6.2.1.26: O-succinylbenzoate-CoA ligase
This is an abbreviated version!
For detailed information about O-succinylbenzoate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.26
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6.2.1.26
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menaquinone
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o-succinylbenzoic
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1,4-dihydroxy-2-naphthoic
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half-reaction
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drug development
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anthracis
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semi-automated
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wells
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5'-triphosphate
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mono-phosphate
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adenylyltransferase
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phylloquinone
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backside
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benzoic
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mononucleotide
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phlei
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dihydroxynaphthoate
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in-line
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unattended
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ping-pong
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isochorismate
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ultra-high
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thioesterification
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scalable
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liquid-handling
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malachite
- 6.2.1.26
- menaquinone
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o-succinylbenzoic
-
1,4-dihydroxy-2-naphthoic
-
half-reaction
- drug development
- anthracis
-
semi-automated
-
wells
- 5'-triphosphate
-
mono-phosphate
- adenylyltransferase
- phylloquinone
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backside
-
benzoic
- mononucleotide
- phlei
-
dihydroxynaphthoate
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in-line
-
unattended
-
ping-pong
- isochorismate
-
ultra-high
-
thioesterification
-
scalable
-
liquid-handling
- malachite
Reaction
Synonyms
AAE14, acyl-activating enzyme 14, BsMenE, MenE, O-succinylbenzoate-CoA synthase, o-succinylbenzoate-CoA synthetase, o-succinylbenzoyl-CoA synthetase, o-succinylbenzoyl-coenzyme A ligase, o-succinylbenzoyl-coenzyme A synthetase, OSB-CoA ligase, OSB-CoA synthetase, OSB:CoA ligase, synthetase, o-succinylbenzoyl coenzyme A
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Substrates Products
Substrates Products on EC 6.2.1.26 - O-succinylbenzoate-CoA ligase
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REACTION DIAGRAM
4-[2-(trifluoromethyl)phenyl]-4-oxobutyric acid + CoA
AMP + diphosphate + 4-[2-(trifluoromethyl)phenyl]-4-oxobutyryl-CoA
a substrate analogue, 100fold less active than 2-succinylbenzoate
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-
?
ATP + 2-succinylbenzoate + dephospho-CoA
AMP + 2-succinylbenzoyldephospho-CoA + diphosphate
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96% of the activity with CoA
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-
?
ATP + benzoylpropionic acid + CoA
AMP + benzoylpropionyl-CoA + diphosphate
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21.6% of the activity with o-succinylbenzoate
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-
?
ATP + o-malonylbenzoate + CoA
AMP + o-malonylbenzoyl-CoA + diphosphate
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11.6% of the activity with o-succinylnemzoate
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-
?
CTP + o-succinylbenzoate + CoA
CMP + diphosphate + o-succinylbenzoyl-CoA
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13.5% of the activity with ATP
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-
?
GTP + o-succinylbenzoate + CoA
GMP + diphosphate + o-succinylbenzoyl-CoA
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13.4% of the activity with ATP
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-
?
ITP + o-succinylbenzoate + CoA
IMP + diphosphate + o-succinylbenzoyl-CoA
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10.9% of the activity with ATP
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-
?
TTP + o-succinylbenzoate + CoA
TMP + diphosphate + o-succinylbenzoyl-CoA
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12.1% of the activity with ATP
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-
?
UTP + o-succinylbenzoate + CoA
UMP + diphosphate + o-succinylbenzoyl-CoA
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12.3% of the activity with ATP
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?
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
OSB-CoA ligase acts in phylloquinone synthesis, pathway for phylloquinone synthesis, overview
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-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
ATP-dependent condensation of o-succinylbenzoate, and CoA to form o-succinylbenzoyl-CoA, the fourth step of the menaquinone biosynthetic pathway in Bacillus anthracis
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-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
substrate specificity and binding structure, overview
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
o-succinylbenzoyl-CoA is a highly unstable compound which spontaneously converts to o-succinylbenzoate-spirolactone in absence of 1,4-dihydroxy-2-naphthoic acid synthase
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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the o-succinylbenzoyl conenzyme A ester is unstable at alkaline and neutral pH, but is fairly stable under acid conditions
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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incubation of the purified enzyme at different pH values gives a varying ratio of o-succinylbenzoyl-CoA to o-succinylbenzoyl-diCoA. No formation of o-succinylbenzoyl-2-CoA. No formation of ADP
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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the o-succinylbenzoyl-CoA derivative is rather unstable, under a variety of conditions it is converted to a spirodilactone form of o-succinylbenzoate
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis
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?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 2-succinylbenzoyl-CoA
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-
-
-
?
AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
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-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
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-
-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
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-
-
-
?
ATP + 2-succinylbenzoate + CoA
AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
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-
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?
?
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His341 plays an important role in catalysis since it is probably involved in the binding of ATP to the enzyme
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?
additional information
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no activity with: o-malonylbenzoic acid, benzoylpropionic acid, benzoic acid, o-acetylbenzoic acid, phthalic acid and p-coumaric acid
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?