6.3.1.5: NAD+ synthase

This is an abbreviated version!
For detailed information about NAD+ synthase, go to the full flat file.

Word Map on EC 6.3.1.5

6.3.1.5

adenylyltransferase

nmnat

glutamine-dependent

nucleolus-associated

analysis

pharmacology

drug development

Reaction

Synonyms

ammonia-dependent NADS, ammonia-dependent nicotinamide adenine dinucleotide synthetase, ammonia-specific NAD synthase, ammonia-specific NAD synthetase, Diphosphopyridine nucleotide synthetase, draNADS, MJ1352, mj_NADS, NAD synthase, NAD synthetase, NAD+ synthetase, NadE, NADS, NH3-dependent NAD+ synthetase, Nicotinamide adenine dinucleotide synthetase, Qns1, Synthetase, nicotinamide adenine dinucleotide

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.5 NAD+ synthase

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Results	in table
21298	AA Sequence
10	Application
1	CAS Registry Number
15	Cloned(Commentary)
16	Cofactor
12	Crystallization (Commentary)
11	General Information
12	IC50 Value
26	Inhibitors
3	kcat/KM [mM/s]
22	KM Value [mM]
2	Localization
15	Metals/Ions
6	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
227	Organism
9	Pathway
49	PDB ID
8	pH Optimum
3	pH Range
1	pI Value
16	Protein Variants
16	Purification (Commentary)
4	Reaction
19	Reaction Type
40	Reference
1	Source Tissue
24	Specific Activity [micromol/min/mg]
4	Storage Stability
61	Substrates and Products (Substrate)
11	Subunits
77	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Temperature Stability [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 6.3.1.5 - NAD+ synthase

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2-fluoro-ATP + deamido-NAD+ + NH3

2-fluoro-AMP + diphosphate + NAD+

Staphylococcus aureus

692766

ATP + deamido-NAD+ + Asp

AMP + diphosphate + NAD+ + oxaloacetate

2 entries

ATP + deamido-NAD+ + Glu

AMP + diphosphate + NAD+ + 2-oxoglutarate

2 entries

ATP + deamido-NAD+ + glutamine

AMP + diphosphate + glutamate + NAD+

Escherichia coli

653053

ATP + deamido-NAD+ + glutamine

AMP + diphosphate + NAD+ + glutamate

Mycobacterium tuberculosis

653750

ATP + deamido-NAD+ + L-Gln

AMP + diphosphate + NAD+ + Glu

4 entries

ATP + deamido-NAD+ + NH3

4 entries

ATP + deamido-NAD+ + NH3

AMP + diphosphate + NAD+

33 entries

ATP + deamido-NAD+ + NH4+

AMP + diphosphate + NAD+

Geobacillus stearothermophilus

661506

ATP + deamido-NAD+ + NH4+

AMP + diphosphate + NAD+ + H+

Mycobacterium tuberculosis

653750

ATP + deamido-NMN + NH3

AMP + diphosphate + NMN

Francisella tularensis

A0A0B3VMT3

existence of an alternative route of NAD synthesis where the amidation of NaMN to nicotinamide mononucleotide occurs before the adenylylation reaction, which converts the intermediate to the NAD cofactor. The first step is catalyzed by Francisella tularensis NadE

706533

dATP + deamido-NAD+ + NH3

dAMP + diphosphate + NAD+

2 entries

additional information

3 entries