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6.2.1.36: 3-hydroxypropionyl-CoA synthase

This is an abbreviated version!
For detailed information about 3-hydroxypropionyl-CoA synthase, go to the full flat file.

Reaction

3-hydroxypropanoate
+
ATP
+
CoA
=
3-hydroxypropanoyl-CoA
+
AMP
+
diphosphate

Synonyms

3-hydroxypropionyl-CoA synthetase (AMP-forming)

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.36 3-hydroxypropionyl-CoA synthase

Systematic Name

Systematic Name on EC 6.2.1.36 - 3-hydroxypropionyl-CoA synthase

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SYSTEMATIC NAME
IUBMB Comments
3-hydroxypropionate:CoA ligase (AMP-forming)
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.