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6.2.1.20: long-chain-fatty-acid-[acyl-carrier-protein] ligase

This is an abbreviated version!
For detailed information about long-chain-fatty-acid-[acyl-carrier-protein] ligase, go to the full flat file.

Word Map on EC 6.2.1.20

Reaction

ATP
+
a long-chain fatty acid
+
an [acyl-carrier protein]
=
AMP
+
diphosphate
+
a long-chain acyl-[acyl-carrier protein]

Synonyms

AAE15, AAS, AasC, AasS, ACP synthase, AcpS, ACSL, acyl carrier protein synthase, acyl-ACP synthase, Acyl-ACP synthetase, Acyl-acyl carrier protein synthetase, Acyl-CoA ligase, Acyl-CoA synthetase, Acyl-[acyl carrier protein] synthetase, Acyl-[acyl-carrier-protein]synthetase, At4g14070, CT776, CTO_0846, LipA, PfACP, slr1609, Stearoyl-ACP synthetase, Synthetase, acyl-[acyl carrier protein]

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.20 long-chain-fatty-acid-[acyl-carrier-protein] ligase

Reference

Reference on EC 6.2.1.20 - long-chain-fatty-acid-[acyl-carrier-protein] ligase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rock, C.O.; Cronan, J.E.
Acyl-acyl carrier protein synthetase from Escherichia coli
Methods Enzymol.
71
163-168
1981
Escherichia coli
Manually annotated by BRENDA team
Rock, C.O.; Cronan, J.E.
Solubilization, purification, and salt activation of acyl-acyl carrier protein synthetase from Escherichia coli
J. Biol. Chem.
254
7116-7122
1979
Escherichia coli
Manually annotated by BRENDA team
Cooper, C.L.; Li Hsu; Jackowski, S.; Rock, C.O.
2-Acylglycerolphosphoethanolamine acyltransferase/acyl-acyl carrier protein synthetase is a membrane-associated acyl carrier binding protein
J. Biol. Chem.
264
7384-7389
1989
Escherichia coli
Manually annotated by BRENDA team
Kuo, T.M.; Ohlrogge, J.B.
Acylation of plant carrier proteins by acyl-acyl carrier protein synthetase from Escherichia coli
Arch. Biochem. Biophys.
230
110-116
1984
Escherichia coli
Manually annotated by BRENDA team
Lessire, R.; Cassagne, C.
Direct synthesis of stearoyl-acyl carrier protein from stearate by microsomes from Allium porrum epidermal cells
Plant Sci. Lett.
14
43-48
1979
Allium ampeloprasum
-
Manually annotated by BRENDA team
Ray, T.K.; Cronan, J.E.
Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli
Proc. Natl. Acad. Sci. USA
73
4374-4378
1976
Escherichia coli
Manually annotated by BRENDA team
Fice, D.; Shen, Z.; Byers, D.M.
Purification and characterization of fatty acyl-acyl carrier protein synthetase from Vibrio harveyi
J. Bacteriol.
175
1865-1870
1993
Vibrio harveyi
Manually annotated by BRENDA team
Shen, Z.; Fice, D.; Byers, D.M.
Preparation of fatty-acylated derivatives of acyl carrier protein using Vibrio harveyi acyl-ACP synthetase
Anal. Biochem.
204
34-39
1992
Vibrio harveyi, Vibrio harveyi B392
Manually annotated by BRENDA team
Hsu, L.; Jackowski, S.; Rock, C.O.
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acylglycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity
J. Biol. Chem.
266
13783-13788
1991
Escherichia coli
Manually annotated by BRENDA team
Flaman, A.S.; Chen, J.M.; Van Iderstine, S.C.; Byers, D.M.
Site-directed mutagenesis of acyl carrier protein (ACP) reveals amino acid residues involved in ACP structure and acyl-ACP synthetase activity
J. Biol. Chem.
276
35934-35939
2001
Vibrio harveyi
Manually annotated by BRENDA team
Gong, H.; Byers, D.M.
Glutamate-41 of Vibrio harveyi acyl carrier protein is essential for fatty acid synthase but not acyl-ACP synthetase activity
Biochem. Biophys. Res. Commun.
302
35-40
2003
Vibrio harveyi
Manually annotated by BRENDA team
Gangar, A.; Karande, A.A.; Rajasekharan, R.
Purification and characterization of acyl-acyl carrier protein synthetase from oleaginous yeast and its role in triacylglycerol biosynthesis
Biochem. J.
360
471-479
2001
Rhodotorula glutinis
