6.3.2.13: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase
This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase, go to the full flat file.
Word Map on EC 6.3.2.13
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6.3.2.13
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ligases
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d-glutamic
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methicillin
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pgsbca
- 6.3.2.13
- ligases
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d-glutamic
- methicillin
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pgsbca
Reaction
Synonyms
amide ligase, Diaminopimelic-adding enzyme, mDAP ligase, Meso-diaminopimelate-adding enzyme, Mur ligase, MurE, MurE synthetase, MurEEr, peptidoglycan MurE ligase, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyl-meso-2,6-diaminopimelate, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase, UDP-N-acetylmuramyl tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase, UDPMurNAc-L-alanyl-D-glutamate:mDAP ligase (ADP-forming), Uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, Uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate synthetase
ECTree
6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligaseAdvanced search results
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results (General Information
General Information on EC 6.3.2.13 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
the DNPR motif that is characteristic of meso-diaminopimelate-adding enzymes is replaced by HDNR
physiological function
additional information
physiological function
ATP-dependent Mur ligases play essential roles in the biosynthesis of cell wall peptidoglycan as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis
physiological function
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ATP-dependent Mur ligases play essential roles in the biosynthesis of cell wall peptidoglycan as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis
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additional information
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MurE substrate binding sitestructures and three-dimensional structure modeling by homology modeling method, structure comparisons of Mur ligases, detailed overview. Identification of residues playing an important role in the catalytic activity of each of the Mur enzymes, docking of enzyme and substrate and ATP
additional information
MurE substrate binding sitestructures and three-dimensional structure modeling by homology modeling method, structure comparisons of Mur ligases, detailed overview. Identification of residues playing an important role in the catalytic activity of each of the Mur enzymes, docking of enzyme and substrate and ATP
additional information
protein-protein interaction network of MurC, D, E, and F synthetases, overview
additional information
the HDNR motif plays a role in the interaction of the enzyme with L-alanine and meso-diaminopimelic acid. ENzyme structure homology modeling
additional information
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the HDNR motif plays a role in the interaction of the enzyme with L-alanine and meso-diaminopimelic acid. ENzyme structure homology modeling
additional information
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protein-protein interaction network of MurC, D, E, and F synthetases, overview
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