6.3.1.9: trypanothione synthase
This is an abbreviated version!
For detailed information about trypanothione synthase, go to the full flat file.
Word Map on EC 6.3.1.9
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6.3.1.9
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trypanosoma
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leishmania
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trypanosomatids
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brucei
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cruzi
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fasciculata
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crithidia
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n1,n8-bisglutathionylspermidine
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chagas
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infantum
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tryparedoxine
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antileishmanial
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parasite-specific
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kinetoplastida
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antitrypanosomal
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drug development
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synthesis
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pharmacology
- 6.3.1.9
- trypanosoma
- leishmania
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trypanosomatids
- brucei
- cruzi
- fasciculata
- crithidia
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n1,n8-bisglutathionylspermidine
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chagas
- infantum
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tryparedoxine
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antileishmanial
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parasite-specific
- kinetoplastida
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antitrypanosomal
- drug development
- synthesis
- pharmacology
Reaction
Synonyms
Cf-TS, GenBank AF006615-derived protein GI 3004644, LdTryS, LiTRYS, Synthetase, trypanothione, Synthetase, trypanothione (Crithidia fasciculata strain HS6 gene Cf-TS), T(SH)2 synthetase, TbTryS, TcTryS, TRS, trypanothione synthase, Trypanothione synthetase, Trypanothione synthetase (Crithidia fasciculata strain HS6 gene Cf-TS), trypanothione synthetase-amidase, TryS, TSA, TSH synthetase, tyrS
ECTree
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General Information
General Information on EC 6.3.1.9 - trypanothione synthase
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malfunction
metabolism
physiological function
additional information
genetic knockout mutants of both alleles are not viable, chemical targeting of LiTRYS with a drug-like compound FS-554 also leads to parasite death
malfunction
Leishmania infantum MHOM / MA / 67 / ITMAP263
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genetic knockout mutants of both alleles are not viable, chemical targeting of LiTRYS with a drug-like compound FS-554 also leads to parasite death
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trypanothione synthetase catalyses the two-step biosynthesis of trypanothione from spermidine and glutathione
metabolism
trypanothione dependent redox metabolism, overview. Trypanothione synthetase catalyzes the ligation of two molecules of gluthatione to one of spermidine using the energy provided by two ATP molecules. Trypanothione reductase maintains trypanothione in the reduced state at expenses of NADPH, which can be supplied by the oxidative phase of the pentose phosphate pathway via glucose 6-phosphate dehydrogenase
metabolism
trypanothione dependent redox metabolism, overview. Trypanothione synthetase catalyzes the ligation of two molecules of gluthatione to one of spermidine using the energy provided by two ATP molecules. Trypanothione reductase maintains trypanothione in the reduced state at expenses of NADPH, which can be supplied by the oxidative phase of the pentose phosphate pathway via glucose 6-phosphate dehydrogenase
metabolism
trypanothione dependent redox metabolism, overview. Trypanothione synthetase catalyzes the ligation of two molecules of gluthatione to one of spermidine using the energy provided by two ATP molecules. Trypanothione reductase maintains trypanothione in the reduced state at expenses of NADPH, which can be supplied by the oxidative phase of the pentose phosphate pathway via glucose 6-phosphate dehydrogenase
metabolism
trypanothione synthetase (TryS) of thiol metabolic pathway is the sole enzyme responsible for the biosynthesis of trypanothione in Leishmania donovani
metabolism
Leishmania donovani MHOM / IN / 80 / Dd8
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trypanothione synthetase (TryS) of thiol metabolic pathway is the sole enzyme responsible for the biosynthesis of trypanothione in Leishmania donovani
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metabolism
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trypanothione dependent redox metabolism, overview. Trypanothione synthetase catalyzes the ligation of two molecules of gluthatione to one of spermidine using the energy provided by two ATP molecules. Trypanothione reductase maintains trypanothione in the reduced state at expenses of NADPH, which can be supplied by the oxidative phase of the pentose phosphate pathway via glucose 6-phosphate dehydrogenase
