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6.2.1.17: propionate-CoA ligase

This is an abbreviated version!
For detailed information about propionate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.17

Reaction

ATP
+
propanoate
+
CoA
=
AMP
+
diphosphate
+
propanoyl-CoA

Synonyms

3-hydroxypropionyl-CoA synthetase, 3-hydroxypropionyl-coenzyme A synthetase, ACSS3, Propionate-CoA synthetase, Propionyl CoA synthetase, Propionyl-CoA synthase, Propionyl-CoA synthetase, Propionyl-coenzyme A synthetase, PrpE, Synthetase, propionyl coenzyme A

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.17 propionate-CoA ligase

Inhibitors

Inhibitors on EC 6.2.1.17 - propionate-CoA ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-nitrobenzoate
-
inhibition of propanoyl-CoA formation in solubilized mitochondria
adenosine 5'-propyl phosphate
-
strong inhibition, bi uni uni bi ping pong mechanism
ATP
-
substrate inhibition at high concentrations, above 20 mM for the liver enzyme and above 10 mM for the mammary gland enzyme
Butyrate
dithiothreitol
-
5 or 10 mM
GSH
-
5 or 20 mM
MgCl2
-
above 10 mM
Octanoate
propanoate
-
inhibits acetate activation and butyrate activation
propyl-AMP
-
competitive with ATP and propionyl-AMP, mixed type inhibition with propionate, uncompetitive with CoA
salicylate
-
inhibition of propanoyl-CoA formation in solubilized mitochondria