6.3.1.9: trypanothione synthase

This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.

Word Map on EC 6.3.1.9

6.3.1.9

trypanosoma

leishmania

trypanosomatids

brucei

cruzi

fasciculata

crithidia

n1,n8-bisglutathionylspermidine

chagas

infantum

tryparedoxine

antileishmanial

parasite-specific

kinetoplastida

antitrypanosomal

drug development

synthesis

pharmacology

Reaction

Synonyms

Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.9 trypanothione synthase

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Results	in table
15	Activating Compound
47	AA Sequence
8	Application
2	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
2	Crystallization (Commentary)
3	Expression
29	General Information
1	General Stability
104	IC50 Value
174	Inhibitors
16	Ki Value [mM]
41	KM Value [mM]
5	Localization
18	Metals/Ions
9	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
37	Organism
6	Pathway
5	PDB ID
13	pH Optimum
3	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
1	Reaction Type
36	Reference
18	Source Tissue
5	Specific Activity [micromol/min/mg]
83	Substrates and Products (Substrate)
11	Subunits
68	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
13	Turnover Number [1/s]

IC50 Value

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of the Enzyme Summary Page.

IC50 Value on EC 6.3.1.9 - trypanothione synthase

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0.0026

1,3,5-trimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-1H-pyrazole-4-sulfonamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.1

1-(3-(1-isobutyl-1H-pyrazol-4-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0037

1-(3-(1H-indol-4-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.00035

1-(3-(3-chlorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00009

1-(3-(3-fluorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.003

1-(3-(3-pyridyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

1-(3-(4-chlorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0019

1-(3-(furan-2-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00015

1-(3-phenyl-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0003

1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0027

1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)butan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0065

1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)propan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0019

1-(5-(3,5-difluorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0015

1-(5-(3-fluorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00012

1-(tert-butylsulfonylmethyl)-3-(3-fluorophenyl)-1H-indazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.000095

1-[3-(3-fluorophenyl)-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH 8.0, 22°C

704603

0.0072

1-[5-(3-chloro-4-methylphenyl)-2H-tetrazol-2-yl]-3,3-dimethylbutan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0022

2,4-dimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-1,3-thiazole-5-sulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.024

2,4-dimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]thiophene-3-sulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0063

2,6-dichloro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.016

2,6-dichloro-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0061

2,6-difluoro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

2,6-dimethoxy-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0011

2-((tert-butylsulfonyl)methyl)-4-(2-fluorophenyl)thiazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0032

2-((tert-butylsulfonyl)methyl)-4-(2-methylphenyl)thiazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0004

2-((tert-butylsulfonyl)methyl)-4-(3-chlorophenyl)thiazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.012

2-((tert-butylsulfonyl)methyl)-4-(3-methoxyphenyl)thiazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0012

2-((tert-butylsulfonyl)methyl)-4-(phenyl)thiazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00014

2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-1-(piperidin-1-yl)ethanone

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00011

2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N,N-dimethylacetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00086

2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(2-(4-methylpiperazin-1-yl)ethyl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00083

2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0006

2-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)-N,N-dimethylacetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.045

2-(5-(3,5-difluorophenyl)-2H-tetrazol-2-yl)-1-phenylethanone

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00015

2-(9-bromo-3-chloro-6-oxo-7,12-dihydroindolo[3,2-d][1]benzazepin-5(6H)-yl)-N-[2-(methylamino)ethyl]acetamide

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0011

2-(tert-butylsulfonylmethyl)-4-(3-trifluoromethylphenyl)thiazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.037

2-methyl-N-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)propane-2-sulfonamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.00014

2-[3-(3-fluorophenyl)-1H-indazol-1-yl]-1-(piperidin-1-yl)ethanone

Trypanosoma brucei

pH 8.0, 22°C

704603

0.1

3,3-dimethyl-1-(3-(1-methyl-1H-indol-4-yl)-1H-indazol-1-yl)butan-2-one

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.1

3,3-dimethyl-1-(3-(naphthalen-2-yl)-1H-indazol-1-yl)butan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0003

3,3-dimethyl-1-(3-(pyridin-4-yl)-1H-indazol-1-yl)butan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0004

3,3-dimethyl-1-(3-(thiophen-3-yl)-1H-indazol-1-yl)butan-2-one

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0088

3,3-dimethyl-1-(5-phenyl-2H-tetrazol-2-yl)butan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0035

