6.3.1.12: D-aspartate ligase

This is an abbreviated version!
For detailed information about D-aspartate ligase, go to the full flat file.

Word Map on EC 6.3.1.12

6.3.1.12

enterococcus

multiresistant

faecalis

peptidoglycan

atp-grasp

narrow-spectrum

faecium

bond-forming

medicine

drug development

Reaction

[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n

[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n

Synonyms

aslA, Aslfm, D-aspartic acid-activating enzyme, UDP-MurNAc-pentapeptide:D-aspartate ligase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.12 D-aspartate ligase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
168	AA Sequence
4	Application
2	Cloned(Commentary)
1	Cofactor
2	General Information
37	Inhibitors
2	KM Value [mM]
2	Localization
3	Metals/Ions
3	Natural Substrates/ Products (Substrates)
7	Organism
2	Pathway
2	pH Optimum
1	pH Range
5	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
1	Storage Stability
7	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 6.3.1.12 - D-aspartate ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Natural Substrate Search

ATP + D-aspartate + [beta-GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n

[beta-GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate

Enterococcus faecium

the enzyme is responsible for the addition of D-aspartic acid onto the peptidoglycan precursor. specifically ligates the beta-carboxylate of D-Asp to the epsilon-amino group of L-Lys in the nucleotide precursor UDP-N-acetylmuramyl-pentapeptide

669439

ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n

[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate

2 entries