6.3.1.15: 8-demethylnovobiocic acid synthase

This is an abbreviated version!
For detailed information about 8-demethylnovobiocic acid synthase, go to the full flat file.

Reaction

Synonyms

8-demethylnovobiocic acid synthetase, 8-desmethyl-novobiocic acid synthetase, NovL, novobiocin ligase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.15 8-demethylnovobiocic acid synthase

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Results	in table
24	AA Sequence
1	Cloned(Commentary)
4	General Information
1	Inhibitors
2	kcat/KM [mM/s]
4	KM Value [mM]
2	Metals/Ions
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
7	Organism
5	Pathway
2	pH Optimum
1	Purification (Commentary)
1	Reaction
5	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
4	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Reference

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Reference on EC 6.3.1.15 - 8-demethylnovobiocic acid synthase

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721597

Pacholec, M.; Tao, J.; Walsh, C.T.

CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis

Biochemistry

14969-14976

2005

Streptomyces niveus

16274243

722616

Steffensky, M.; Li, S.M.; Heide, L.

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891

J. Biol. Chem.

275

21754-21760

2000

Streptomyces niveus (Q9L9F6), Streptomyces niveus NCIMB 11891 (Q9L9F6)

10801869

723619

Pi, N.; Meyers, C.L.; Pacholec, M.; Walsh, C.T.; Leary, J.A.

Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton

Proc. Natl. Acad. Sci. USA

101

10036-10041

2004

Streptomyces niveus (Q9L9F6), Streptomyces niveus NCIMB 11891 (Q9L9F6)

15218104