6.3.2.12: dihydrofolate synthase

This is an abbreviated version!
For detailed information about dihydrofolate synthase, go to the full flat file.

Word Map on EC 6.3.2.12

6.3.2.12

tetrahydrofolate

polyglutamylated

analysis

medicine

drug development

biotechnology

Reaction

Synonyms

7,8-Dihydrofolate synthetase, 7,8-Dihydropteroate:L-glutamate ligase (ADP), DHFR, DHFS, dihydrofolate reductase, dihydrofolate synthase, Dihydrofolate synthetase, dihydrofolate synthetase-folylpolyglutamate synthetase, dihydropteroate:L-glutamate ligase (ADP-forming), FHFS, FHFS/FPGS, FolC, Folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, H2-folate synthetase, LH57_13380, PfDHFS-FPGS, PNEJI1_000945, Rv2447c, Synthetase, dihydrofolate

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.12 dihydrofolate synthase

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Results	in table
15632	AA Sequence
8	Application
1	CAS Registry Number
13	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
1	Expression
11	General Information
2	General Stability
1	IC50 Value
35	Inhibitors
3	Ki Value [mM]
26	KM Value [mM]
9	Localization
38	Metals/Ions
8	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
402	Organism
6	Pathway
5	PDB ID
6	pH Optimum
3	pH Range
60	Protein Variants
12	Purification (Commentary)
1	Reaction
2	Reaction Type
51	Reference
4	Source Tissue
7	Specific Activity [micromol/min/mg]
4	Storage Stability
57	Substrates and Products (Substrate)
4	Subunits
43	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 6.3.2.12 - dihydrofolate synthase

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ATP + 7,8-dihydropteroate + L-Glu

Pisum sativum

enzyme of 5,6,7,8-tetrahydropteroyl-Glun synthesis pathway

1026

ATP + 7,8-dihydropteroate + L-Glu

ADP + phosphate + 7,8-dihydrofolate

38 entries

ATP + 7,8-dihydropteroate + L-glutamate

ADP + phosphate + 7,8-dihydropteroylglutamate

8 entries

ATP + L-glutamate + 7,8-dihydropteroate

ADP + phosphate + 7,8-dihydropteroylglutamate

Plasmodium falciparum

assay at pH 10, 37°C

705610

dATP + 7,8-dihydropteroate + L-Glu

dADP + phosphate + 7,8-dihydrofolate

Corynebacterium sp.

40.5% of the activity relative to ATP

1008

GTP + 7,8-dihydropteroate + L-Glu

GDP + phosphate + 7,8-dihydrofolate

3 entries

ITP + 7,8-dihydropteroate + L-Glu

IDP + phosphate + 7,8-dihydrofolate

3 entries

UTP + 7,8-dihydropteroate + L-Glu

UDP + phosphate + 7,8-dihydrofolate

Corynebacterium sp.

79.8% of the activity relative to ATP

1008

additional information

2 entries