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6.3.2.11: carnosine synthase

This is an abbreviated version!
For detailed information about carnosine synthase, go to the full flat file.

Word Map on EC 6.3.2.11

Reaction

ATP
+
L-histidine
+
beta-Alanine
=
ADP
+
phosphate
+
carnosine

Synonyms

ATPGD1, carnosine synthase, Carnosine synthetase, Carnosine-anserine synthetase, Carnosine-homocarnosine synthetase, CARNS, CAS, CRNS1, HCarn-Carn synthetase, Homocarnosine-carnosine synthetase, Synthetase, carnosine

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.11 carnosine synthase

Reference

Reference on EC 6.3.2.11 - carnosine synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Seely, J.E.; Marshall, F.D.
Inhibition of carnosine synthetase by spermidine
Pept. Antibiot. Biosynth. Funct. (Kleinkauf H. et al. eds. )
347-352
1982
Bos taurus, Gallus gallus, Rattus norvegicus
-
Manually annotated by BRENDA team
Seely, J.E.; Marshall, F.D.
Carnosine-synthetase inhibition by beta-alanine analogues
Life Sci.
30
1763-1768
1982
Gallus gallus, Rattus norvegicus
Manually annotated by BRENDA team
Wood, M.R.G.; Johnson, P.
Purification of carnosine synthetase from avian muscle by affinity chromatography and determination of its subunit structure
Biochim. Biophys. Acta
662
138-144
1981
Gallus gallus
Manually annotated by BRENDA team
Kish, S.J.; Perry, T.L.; Hansen, S.
Regional distribution of homocarnosine, homocarnosine-carnosine synthetase and homocarnosinase in human brain
J. Neurochem.
32
1629-1636
1979
Homo sapiens
Manually annotated by BRENDA team
Horinishi, H.; Grillo, M.; Margolis, F.L.
Purification and characterization of carnosine synthetase from mouse olfactory bulbs
J. Neurochem.
31
909-919
1978
Mus musculus
Manually annotated by BRENDA team
Ng, R.H.; Marshall, F.D.
Regional and subcellular distribution of homocarnosine-carnosine synthetase in the central nervous system of rats
J. Neurochem.
30
187-190
1978
Rattus norvegicus
-
Manually annotated by BRENDA team
Ng, R.H.; Marshall, F.D.
Subcellular distribution and some properties of homocarnosine-carnosine synthetase from chick red blood cells
Comp. Biochem. Physiol. B
54
523-525
1976
Gallus gallus
Manually annotated by BRENDA team
Ng, R.H.; Marshall, F.D.
Distribution of homocarnosine-carnosine synthetase in tissues of rat, mouse, chick and frog
Comp. Biochem. Physiol. B
54
519-521
1976
Gallus gallus, Mus musculus, Lithobates pipiens, Rattus norvegicus
Manually annotated by BRENDA team
Ng, R.H.; Marshall, F.D.
The effect of various agents in vitro on homocarnosine-carnosine synthetase from rat brain
Experientia
32
839-841
1976
Rattus norvegicus
Manually annotated by BRENDA team
Skaper, S.D.; Das, S.; Marshall, F.D.
Some properties of a homocarnosine-carnosine synthetase isolated from rat brain
J. Neurochem.
21
1429-1445
1973
Rattus norvegicus
Manually annotated by BRENDA team
Kalyankar, G.D.; Meister, A.
Carnosine synthetase (chick muscle)
Methods Enzymol.
17
102-105
1971
Gallus gallus
-
Manually annotated by BRENDA team
McManus, R.; Benson, M.S.
Studies on the formation of carnosine and anserine in pectoral muscle of the developing chick
Arch. Biochem. Biophys.
119
444-453
1967
Gallus gallus
Manually annotated by BRENDA team
Stenesh, J.J.; Winnick, T.
Carnosine-anserine synthetase of muscle. 4. Partial purification of the enzyme and further studies of beta-alanyl peptide synthesis
Biochem. J.
77
575-581
1960
Gallus gallus
Manually annotated by BRENDA team
Kalyankar, G.D.; Meister, A.
Enzymatic synthesis of carnosine and related beta-alanyl and gamma-aminobutyryl peptides
J. Biol. Chem.
234
3210-3218
1959
Gallus gallus
Manually annotated by BRENDA team
Crowe, M.J.; Pixley, S.K.
Monoclonal antibody to carnosine synthetase identifies a subpopulation of frog olfactory receptor neurons
Brain Res.
538
147-151
1991
Lithobates pipiens
Manually annotated by BRENDA team
Bulygina, E.R.; Kramarenko, G.G.
Isolation of carnosine synthetase from animal and human muscles
Vopr. Med. Khim.
41
27-30
1995
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Harding, J.W.; O¦Fallon, J.V.
The subcellular distribution of carnosine, carnosine synthetase, and carnosinase in mouse olfactory tissues
Brain Res.
173
99-109
1979
Mus musculus
Manually annotated by BRENDA team
Nagai, K.; Niijima, A.; Yamano, T.; Otani, H.; Okumra, N.; Tsuruoka, N.; Nakai, M.; Kiso, Y.
Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves
Exp. Biol. Med.
228
1138-1145
2003
Rattus norvegicus
Manually annotated by BRENDA team
Drozak, J.; Veiga-da-Cunha, M.; Vertommen, D.; Stroobant, V.; Van Schaftingen, E.
Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)
J. Biol. Chem.
285
9346-9356
2010
Gallus gallus (D3KCC4), Gallus gallus, Homo sapiens (A5YM72), Homo sapiens, Mus musculus (Q6ZPS2), Mus musculus
Manually annotated by BRENDA team
Sale, C.; Saunders, B.; Harris, R.
Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance
Amino Acids
39
321-333
2010
Homo sapiens
Manually annotated by BRENDA team
Peters, V.; Klessens, C.Q.; Baelde, H.J.; Singler, B.; Veraar, K.A.; Zutinic, A.; Drozak, J.; Zschocke, J.; Schmitt, C.P.; de Heer, E.
Intrinsic carnosine metabolism in the human kidney
Amino Acids
47
2541-2550
2015
Homo sapiens (A5YM72), Homo sapiens
Manually annotated by BRENDA team