6.3.1.11: glutamate-putrescine ligase

This is an abbreviated version!
For detailed information about glutamate-putrescine ligase, go to the full flat file.

Word Map on EC 6.3.1.11

6.3.1.11

interferon-inducible

interferon-stimulated

ifn-inducible

polyi:c

reticulum-associated

ifn-stimulated

Reaction

Synonyms

gamma-Glu-Put synthetase, gamma-glutamylputrescine synthetase, PuuA, YcjK

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.11 glutamate-putrescine ligase

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Results	in table
1	Activating Compound
1345	AA Sequence
1	Cloned(Commentary)
1	Cofactor
3	KM Value [mM]
3	Metals/Ions
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
2	Organism
5	Pathway
1	PDB ID
1	pH Optimum
6	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
2	Reference
1	Specific Activity [micromol/min/mg]
6	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.1.11 - glutamate-putrescine ligase

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ATP + glutamate + putrescine

ADP + phosphate + gamma-L-glutamylputrescine

Escherichia coli

the enzyme is involved in a putrescine utilization pathway

659502

ATP + L-glutamate + putrescine

ADP + phosphate + gamma-L-glutamylputrescine

Escherichia coli K-12

the enzyme catalyzes the gamma-glutamylation of putrescine, the first step in a different putrescine utilization pathway involving gamma-glutamylated intermediates, the Puu pathway, in Escherichia coli, overview. The intracellular concentration of putrescine is probably optimized by PuuA transcriptionally and posttranslationally and excess putrescine is converted to a nutrient source by the Puu pathway, regulation, overview

693086

additional information

Escherichia coli K-12

intracellular polyamine profile of various strains relevant to puuA, overview

693086