6.3.2.17: tetrahydrofolate synthase

This is an abbreviated version!
For detailed information about tetrahydrofolate synthase, go to the full flat file.

Reaction

Synonyms

100194131, AtDFB, cFPGS, DHFS/FPGS, dihydrofolate synthase/folylpolyglutamate synthase, eFPGS, Folate polyglutamate synthetase, FolC, folyl-gamma-glutamate synthetase, Folylpoly(.gamma.-glutamate) synthase, Folylpoly-.gamma.-glutamate synthase, Folylpoly-gamma-glutamate synthetase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthetase, folylpolyglutamate synthetase 1, Folylpolyglutamyl synthetase, folypoly-gamma-glutamate synthetase, folypolyformyl glutamate synthase, folypolyglutamate synthase, folypolyglutamate synthetase, Formyltetrahydropteroyldiglutamate synthetase, FPGS, FPGS1, FPGS2, GRMZM2G393334, mFGPS, mFPGS, More, MTHFD1L, N10-Formyltetrahydropteroyldiglutamate synthetase, PfDHFS-FPGS, Synthetase, folylpolyglutamate, Tail length regulator, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydrofolylpolyglutamate synthase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.17 tetrahydrofolate synthase

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Results	in table
16	Activating Compound
7813	AA Sequence
10	Application
1	CAS Registry Number
46	Cloned(Commentary)
18	Cofactor
6	Crystallization (Commentary)
507	Disease/ Diagnostics
6	Expression
48	General Information
10	General Stability
28	IC50 Value
122	Inhibitors
33	Ki Value [mM]
286	KM Value [mM]
56	Localization
119	Metals/Ions
34	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
155	Organism
5	Pathway
13	PDB ID
30	pH Optimum
5	pH Range
1	Posttranslational Modification
83	Protein Variants
35	Purification (Commentary)
12	Reaction
2	Reaction Type
152	Reference
136	Source Tissue
64	Specific Activity [micromol/min/mg]
17	Storage Stability
481	Substrates and Products (Substrate)
26	Subunits
114	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
35	Turnover Number [1/s]

General Stability

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General Stability on EC 6.3.2.17 - tetrahydrofolate synthase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

2-mercaptoethanol enhances stabilization provided by ATP. ATP stabilizes against heat inactivation

Homo sapiens

-

1057

50% glycerol stabilizes for several days at 4°C

Pisum sativum

-

1090, 1094

K+ and phosphate stabilize

2 entries

MgATP2-, ATP or sulfhydryl compounds increase the lability of the enzyme

Corynebacterium sp.

-

1075

PMSF, benzamidine, and 20% v/v glycerol stabilize

Neurospora crassa

-

1082

stability decreases markedly with further purification

Pisum sativum

-

1094

stabilized by glycerol or by ATP

Mus musculus

-

1081

the enzyme precipitates after a week at concentrations as low as 0.1 mg/ml

Homo sapiens

-

653725

K+ and phosphate stabilize

Corynebacterium sp.

-

1005

K+ and phosphate stabilize

Lacticaseibacillus casei

-

1005