6.3.2.17: tetrahydrofolate synthase

This is an abbreviated version!
For detailed information about tetrahydrofolate synthase, go to the full flat file.

Reaction

Synonyms

100194131, AtDFB, cFPGS, DHFS/FPGS, dihydrofolate synthase/folylpolyglutamate synthase, eFPGS, Folate polyglutamate synthetase, FolC, folyl-gamma-glutamate synthetase, Folylpoly(.gamma.-glutamate) synthase, Folylpoly-.gamma.-glutamate synthase, Folylpoly-gamma-glutamate synthetase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthetase, folylpolyglutamate synthetase 1, Folylpolyglutamyl synthetase, folypoly-gamma-glutamate synthetase, folypolyformyl glutamate synthase, folypolyglutamate synthase, folypolyglutamate synthetase, Formyltetrahydropteroyldiglutamate synthetase, FPGS, FPGS1, FPGS2, GRMZM2G393334, mFGPS, mFPGS, More, MTHFD1L, N10-Formyltetrahydropteroyldiglutamate synthetase, PfDHFS-FPGS, Synthetase, folylpolyglutamate, Tail length regulator, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydrofolylpolyglutamate synthase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.17 tetrahydrofolate synthase

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Results	in table
16	Activating Compound
7813	AA Sequence
10	Application
1	CAS Registry Number
46	Cloned(Commentary)
18	Cofactor
6	Crystallization (Commentary)
507	Disease/ Diagnostics
6	Expression
48	General Information
10	General Stability
28	IC50 Value
122	Inhibitors
33	Ki Value [mM]
286	KM Value [mM]
56	Localization
119	Metals/Ions
34	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
155	Organism
5	Pathway
13	PDB ID
30	pH Optimum
5	pH Range
1	Posttranslational Modification
83	Protein Variants
35	Purification (Commentary)
12	Reaction
2	Reaction Type
152	Reference
136	Source Tissue
64	Specific Activity [micromol/min/mg]
17	Storage Stability
481	Substrates and Products (Substrate)
26	Subunits
114	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
35	Turnover Number [1/s]

Expression

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Expression on EC 6.3.2.17 - tetrahydrofolate synthase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

2- to 5fold increased mRNA expression after treatment with sodium butyrate or suberoylanilide hydroxamic acid

Homo sapiens

-

705451

both TEL-AML1 and E2A-PBX1 down-regulate FPGS gene transcription through association with this multiprotein complex, and this complex also influences FPGS expression throughout lymphoblast cell cycle progression

Homo sapiens

-

716078

correlation between expression and decrease in cell sensitivity

Homo sapiens

-

703000

expressed as single bifunctional protein with dihydrofolate synthase, EC 6.3.2.12

Plasmodium falciparum

-

705610

mechanisms of FPGS downregulation, overview

Homo sapiens

Q05932, Q96LE3

744775

mechanisms of FPGSd ownregulation, overview

Homo sapiens

Q05932, Q96LE3

744775