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6.3.1.8: glutathionylspermidine synthase

This is an abbreviated version!
For detailed information about glutathionylspermidine synthase, go to the full flat file.

Word Map on EC 6.3.1.8

Reaction

glutathione
+
spermidine
 +
ATP
=
glutathionylspermidine
 +
ADP
 +
phosphate

Synonyms

bifunctional glutathionylspermidine synthetase/amidase, Gen Bank AE000381-derived protein GI 1789361, GenBank U66520-derived protein GI 1813514, Glutathione:spermidine ligase (ADP-forming), Glutathione:spermidine ligase [ADP-forming], glutathionylspermidine synthetase, Glutathionylspermidine synthetase (Crithidia fasciculata strain HS6 gene Cf-GSS), Glutathionylspermidine synthetase (Crithidia fasciculata), Glutathionylspermidine synthetase/amidase, Gsp synthetase, GspS, GspSA, LiGSPS, Protein (Escherichia coli strain K12-MG1655 gene gsp), Synthetase, glutathionylspermidine, Synthetase, glutathionylspermidine (Crithidia fasciculata fragment), Synthetase, glutathionylspermidine (Crithidia fasciculata strain HS6 gene Cf-GSS), Synthetase, glutathionylspermidine (Crithidia fasciculata), Synthetase, glutathionylspermidine (Escherichia coli clone pJBM1 gene gsp), TryS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.8 glutathionylspermidine synthase

Inhibitors

Inhibitors on EC 6.3.1.8 - glutathionylspermidine synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-[[([2-[(4-amino-4-carboxybutanoyl)amino]propanoyl]amino)methyl](hydroxy)phosphoryl]ethyl)(hydroxy)dioxophosphate(1-)
inhibits the reaction in the presence of spermidine
4-[(14-ammonio-5-hydroxy-1-methyl-5-oxido-2-oxo-6-oxa-3,10-diaza-5-phosphatetradec-1-yl)amino]-1-carboxy-4-oxobutan-1-aminium
-
4-[[2-([[[4-[(4-ammoniobutyl)amino]butyl](hydroxy)phosphoryl]methyl]amino)-1-methyl-2-oxoethyl]amino]-1-carboxy-4-oxobutan-1-aminium
-
buthionine sulfoximine
-
-
gamma-Aminobutyryl-L-Ala-Gly
-
5 mM, 10% inhibition
gamma-glutamyl-N-[[(3-aminopropoxy)(2-phosphonoethyl)phosphoryl]methyl]alaninamide
-
gamma-L-Glu-D-Phe-Gly
-
5 mM, 10% inhibition
gamma-L-Glu-L-Leu
-
5 mM, 10% inhibition
gamma-L-Glu-L-Leu-Gly
-
5 mM, 58% inhibition
gamma-L-Glu-L-leu-L-Ala
-
5 mM, 95% inhibition
gamma-L-Glu-L-Phe-Gly
-
5 mM, 73% inhibition
gamma-L-Glu-L-Ser-Gly
-
5 mM, 50% inhibition
gamma-L-Glu-L-Val
-
5 mM, 10% inhibition
gamma-L-Glu-L-Val-L-Ala
-
5 mM, 58% inhibition
gamma-L-glutamyl-L-cysteinyl-diaminopropionic acid
-
-
Glutaryl-L-Val-Gly
-
5 mM, 10% inhibition
Hydrogen O-[3-[N-(4-Aminobutyl)amino]propyl][[(gamma-glutamylalanyl)amino]methyl]phosphonate
-
-
L-beta-Asp-L-Leu-Gly
-
5 mM, 42% inhibition
L-beta-Asp-L-Val-Gly
-
5 mM, 15% inhibition
L-Cys-Gly
-
5 mM, 20% inhibition
Melarsen oxide
-
-
N1-glutathionylspermidine analogs
-
selective inhibitors against EC 6.3.1.8 and EC 3.5.1.78 activities provide evidence of interdomain communication in the bifunctional enzyme
nifurtimox
-
-
Non-polyamine-containing phosphoamidate
-
-
-
Pentamidine
-
-
Phosphinate
behaves as a slow-binding bisubstrate inhibitor, competitive with respect to GSH and spermidine
phosphinate analogue of glutathionylspermidine
slow tight-binding inhibition
phosphonate
acts as a a simple ground state analogue of glutathione
phosphonate analogue of glutathionylspermidine
classical, linear competitive inhibition with respect to GSH
Polyamine-containing phosphapeptides
-
potent and selective
-
reduced trypanothione
-
-
triostam
-
-
additional information
-