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6.2.1.3: long-chain-fatty-acid-CoA ligase

This is an abbreviated version!
For detailed information about long-chain-fatty-acid-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.3

Reaction

ATP
+
a long-chain fatty acid
 +
CoA
=
AMP
 +
diphosphate
 +
a long-chain fatty acyl-CoA

Synonyms

Abll, ACS, ACS-3, ACS-5, ACS1, ACS2, ACS3, ACS4, ACS5, ACS6, AcsA, ACSL, ACSL1, ACSL2, ACSL3, ACSL4, ACSL5, ACSL6, ACSL6 protein, ACSL6_v1, ACSL6_v2, ACSL6_v3, ACSL6_v5, ACSL6_v6, Acsvl1, Acyl coenzyme A synthetase, Acyl-activating enzyme, Acyl-CoA ligase, acyl-CoA synthase-3, Acyl-CoA synthetase, Acyl-CoA synthetase 3, acyl-CoA synthetase 4, acyl-CoA synthetase 5, acyl-CoA synthetase long-chain, acyl-CoA synthetase long-chain family member 4, acyl-CoA synthetase-1, Acyl-coenzyme A ligase, BGR, bubblegum-related protein, CG6178, dAcsl, FAA1, Faa1p, Faa2p, Faa3p, Faa4p, FaaA, FaaB, Facl1, Facl2, FACL3, FACL3/ACS3, FACL4, FACS, FAdD, FadD2, Fat1p, Fat2p, FatA, FatB, FatC, FatD, FATP, FATP2, FATP4, Fatty acid CoA ligase, fatty acid CoA ligase: AMP forming, fatty acid CoA synthetase, AMP forming, fatty acid thiokinase, Fatty acid thiokinase (long chain), fatty acid transport protein, fatty acid transport protein 2, fatty acid transport protein 4, fatty acid-CoA ligase 4, fatty acid:CoA ligase, AMP-forming, fatty acyl-CoA synthetase, Fatty acyl-coenzyme A synthetase, Fatty-acyl-CoA ligase, gonadotropin-regulated long chain acyl-CoA synthetase, gonadotropin-regulated long-chain acyl CoA synthetase, GR-LACS, LACS, LACS1, LACS2, LACS3, LACS4, LACS6, LACS7, LACS9, LC-FACS, LCFA synthetase, LCFACoAS, lipidosin, long chain acyl-CoA synthetase, long chain acyl-CoA synthetase 1, long chain acyl-CoA synthetase 2, long chain acyl-CoA synthetase 3, long chain acyl-CoA synthetase 4, long chain acyl-CoA synthetase 5, Long chain fatty acyl CoA ligase, Long chain fatty acyl-CoA synthetase, long chain fatty acyl-CoA synthetase 5, long fatty acyl-CoA synthetase, Long-chain acyl CoA synthetase, long-chain acyl coenzyme A synthetase 1, long-chain acyl-CoA synthetase, long-chain acyl-CoA synthetase 1, long-chain acyl-CoA synthetase 4, long-chain acyl-CoA synthetase 5, long-chain acyl-CoA synthetase 6, Long-chain acyl-CoA synthetase I, Long-chain acyl-CoA synthetase II, long-chain acyl-CoA synthetase-1, long-chain acyl-CoA synthetases, Long-chain acyl-coenzyme A synthetase, long-chain fatty acid CoA ligase, long-chain fatty acid:CoA ligase, long-chain fatty acyl coenzyme A ligase, Long-chain fatty acyl coenzyme A synthetase, long-chain fatty acyl-CoA synthetase, long-chain fatty-acid-CoA ligase 3, long-chain polyunsaturated fatty acid acyl-coenzyme A synthetase, luciferase-like gene, luciferase-like protein, mACS4, MenE, More, Oleoyl-CoA synthetase, OPC-8:CoA ligase, OPCL1, Palmitoyl coenzyme A synthetase, Palmitoyl-CoA ligase, Palmityl-coenzyme A synthetase, PhpLL1, Pristanoyl-CoA synthetase, protein At1g20510, putative long-chain acyl-CoA synthetase, R-ibuprofenoyl-CoA synthetase, Stearoyl-CoA synthetase, TbACS1, TbACS3, TbACS4, Thiokinase, very long chain acyl-CoA synthetase 1, YBR041W, YBR222C, YER015W

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.3 long-chain-fatty-acid-CoA ligase

IC50 Value

IC50 Value on EC 6.2.1.3 - long-chain-fatty-acid-CoA ligase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0057
5'-deoxy-5'-[([(1E)-5-[2-(methoxycarbonyl)phenyl]-5-oxopent-1-en-1-yl]sulfonyl)amino]adenosine
Mycobacterium tuberculosis
-
-
0.2
5'-deoxy-5'-[([(1E)-5-[2-(methoxycarbonyl)phenyl]hexa-1,5-dien-1-yl]sulfonyl)amino]adenosine
Mycobacterium tuberculosis
-
above
0.034
5'-deoxy-5'-[([4-[2-(methoxycarbonyl)phenyl]-4-oxobutanoyl]sulfamoyl)amino]adenosine
Mycobacterium tuberculosis
-
-
0.2
5'-deoxy-5'-[([4-[2-(methoxycarbonyl)phenyl]pent-4-enoyl]sulfamoyl)amino]adenosine
Mycobacterium tuberculosis
-
above
0.038
5'-O-([4-[2-(methoxycarbonyl)phenyl]-4-oxobutanoyl]sulfamoyl)adenosine
Mycobacterium tuberculosis
-
-
0.2
5'-O-([4-[2-(methoxycarbonyl)phenyl]pent-4-enoyl]sulfamoyl)adenosine
Mycobacterium tuberculosis
-
above
0.025
cis-9,10-methylene octadecanoic acid
Rattus norvegicus
-
IC50: 0.025 mM for ACS1-Flag fusion protein, 0.03-0.04 mM for ACS4-Flag fusion protein, no effect on ACS5-Flag fusion protein
0.05
GW1929
Rattus norvegicus
-
IC50: above 0.05 mM for ACS1-Flag fusion protein, 0.05 mM for ACS4-Flag fusion protein, no effect on ACS5-Flag fusion protein
0.0015
pioglitazone
Rattus norvegicus
-
IC50: 0.0015 mM for ACS1-Flag fusion protein, no effect on ACS4-Flag fusion protein and ACS5-Flag fusion protein
0.0005
rosiglitazone
Rattus norvegicus
-
IC50: 0.0005 mM for ACS1-Flag fusion protein, no effect on ACS4-Flag fusion protein and ACS5-Flag fusion protein
0.00016 - 0.00018
Triacsin A
0.0001 - 0.03
Triacsin C
0.0015 - 0.02
troglitazone