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6.3.1.12: D-aspartate ligase

This is an abbreviated version!
For detailed information about D-aspartate ligase, go to the full flat file.

Word Map on EC 6.3.1.12

Reaction

ATP
+
D-Aspartate
 +
[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n
=
[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n
 +
ADP
 +
phosphate

Synonyms

aslA, Aslfm, D-aspartic acid-activating enzyme, UDP-MurNAc-pentapeptide:D-aspartate ligase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.12 D-aspartate ligase

Inhibitors

Inhibitors on EC 6.3.1.12 - D-aspartate ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(4-methylphenyl)-5-[5-(3-methylphenyl)-1H-pyrazol-4-yl]-1H-tetrazole
-
-
1H-imidazol-4-yl(diphenyl)methanol
-
-
2-amino-N,N-bis(pyridin-2-ylmethyl)oxazole-5-carboxamide
-
-
2-amino-N,N-dibenzyl-4-methylthiazole-5-carboxamide
-
-
2-amino-N,N-dibenzyloxazole-5-carboxamide
-
-
2-amino-N,N-dibenzylthiazole-5-carboxamide
-
-
2-amino-N,N-dibutyloxazole-5-carboxamide
-
-
2-amino-N-(1H-benzo[d]imidazol-2-yl)oxazole-5-carboxamide
-
-
2-amino-N-benzyl-N-butyloxazole-5-carboxamide
-
-
2-amino-N-ethyl-N-(pyridin-4-ylmethyl)oxazole-5-carboxamide
-
-
2-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzimidazol-1-yl]-N-methyl-N-phenylacetamide
-
-
2-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzimidazol-1-yl]-N-phenylacetamide
-
-
2-[2-[(methylsulfonyl)amino]-1,3-thiazol-4-yl]-N,N-bis(thiophen-2-ylmethyl)acetamide
-
-
4-phenyl-5-(1-phenyl-1H-tetrazol-5-yl)pyrimidin-2-amine
-
-
5-(diphenylphosphoryl)-1,3,4-thiadiazol-2-amine
-
-
6-[(2,4-dichlorobenzyl)sulfanyl]-9H-purin-2-amine
-
-
6-[(2,6-dichlorobenzyl)sulfanyl]-9H-purin-2-amine
-
-
N,N-dibenzyl-9H-purin-6-amine
-
-
N-((1H-indol-5-yl)methyl)-2-amino-N-(3,5-dibromobenzyl)oxazole-5-carboxamide
-
-
N-((1H-indol-5-yl)methyl)-2-aminooxazole-5-carboxamide
-
-
N-(furan-2-ylmethyl)-5-hydroxy-N-(thiophen-2-ylmethyl)pyrazine-2-carboxamide
-
-
N-(furan-2-ylmethyl)-6-hydroxy-N-(thiophen-2-ylmethyl)pyridine-3-carboxamide
-
-
N-benzyl-N-(2,6-dichlorobenzyl)-9H-purin-6-amine
-
-
N-benzyl-N-(4-chlorobenzyl)-9H-purin-6-amine
-
-
N4-(2,3-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-(2,4-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-(2,4-difluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-(2,6-difluoro-3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-(2,6-difluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-(2-chloro-6-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-[(2-chloropyridin-3-yl)methyl]-N4-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N4-[(5-chlorothiophen-2-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
-
-
N6-(1,3-benzodioxol-5-ylmethyl)-9H-purine-2,6-diamine
-
-
N6-(2,4-dichlorobenzyl)-9H-purine-2,6-diamine
-
-
N6-(2,4-dimethoxybenzyl)-9H-purine-2,6-diamine
-
-
N6-(3,4-dichlorobenzyl)-9H-purine-2,6-diamine
-
-
additional information
-
screening of a series of amino-oxazoles derived from bacterial biotin carboxylase inhibitors, the compounds show low micromolar activity against D-aspartate ligase. Screening of enzyme inhibitors with 7-amino-9H-purine and 7-amino-1H-pyrazolo[3,4-d]pyrimidine scaffolds, the compounds are competitive with respect to the ATP molecule
-