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metabolism
Leishmania donovani MHOM / IN / 83 / Ag
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trypanothione synthetase (TryS) of thiol metabolic pathway is the sole enzyme responsible for the biosynthesis of trypanothione in Leishmania donovani
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metabolism
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trypanothione dependent redox metabolism, overview. Trypanothione synthetase catalyzes the ligation of two molecules of gluthatione to one of spermidine using the energy provided by two ATP molecules. Trypanothione reductase maintains trypanothione in the reduced state at expenses of NADPH, which can be supplied by the oxidative phase of the pentose phosphate pathway via glucose 6-phosphate dehydrogenase
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metabolism
Leishmania infantum JPCM5 /MHOM / MA / 67 / ITMAP263
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trypanothione dependent redox metabolism, overview. Trypanothione synthetase catalyzes the ligation of two molecules of gluthatione to one of spermidine using the energy provided by two ATP molecules. Trypanothione reductase maintains trypanothione in the reduced state at expenses of NADPH, which can be supplied by the oxidative phase of the pentose phosphate pathway via glucose 6-phosphate dehydrogenase
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culture of a tetracyclinedependent conditional double knockout cDKO parasites without tetracycline induction results in loss of trypanothione and accumulation of glutathione, followed by growth inhibition and cell lysis after 6 days. In the absence of inducer, cDKO cells are unable to infect mice, confirming that the enzyme is essential for virulence in vivo as well as in vitro
physiological function
in pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Reduced trypanothione is involved in multiple functions such as the detoxification of xenobiotics, cell proliferation, defense against oxidants and protein thiol-redox homeostasis
physiological function
in pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Reduced trypanothione is involved in multiple functions such as the detoxification of xenobiotics, cell proliferation, defense against oxidants and protein thiol-redox homeostasis
physiological function
in pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Reduced trypanothione is involved in multiple functions such as the detoxification of xenobiotics, cell proliferation, defense against oxidants and protein thiol-redox homeostasis
physiological function
the enzyme is involved in Amp B resistance and during oxidative stress to help the parasites survival
physiological function
trypanothione synthetase, EC 6.3.1.9, but not glutathionylspermidine synthetase, EC 6.3.1.8, is essential for Leishmania infantum
physiological function
Leishmania infantum MHOM / MA / 67 / ITMAP263
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trypanothione synthetase, EC 6.3.1.9, but not glutathionylspermidine synthetase, EC 6.3.1.8, is essential for Leishmania infantum
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physiological function
Leishmania donovani MHOM / IN / 80 / Dd8
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the enzyme is involved in Amp B resistance and during oxidative stress to help the parasites survival
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physiological function
-
in pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Reduced trypanothione is involved in multiple functions such as the detoxification of xenobiotics, cell proliferation, defense against oxidants and protein thiol-redox homeostasis
-
physiological function
Leishmania donovani MHOM / IN / 83 / Ag
-
the enzyme is involved in Amp B resistance and during oxidative stress to help the parasites survival
-
physiological function
-
in pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Reduced trypanothione is involved in multiple functions such as the detoxification of xenobiotics, cell proliferation, defense against oxidants and protein thiol-redox homeostasis
-
physiological function
Leishmania infantum JPCM5 /MHOM / MA / 67 / ITMAP263
-
in pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Reduced trypanothione is involved in multiple functions such as the detoxification of xenobiotics, cell proliferation, defense against oxidants and protein thiol-redox homeostasis
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binding sites for glutathione, ATP and two Mg2+ ions, molecular docking and molecular dynamics simulations, strructure modeling, detailed overview
additional information
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the steady-state kinetic analysis discard a ping-pong mechanism
additional information
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docking study and structure homology modeling using Leishmania major TryS, PDB ID 2VOB, structure as template, overview
additional information
Trypanosoma cruzi DTU I
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docking study and structure homology modeling using Leishmania major TryS, PDB ID 2VOB, structure as template, overview
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additional information
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the steady-state kinetic analysis discard a ping-pong mechanism
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