6.2.1.17: propionate-CoA ligase
This is an abbreviated version!
For detailed information about propionate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.17
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6.2.1.17
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acetyl-coa
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propionylation
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3-hydroxypropionate
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chloroflexus
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acryloyl-coa
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butyryl-coa
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methylcitrate
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metallosphaera
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sedula
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aurantiacus
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synthesis
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analysis
- 6.2.1.17
- acetyl-coa
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propionylation
- 3-hydroxypropionate
- chloroflexus
- acryloyl-coa
- butyryl-coa
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methylcitrate
- metallosphaera
- sedula
- aurantiacus
- synthesis
- analysis
Reaction
Synonyms
3-hydroxypropionyl-CoA synthetase, 3-hydroxypropionyl-coenzyme A synthetase, ACSS3, Propionate-CoA synthetase, Propionyl CoA synthetase, Propionyl-CoA synthase, Propionyl-CoA synthetase, Propionyl-coenzyme A synthetase, PrpE, Synthetase, propionyl coenzyme A
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 6.2.1.17 - propionate-CoA ligase
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REACTION DIAGRAM
AMP + diphosphate + 3-hydroxypropanoyl-CoA
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ATP + 3-hydroxypropanoate + CoA
AMP + diphosphate + 3-hydroxypropanoyl-CoA
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-
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?
ATP + 3-hydroxypropanoate + CoA
AMP + diphosphate + 3-hydroxypropanoyl-CoA
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?
AMP + diphosphate + NADP+ + propionyl-CoA
involved in CO2 fixation via 3-hydroxypropionate cycle
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?
ATP + 3-hydroxypropionate + CoA + NADPH
AMP + diphosphate + NADP+ + propionyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
involved in CO2 fixation via 3-hydroxypropionate cycle
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?
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the distinct propionyl CoA synthetase regulated by the concentration of propanoate in portal blood is significant because a primary role of ruminant liver is to synthesize glucose from ruminally derived propanoate
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ATP + propanoate + CoA
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intracellular accumulation of propanoyl-CoA is associated with impairment of important heptic metabolic pathways. Since propanoate absorbed from the intestine can be converted to propanoyl-CoA in the liver, inhibition of propanoyl-CoA synthesis from propanoate and CoA may provide a strategy for decreasing toxicity from plasma propanoate
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ATP + propanoate + CoA
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propanoate resulting from the terminal oxidation of propane to 1-propanol and oxidation of 1-propanol via the propanal dehydrogenase may be further metabolized via propanoyl-CoA synthetase
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ATP + propanoate + CoA
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propanoate resulting from the terminal oxidation of propane to 1-propanol and oxidation of 1-propanol via the propanal dehydrogenase may be further metabolized via propanoyl-CoA synthetase
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ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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required for propionate catabolism
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ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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propionyl-CoA is a potent precursor of epothilone B, a potential anti-cancer agent
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ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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?
ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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required for propionate catabolism
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ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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required for propionate catabolism, recapture of exogenous propionate
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ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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required for propionate catabolism, recapture of exogenous propionate
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?
ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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required for propionate catabolism
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?