6.3.1.11: glutamate-putrescine ligase
This is an abbreviated version!
For detailed information about glutamate-putrescine ligase, go to the full flat file.
Word Map on EC 6.3.1.11
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6.3.1.11
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interferon-inducible
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interferon-stimulated
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ifn-inducible
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polyi:c
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reticulum-associated
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ifn-stimulated
- 6.3.1.11
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interferon-inducible
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interferon-stimulated
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ifn-inducible
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polyi:c
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reticulum-associated
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ifn-stimulated
Reaction
Synonyms
gamma-Glu-Put synthetase, gamma-glutamylputrescine synthetase, PuuA, YcjK
ECTree
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Substrates Products
Substrates Products on EC 6.3.1.11 - glutamate-putrescine ligase
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REACTION DIAGRAM
ATP + glutamate + putrescine
ADP + phosphate + gamma-L-glutamylputrescine
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the enzyme is involved in a putrescine utilization pathway
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ADP + phosphate + gamma-L-glutamylputrescine
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ATP + L-glutamate + putrescine
ADP + phosphate + gamma-L-glutamylputrescine
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the enzyme catalyzes the gamma-glutamylation of putrescine, the first step in a different putrescine utilization pathway involving gamma-glutamylated intermediates, the Puu pathway, in Escherichia coli, overview. The intracellular concentration of putrescine is probably optimized by PuuA transcriptionally and posttranslationally and excess putrescine is converted to a nutrient source by the Puu pathway, regulation, overview
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ATP + L-glutamate + putrescine
ADP + phosphate + gamma-L-glutamylputrescine
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PuuA exhibits the highest activity for putrescine, which has four carbon atoms, and activity drops when the methylene chain of diamine is longer or shorter than C4
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intracellular polyamine profile of various strains relevant to puuA, overview
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additional information
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when any one of the substrates and a cofactor , i.e. putrescine, glutamate, ATP, and the metal ion, are omitted from the reaction mixture, gamma-Glu-Put is not formed
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