Manually annotated by BRENDA team
Shanklin, J.
Overexpression and purification of the Escherichia coli inner membrane enzyme acyl-acyl carrier protein synthase in an active form
Protein Expr. Purif.
18
355-360
2000
Escherichia coli
Manually annotated by BRENDA team
Sharma, S.K.; Modak, R.; Sharma, S.; Sharma, A.K.; Sarma, S.P.; Surolia, A.; Surolia, N.
A novel approach for over-expression, characterization, and isotopic enrichment of a homogeneous species of acyl carrier protein from Plasmodium falciparum
Biochem. Biophys. Res. Commun.
330
1019-1026
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Koo, A.J.; Fulda, M.; Browse, J.; Ohlrogge, J.B.
Identification of a plastid acyl-acyl carrier protein synthetase in Arabidopsis and its role in the activation and elongation of exogenous fatty acids
Plant J.
44
620-632
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Jiang, Y.; Chan, C.H.; Cronan, J.E.
The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family
Biochemistry
45
10008-10019
2006
Vibrio harveyi (Q00IB3), Vibrio harveyi, Vibrio harveyi B392 (Q00IB3), Vibrio harveyi B392
Manually annotated by BRENDA team
Gong, H.; Murphy, A.; McMaster, C.R.; Byers, D.M.
Neutralization of acidic residues in helix II stabilizes the folded conformation of acyl carrier protein and variably alters its function with different enzymes
J. Biol. Chem.
282
4494-4503
2007
Vibrio harveyi
Manually annotated by BRENDA team
Jiang, Y.; Morgan-Kiss, R.M.; Campbell, J.W.; Chan, C.H.; Cronan, J.E.
Expression of Vibrio harveyi acyl-ACP synthetase allows efficient entry of exogenous fatty acids into the Escherichia coli fatty acid and lipid A synthetic pathways
Biochemistry
49
718-726
2010
Vibrio harveyi
Manually annotated by BRENDA team
Kaczmarzyk, D.; Fulda, M.
Fatty acid activation in cyanobacteria mediated by acyl-acyl carrier protein synthetase enables fatty acid recycling
Plant Physiol.
152
1598-1610
2010
Synechocystis sp., Synechococcus elongatus (Q31PS1), Synechococcus elongatus
Manually annotated by BRENDA team
Kaczmarzyk, D.; Hudson, E.P.; Fulda, M.
Arabidopsis acyl-acyl carrier protein synthetase AAE15 with medium chain fatty acid specificity is functional in cyanobacteria
AMB Express
6
doi: 10.1186/s13568-016-0178-z
2016
Arabidopsis thaliana (Q8W471)
Manually annotated by BRENDA team
Ma, J.C.; Wu, Y.Q.; Cao, D.; Zhang, W.B.; Wang, H.H.
Only acyl carrier protein 1 (AcpP1) functions in Pseudomonas aeruginosa fatty acid synthesis
Front. Microbiol.
8
2186
2017
Pseudomonas aeruginosa, Vibrio harveyi (Q00IB3)
Manually annotated by BRENDA team
Yao, J.; Dodson, V.J.; Frank, M.W.; Rock, C.O.
Chlamydia trachomatis scavenges host fatty acids for phospholipid synthesis via an acyl-acyl carrier protein synthetase
J. Biol. Chem.
290
22163-22173
2015
Chlamydia trachomatis, Chlamydia trachomatis (O84781), Chlamydia trachomatis D/UW-3/Cx (O84781), Chlamydia trachomatis 434/Bu
Manually annotated by BRENDA team
Takatani, N.; Use, K.; Kato, A.; Ikeda, K.; Kojima, K.; Aichi, M.; Maeda, S.; Omata, T.
Essential role of acyl-ACP synthetase in acclimation of the cyanobacterium Synechococcus elongatus strain PCC 7942 to high-light conditions
Plant Cell Physiol.
56
1608-1615
2015
Synechococcus elongatus, Synechococcus elongatus PCC 7942
Manually annotated by BRENDA team
Paul, S.; Ishida, H.; Nguyen, L.T.; Liu, Z.; Vogel, H.J.
Structural and dynamic characterization of a freestanding acyl carrier protein involved in the biosynthesis of cyclic lipopeptide antibiotics
Protein Sci.
26
946-959
2017
Actinoplanes friuliensis (Q7X541)
Manually annotated by BRENDA team
Soupene, E.; Kuypers, F.A.
Phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis
Sci. Rep.
7
15767
2017
Chlamydia trachomatis (O84781), Chlamydia trachomatis, Chlamydia trachomatis D/UW-3/Cx (O84781)
Manually annotated by BRENDA team