6.3.2.11: carnosine synthase

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For detailed information about carnosine synthase, go to the full flat file.

Reaction

Synonyms

ATPGD1, carnosine synthase, Carnosine synthetase, Carnosine-anserine synthetase, Carnosine-homocarnosine synthetase, CARNS, CAS, CRNS1, HCarn-Carn synthetase, Homocarnosine-carnosine synthetase, Synthetase, carnosine

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.11 carnosine synthase

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2	Activating Compound
20	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
5	Cofactor
32	Disease/ Diagnostics
1	General Information
3	General Stability
47	Inhibitors
21	kcat/KM [mM/s]
31	KM Value [mM]
4	Localization
10	Metals/Ions
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
30	Organism
6	Pathway
5	pH Optimum
1	pH Range
1	pH Stability
10	Purification (Commentary)
3	Reaction
3	Reaction Type
30	Reference
65	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
85	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.2.11 - carnosine synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + L-His + beta-Ala

ADP + phosphate + carnosine

Homo sapiens

-

the concentration of histidine in muscle and plasma is high relative to its Km with muscle carnosine synthase, whereas beta-alanine exists in low concentration in muscle and has a higher Km with muscle carnosine synthase, which indicates that it is the availability of beta-alanine that is limiting to the synthesis of carnosine in skeletal muscle

713729

-

-

?

ATP + L-histidine + beta-alanine

ADP + phosphate + carnosine

Homo sapiens

A5YM72

-

744004

-

-

?

L-histidine + beta-alanine + ATP

carnosine + AMP + diphosphate

Rattus norvegicus

-

-

651204

-

651204

?