3,3-dimethyl-1-[5-[3-(trifluoromethyl)phenyl]-2H-tetrazol-2-yl]butan-2-one

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

3,3-dimethyl-1-[5-[4-(trifluoromethyl)phenyl]-2H-tetrazol-2-yl]butan-2-one

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0058

3,5-dichloro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

3-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-5-methylisoxazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

3-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-5-phenylisoxazole

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0029

3-(3-fluorophenyl)-1-(pyridin-2-ylmethyl)-1H-indazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0045

3-(3-fluorophenyl)-1-(pyridin-3-ylmethyl)-1H-indazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00008

3-(tert-butylsulfonylmethyl)-1-(3-fluorophenyl)-1H-indazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00022

3-(tert-butylsulfonylmethyl)-1-phenyl-1H-indazole

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.028

4-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-2,5-dimethyloxazole

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0087

4-acetyl-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.011

4-methoxy-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.004

4-methoxy-N-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

4-methyl-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0313

5-oxo-1H,3H-5lambda5-benzo[1,2-c:4,5-c']bis[1,2,5]oxadiazole

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0117

betulin

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114

0.0134

conessine

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114

0.02

methyl (3-phenyl-1H-indazol-1-yl)acetate

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0138

N,N'-[6-(2,5-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diyl]bis(N'-tert-butylurea)

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0153

N,N'-[6-(2H-1,3-benzodioxol-5-yl)pyrido[2,3-d]pyrimidine-2,7-diyl]bis(N'-tert-butylurea)

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.1

N,N-dibenzyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0002

N,N-diethyl-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.015

N,N-diethyl-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0056

N-(1-phenylethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.000145

N-(2-(dimethylamino)ethyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.03

N-(2-methoxyethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.005

N-(2-phenylethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00035

N-(3-(1H-imidazol-1-yl)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.000045

N-(3-(dimethylamino)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

N-(4-chlorobenzyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.003

N-(4-chlorobenzyl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1Hindazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.05

N-(4-[methyl[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfamoyl]phenyl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0059

N-(4-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfamoyl]phenyl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.012

N-(butan-2-yl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0039

N-(thiophen-2-ylmethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

N-cyclohexyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.00017

N-methyl-(3-(dimethylamino)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

N-phenyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.013

N-propyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.002 - 4

N-[(2-phenyl-1,3-thiazol-4-yl)methyl]naphthalene-2-sulfonamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.05

N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.1

N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]naphthalene-1-sulfonamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0085

N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]thiophene-2-sulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.00035

N-[2-(methylamino)ethyl]-2-[6-oxo-9-(trifluoromethyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-5(6H)-yl]acetamide

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0136

N-[2-amino-6-(2H-1,3-benzodioxol-5-yl)pyrido[2,3-d]pyrimidin-7-yl]-N'-ethylthiourea

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0321

N-[2-amino-6-(naphthalen-2-yl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0037

N-[4-([[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]sulfamoyl)phenyl]acetamide

Trypanosoma brucei

above, pH and temperature not specified in the publication

727329

0.0017

N-[4-([[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]sulfamoyl)phenyl]acetamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.025

N-[[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.015

N-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.0478

N1,N10-bis[[4-(propan-2-yl)phenyl]methyl]decane-1,10-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0259

N1,N12-bis[(4-bromophenyl)methyl]dodecane-1,12-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0515

N1,N12-bis[(4-chlorophenyl)methyl]dodecane-1,12-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0234

N1,N4-bis[[4-(benzyloxy)-3-methoxyphenyl]methyl]butane-1,4-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0567

N1,N4-bis[[4-(benzyloxy)phenyl]methyl]butane-1,4-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0263

N1,N6-bis[[4-(benzyloxy)-3-methoxyphenyl]methyl]hexane-1,6-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0391

N1,N6-bis[[4-(benzyloxy)phenyl]methyl]hexane-1,6-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0496

N1,N8-bis[[4-(benzyloxy)-3-methoxyphenyl]methyl]octane-1,8-diamine

Leishmania infantum

A4I2Z3

pH 7.4, 22°C, recombinant enzyme

746173

0.0029

tert-butyl-4-(2-(2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamido)ethyl)piperazine-1-carboxylate

Trypanosoma brucei

pH and temperature not specified in the publication

727329

0.018

tomatine

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114

0.0112

uvaol

Leishmania donovani

G5D5D5

pH 8.0, 25°C, recombinant enzyme

727114