6.2.1.30: phenylacetate-CoA ligase
This is an abbreviated version!
For detailed information about phenylacetate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.30
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6.2.1.30
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phenylacetic
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penicillin
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chrysogenum
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putida
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ligases
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isopenicillin
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cenocepacia
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phenylglyoxylate
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benzoyl-coa
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denitrifying
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synthesis
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3-hydroxyphenylacetic
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phenylacetaldehyde
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analysis
- 6.2.1.30
-
phenylacetic
- penicillin
- chrysogenum
- putida
- ligases
- isopenicillin
- cenocepacia
- phenylglyoxylate
- benzoyl-coa
-
denitrifying
- synthesis
-
3-hydroxyphenylacetic
- phenylacetaldehyde
- analysis
Reaction
Synonyms
EC 6.2.1.21, More, PA-CoA ligase, PAA-CoA ligase, PaaF2, PaaK1, PaaK2, PCL, phenyl/phenoxyacetic acid activating enzyme, phenyl/phenoxyacetyl-CoA-ligase, phenylacetyl CoA ligase, phenylacetyl-CoA ligase, phenylacetyl-CoA ligase (AMP-forming), phenylacetyl-coenzyme A ligase, Phl protein, phlB, PhlC, styrene-specific PA-CoA ligase, synthetase, phenacyl coenzyme A
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Application
Application on EC 6.2.1.30 - phenylacetate-CoA ligase
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analysis
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determination of of microbody-borne enzymes by analysis of putative microbody targeting singals and a proteomics based inventory of Penicillium chrysogenum microbody matrix proteins using nano-LC-MS/MS analysis
synthesis
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the expression of the heterologous enzyme phenylacetyl-CoA ligase, involved in catabolism of a penicillin precursor, is a useful strategy for improving the biosynthetic machinery of this fungus
synthesis
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engineering of Hansenula polymorpha for secretion of penicillin. Introduction of the Penicilliumchrysogenum gene encoding the non-ribosomal peptide synthetase delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase in Hansenula polymorpha, results in the production of active enzyme, when co-expressed with the Bacillus subtilis sfp gene encoding a phosphopantetheinyl transferase that activates ACVS. Co-expression with the Penicillium chrysogenum genes encoding the cytosolic enzyme isopenicillin N synthase as well as the two peroxisomal enzymes isopenicillin N acyl transferase and phenylacetyl CoA ligase results in production of biologically active penicillin, which is efficiently secreted. The amount of secreted penicillin is approximately 1 mg/l. Penicillin production is decreased over 2fold in a yeast strain lacking peroxisomes