6.3.1.13: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

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For detailed information about L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, go to the full flat file.

Reaction

Synonyms

Cys:GlcN-Ins ligase, cysS2, cysteine ligase, L-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, More, MSH ligase, MshC, MshC ligase, MTCY261.29c, mycothiol cysteine ligase, mycothiol ligase, Rv2130c

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

                6.3.1.13 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

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Results	in table
4285	AA Sequence
8	Application
1	CAS Registry Number
6	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
2	Expression
11	General Information
2	IC50 Value
26	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
4	Metals/Ions
3	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
25	Organism
1	Pathway
3	pH Optimum
6	Protein Variants
4	Purification (Commentary)
4	Reaction
17	Reference
6	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
1	Subunits
38	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.1.13 - L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

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SYSTEMATIC NAME

IUBMB Comments

L-cysteine:1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol ligase (AMP-forming)

This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. The enzyme may represent a novel target for new classes of antituberculars [2].