6.3.1.8: glutathionylspermidine synthase

This is an abbreviated version!
For detailed information about glutathionylspermidine synthase, go to the full flat file.

Word Map on EC 6.3.1.8

6.3.1.8

trypanothione

trypanosomatids

gsh

trypanosoma

leishmania

n1,n8-bisglutathionylspermidine

cruzi

polyamine

brucei

gamma-glu-cys-gly

ligases

protozoa

tetrahedral

mgatp

obeys

slow-binding

kinetoplastida

anti-parasitic

phosphinate

atp-grasp

acyl-enzyme

polyamine-containing

bollinger

histidine-dependent

glutathione-like

aminopropylates

mg2+-atp

glutathionylation

drug development

pharmacology

Reaction

Synonyms

bifunctional glutathionylspermidine synthetase/amidase, Gen Bank AE000381-derived protein GI 1789361, GenBank U66520-derived protein GI 1813514, Glutathione:spermidine ligase (ADP-forming), Glutathione:spermidine ligase [ADP-forming], glutathionylspermidine synthetase, Glutathionylspermidine synthetase (Crithidia fasciculata strain HS6 gene Cf-GSS), Glutathionylspermidine synthetase (Crithidia fasciculata), Glutathionylspermidine synthetase/amidase, Gsp synthetase, GspS, GspSA, LiGSPS, Protein (Escherichia coli strain K12-MG1655 gene gsp), Synthetase, glutathionylspermidine, Synthetase, glutathionylspermidine (Crithidia fasciculata fragment), Synthetase, glutathionylspermidine (Crithidia fasciculata strain HS6 gene Cf-GSS), Synthetase, glutathionylspermidine (Crithidia fasciculata), Synthetase, glutathionylspermidine (Escherichia coli clone pJBM1 gene gsp), TryS

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.8 glutathionylspermidine synthase

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Results	in table
578	AA Sequence
4	Application
5	CAS Registry Number
12	Cloned(Commentary)
7	Cofactor
2	Crystallization (Commentary)
4	General Information
1	IC50 Value
37	Inhibitors
8	Ki Value [mM]
41	KM Value [mM]
1	Localization
7	Metals/Ions
9	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
25	Organism
5	Pathway
15	PDB ID
5	pH Optimum
1	pH Range
1	pI Value
15	Protein Variants
10	Purification (Commentary)
5	Reaction
1	Reaction Type
23	Reference
1	Renatured (Commentary)
2	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
41	Substrates and Products (Substrate)
5	Subunits
31	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

KM Value

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KM Value on EC 6.3.1.8 - glutathionylspermidine synthase

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0.052 - 0.215

ATP

2 entries

gamma-Glu-L-Cys(S-butyl)-Gly

Crithidia fasciculata

966

0.18

gamma-Glu-L-Cys(S-ethyl)-Gly

Crithidia fasciculata

966

0.53

gamma-Glu-L-Cys(S-propyl)-Gly

Crithidia fasciculata

966

gamma-L-Glu-L-Ala-Gly

Crithidia fasciculata

966

0.13

gamma-L-Glu-L-Cys(S-methyl)-Gly

Crithidia fasciculata

966

0.91

gamma-L-Glu-L-Cys-Gly

Crithidia fasciculata

966

0.4

gamma-L-Glu-L-Ile-Gly

Crithidia fasciculata

966

0.67

gamma-L-Glu-L-Val-Gly

Crithidia fasciculata

966

0.0224 - 7.298

glutathione

14 entries

0.5

glutathionylspermidine

Crithidia fasciculata

P90518

pH 7.3, 25°C, amidase activity

649733

0.096 - 0.114

MgADP-

2 entries

0.059 - 7.424

spermidine

14 entries