6.2.1.26: O-succinylbenzoate-CoA ligase

This is an abbreviated version!
For detailed information about O-succinylbenzoate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.26

6.2.1.26

menaquinone

o-succinylbenzoic

1,4-dihydroxy-2-naphthoic

half-reaction

drug development

anthracis

semi-automated

wells

5'-triphosphate

mono-phosphate

adenylyltransferase

phylloquinone

backside

benzoic

mononucleotide

phlei

dihydroxynaphthoate

in-line

unattended

ping-pong

isochorismate

ultra-high

thioesterification

scalable

liquid-handling

malachite

Reaction

Synonyms

AAE14, acyl-activating enzyme 14, BsMenE, MenE, O-succinylbenzoate-CoA synthase, o-succinylbenzoate-CoA synthetase, o-succinylbenzoyl-CoA synthetase, o-succinylbenzoyl-coenzyme A ligase, o-succinylbenzoyl-coenzyme A synthetase, OSB-CoA ligase, OSB-CoA synthetase, OSB:CoA ligase, synthetase, o-succinylbenzoyl coenzyme A

ECTree

6 Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.26 O-succinylbenzoate-CoA ligase

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Results	in table
1	Activating Compound
7425	AA Sequence
5	Application
1	CAS Registry Number
4	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
12	General Information
26	IC50 Value
45	Inhibitors
10	Ki Value [mM]
39	KM Value [mM]
2	Localization
16	Metals/Ions
3	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
17	Organism
6	Pathway
24	PDB ID
4	pH Optimum
1	pH Range
1	pI Value
16	Protein Variants
4	Purification (Commentary)
7	Reaction
1	Reaction Type
17	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
35	Substrates and Products (Substrate)
5	Subunits
26	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
30	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 6.2.1.26 - O-succinylbenzoate-CoA ligase

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CoA

Bacillus anthracis

Q81K97

CoA, the last substrate to bind, strongly activates the first half-reaction after the first round of turnover, by CoA stabilizing conformations of the enzyme in the F form, which slowly isomerize back to the E form

690915