6.3.1.9: trypanothione synthase

This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.

Word Map on EC 6.3.1.9

6.3.1.9

trypanosoma

leishmania

trypanosomatids

brucei

cruzi

fasciculata

crithidia

n1,n8-bisglutathionylspermidine

chagas

infantum

tryparedoxine

antileishmanial

parasite-specific

kinetoplastida

antitrypanosomal

drug development

synthesis

pharmacology

Reaction

Synonyms

Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.9 trypanothione synthase

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Results	in table
15	Activating Compound
47	AA Sequence
8	Application
2	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
2	Crystallization (Commentary)
3	Expression
29	General Information
1	General Stability
104	IC50 Value
174	Inhibitors
16	Ki Value [mM]
41	KM Value [mM]
5	Localization
18	Metals/Ions
9	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
37	Organism
6	Pathway
5	PDB ID
13	pH Optimum
3	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
1	Reaction Type
36	Reference
18	Source Tissue
5	Specific Activity [micromol/min/mg]
83	Substrates and Products (Substrate)
11	Subunits
68	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
13	Turnover Number [1/s]

KI Value

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KI Value on EC 6.3.1.9 - trypanothione synthase

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0.0063

betulin

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114

0.0031

conessine

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114

0.132 - 1.085

glutathione

6 entries

0.0068 - 0.0125

tomatine

2 entries

0.223 - 0.377

trypanothione

4 entries

0.0036

uvaol

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114

additional information

2 entries