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6.2.1.45: E1 ubiquitin-activating enzyme

This is an abbreviated version!
For detailed information about E1 ubiquitin-activating enzyme, go to the full flat file.

Word Map on EC 6.2.1.45

Reaction

ATP
+
ubiquitin
 +
[E1 ubiquitin-activating enzyme]-L-cysteine
=
AMP
 +
diphosphate
 +
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine

Synonyms

AtUBA1, AtUBA2, E1, E1 ubiquitin-activating enzyme, HsUba1a, non-canonical ubiquitin activating enzyme, SUMO E1, UB activating enzyme, Ub E1 activating enzyme, Ub-activating enzyme, Ub-activating ligase, Uba1, Uba1/E1, Uba1a, UBA1p, UBA2, UBA5, Uba6, UBA7, UBE1, UBE1DC1, UBE1DC1A, UBE1DC1B, UBE1L, UBE1L2, ubiquitin activating enzyme, ubiquitin activating enzyme 2, ubiquitin activating enzyme E1, ubiquitin activating enzyme E1-like, ubiquitin E1, ubiquitin protein ligase E1, Ubiquitin-activating enzyme, ubiquitin-activating enzyme (E1), ubiquitin-activating enzyme 1, ubiquitin-activating enzyme 5, ubiquitin-activating enzyme 6, ubiquitin-activating enzyme E1, ubiquitin-activating enzyme E1 domain-containing protein 1, ubiquitin-activating enzyme E1-domain containing 1, ubiquitin-activating enzyme, UBE1, ubiquitin-conjugating enzyme, ubiquitin-like modifier-activating enzyme 1, ubiquitin-like modifier-activating enzyme 5, ubiquitin-like modifier-activating enzyme 6, ubiquitin-like modifier-activating enzyme 7 isoform X2

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.45 E1 ubiquitin-activating enzyme

Source Tissue

Source Tissue on EC 6.2.1.45 - E1 ubiquitin-activating enzyme

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
mouse embryo fibroblast cell, thermosensitive for ubiquitin-activating enzyme E1
Manually annotated by BRENDA team
-
expression level of the CrUBE1 gene in anthers of cv. Shatangju is approximately 10fold higher than in anthers of cv. Wuzishatangju
Manually annotated by BRENDA team
-
high enzyme expression level
Manually annotated by BRENDA team
-
very low expression
Manually annotated by BRENDA team
embryonic kidney
Manually annotated by BRENDA team
-
very low expression
Manually annotated by BRENDA team
-
very low expression
Manually annotated by BRENDA team
colon carcinoma cell
Manually annotated by BRENDA team
ovine thymuses are sampled on day 16 of the estrous cycle and on days 13, 16 and 25 of gestation, and UBE1L is detected by real-time quantitative PCR, Western blot and immunohistochemistry. The expression of UBE1L is declined during early pregnancy
Manually annotated by BRENDA team
additional information