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6.3.2.11: carnosine synthase

This is an abbreviated version!
For detailed information about carnosine synthase, go to the full flat file.

Word Map on EC 6.3.2.11

Reaction

ATP
+
L-histidine
+
beta-Alanine
=
ADP
+
phosphate
+
carnosine

Synonyms

ATPGD1, carnosine synthase, Carnosine synthetase, Carnosine-anserine synthetase, Carnosine-homocarnosine synthetase, CARNS, CAS, CRNS1, HCarn-Carn synthetase, Homocarnosine-carnosine synthetase, Synthetase, carnosine

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.11 carnosine synthase

Inhibitors

Inhibitors on EC 6.3.2.11 - carnosine synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-Diaminodecane
-
10 mM, 43% loss of activity
1,8-diaminooctane
-
10 mM, 27% loss of activity
1-methylhistidine
-
synthesis of carnosine
2-Aminoethylphosphonic acid
3-Aminopropane sulfonic acid
3-Aminopropanephosphonic acid
-
-
3-methylhistidine
-
synthesis of carnosine
5-Aminopentanoate
5-Aminopentanol
-
10 mM, 11% loss of activity
6-Aminohexanol
-
10 mM, 10% loss of activity
alpha-Methyl-dopa
-
-
Aminoethanol
-
10 mM, 17% loss of activity
Aminooxyacetate
-
-
chlorpromazine
-
0.1 mM stimulates, 1 mM inhibits 45%
diphosphate
-
-
dithiothreitol
-
-
Fe2+
-
weak
iodoacetamide
K+
-
10-100 mM, weak inhibition
Mo2+
-
weak
n-butylamine
-
10 mM, 15% loss of activity
n-Hexylamine
-
10 mM, 34% loss of activity
n-octylamine
-
10 mM, 58% loss of activity
Nipecotic acid
-
-
norepinephrine
-
-
O-Phosphoethanolamine
phosphate
-
-
spermidine