6.3.1.13: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

This is an abbreviated version!
For detailed information about L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, go to the full flat file.

Word Map on EC 6.3.1.13

6.3.1.13

gsh

oxygenase-1

2-related

nadph:quinone

gamma-glutamate

nrf2-are

kelch-like

nf-e2-related

ech-associated

oxidoreductase-1

accys-glcn-ins

erythroid-2-related

drug development

hemeoxygenase-1

pharmacology

Reaction

1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol

1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol

Synonyms

Cys:GlcN-Ins ligase, cysS2, cysteine ligase, L-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, More, MSH ligase, MshC, MshC ligase, MTCY261.29c, mycothiol cysteine ligase, mycothiol ligase, Rv2130c

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.13 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

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Results	in table
4285	AA Sequence
8	Application
1	CAS Registry Number
6	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
2	Expression
11	General Information
2	IC50 Value
26	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
4	Metals/Ions
3	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
25	Organism
1	Pathway
3	pH Optimum
6	Protein Variants
4	Purification (Commentary)
4	Reaction
17	Reference
6	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
1	Subunits
38	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

KM Value

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KM Value on EC 6.3.1.13 - L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

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0.16

1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol

Mycolicibacterium smegmatis

pH 7.8, 25°C, recombinant enzyme

672220

0.072

1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside

Mycolicibacterium smegmatis

pH 7.5, 37°C

650166

1.8

ATP

Mycolicibacterium smegmatis

pH 7.8, 25°C, recombinant enzyme

672220

0.04 - 0.1

L-cysteine

2 entries

additional information

Mycolicibacterium smegmatis

steady-state and pre-steady-state kinetic analysis, single-turnover reactions of the first and second half reactions

672220