)-5,10-dideaza-5,6,7,8-tetrahydropteroyl-L-glutamate-gamma-L-glutamate
-
-
0.179
(6R)-5,10-dideaza-5,6,7,8-tetrahydropteroyl-L-glutamate-gamma-L-glutamate-gamma-L-glutamate-gamma-L-glutamate
-
-
0.144
(6R)-5,10-dideaza-5,6,7,8-tetrahydropteroyl-L-glutamate-gamma-L-glutamate-gamma-L-glutamate-gamma-L-glutamate-gamma-L-glutamate
-
-
0.417
(6R)-5,10-dideaza-5,6,7,8-tetrahydropteroyl-L-glutamate-gamma-L-glutamate-gamma-L-glutamate-gamma-L-glutamate-gamma-L-glutamate-gamma-L-glutamate
-
-
0.076
(6S)-5,10-dideaza-5,6,7,8-tetrahydrofolate
-
-
0.092
(6S)-5,10-dideaza-5,6,7,8-tetrahydropteroyl-L-glutamate-gamma-L-glutamate
-
-
0.0017 - 0.043
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate
0.0037 - 0.054
(6S)-5,6,7,8-tetrahydropteroylpentaglutamate
0.066 - 0.084
(6S)-5-formyl-5,6,7,8-tetrahydropteroylpentaglutamate
0.02 - 0.055
(6S)-5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate
0.00063
2-[[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]phenyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
-
-
0.000091
2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid
-
-
0.00015
4-amino-4-deoxypteroyl-L-ornithine
-
-
0.0000031 - 0.000056
methotrexate-phosphinate
0.000072
Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine
-
-
0.0000017
Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine
-
-
0.000018
Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine
-
-
0.0000083
Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine
-
-
0.00035
Nalpha-(5,8-dideazapteroyl)-L-ornithine
-
-
0.0035
Nalpha-pteroyl-L-ornithine
-
-