6.3.1.15: 8-demethylnovobiocic acid synthase

This is an abbreviated version!
For detailed information about 8-demethylnovobiocic acid synthase, go to the full flat file.

Reaction

Synonyms

8-demethylnovobiocic acid synthetase, 8-desmethyl-novobiocic acid synthetase, NovL, novobiocin ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

                6.3.1.15 8-demethylnovobiocic acid synthase

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Results	in table
24	AA Sequence
1	Cloned(Commentary)
4	General Information
1	Inhibitors
2	kcat/KM [mM/s]
4	KM Value [mM]
2	Metals/Ions
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
7	Organism
5	Pathway
2	pH Optimum
1	Purification (Commentary)
1	Reaction
5	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
4	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.1.15 - 8-demethylnovobiocic acid synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin

AMP + diphosphate + 8-demethylnovobiocic acid

Streptomyces niveus

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the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin

721597

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