6.2.1.12: 4-coumarate-CoA ligase
This is an abbreviated version!
For detailed information about 4-coumarate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.12
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6.2.1.12
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phenylpropanoids
-
lignin
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flavonoid
-
ammonia-lyase
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chalcone
-
ferulic
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4-hydroxylase
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p-coumaric
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xylem
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caffeic
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parsley
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populus
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cinnamate-4-hydroxylase
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sinapic
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cinnamyl
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monolignols
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crispum
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stilbene
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lignification
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petroselinum
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caffeate
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trans-cinnamate
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dihydroflavonol
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4.3.1.5
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taeda
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4-reductase
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cinnamoylated
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elicitor-treated
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glycinea
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3-o-methyltransferase
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3\'-hydroxylase
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cinnamoyl-coa
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guaiacyl
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hydroxycinnamoyl-coas
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megasperma
-
syringyl
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ccoaomt
-
adenylate-forming
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biotechnology
-
synthesis
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drug development
- 6.2.1.12
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phenylpropanoids
- lignin
- flavonoid
-
ammonia-lyase
- chalcone
-
ferulic
-
4-hydroxylase
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p-coumaric
- xylem
-
caffeic
- parsley
- populus
- cinnamate-4-hydroxylase
-
sinapic
-
cinnamyl
- monolignols
- crispum
- stilbene
-
lignification
-
petroselinum
- caffeate
- trans-cinnamate
- dihydroflavonol
-
4.3.1.5
- taeda
-
4-reductase
-
cinnamoylated
-
elicitor-treated
- glycinea
-
3-o-methyltransferase
-
3\'-hydroxylase
- cinnamoyl-coa
-
guaiacyl
-
hydroxycinnamoyl-coas
- megasperma
-
syringyl
- ccoaomt
-
adenylate-forming
- biotechnology
- synthesis
- drug development
Reaction
Synonyms
4-CL, 4-coumarate CoA ligase, 4-coumarate coenzyme A ligase, 4-coumarate/coenzyme A ligase, 4-coumarate: CoA ligase, 4-coumarate: coenzyme A ligase, 4-coumarate:CoA ligase, 4-coumarate:CoA-ligase, 4-coumarate:coenzyme A (CoA) ligase, 4-Coumarate:coenzyme A ligase, 4-coumarate:coenzyme-A ligase-1, 4-coumaroyl CoA ligase, 4-coumaroyl coenzyme A ligase, 4-coumaroyl-CoA ligase, 4-coumaroyl-CoA synthase, 4-coumaroyl:CoA ligase, 4-Coumaryl-CoA synthetase, 4CL, 4CL-A1, 4CL-A2, 4CL-B, 4CL1, 4CL10, 4CL2, 4CL3, 4CL4, 4CL5, 4CL7, Ar4CL, At4CL1, Caffeolyl coenzyme A synthetase, caffeoyl-CoA ligase, caffeoyl-CoA synthetase, caffeoyl-coenzyme A synthetase, CarB, Clone 4CL14, Clone 4CL16, coumarate:CoA ligase, Feruloyl CoA ligase, Feruloyl coenzyme A synthetase, Hc4CL, Hydroxy-cinnamate:CoA ligase, Hydroxycinnamate:CoA ligase, Hydroxycinnamoyl CoA synthetase, LJ4CL1, OB4CL_ctg4, OS4CL, Os4Cl1, Os4Cl2, Os4Cl3, Os4Cl4, Os4Cl5, p-Coumaroyl CoA ligase, p-coumaroyl-CoA ligase, p-Coumaryl coenzyme A synthetase, p-Coumaryl-CoA ligase, p-Coumaryl-CoA synthetase, p-Hydroxycinnamic acid:CoA ligase, p-Hydroxycinnamoyl coenzyme A synthetase, Pc4CL2, Pl4CL1, Pl4CL2, Sa4CL1, Sa4CL2, Sa4CL3, Sinapoyl coenzyme A snthetase, Synthetase, p-coumaroyl coenzyme A, type I 4CL
ECTree
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Reference on EC 6.2.1.12 - 4-coumarate-CoA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Barillas, W.; Beerhues, L.
3-Hydroxybenzoate:coenzyme A ligase and 4-coumarate:coenzyme A ligase from cultured cells of Centaurium erythraea
Planta
202
112-116
1997
Centaurium erythraea
Meng, H.; Campbell, W.H.
Facile enzymic synthesis of caffeoyl CoA
Phytochemistry
44
605-608
1997
Populus sp.
-
Becker-Andre, M.; Schulze-Lefert, P.; Hahlbrock, K.
Structural comparison, modes of expression, and putative cis-acting elements of the two 4-coumarate:CoA ligase genes in potato
J. Biol. Chem.
266
8551-8559
1991
Solanum tuberosum
Zhang, X.H.; Chiang, V.L.
Molecular cloning of 4-coumarate:coenzyme A ligase in loblolly pine and the roles of this enzyme in the biosynthesis of lignin in compression wood
Plant Physiol.
113
65-74
1997
Pinus taeda
Kajita, S.; Katayama, Y.; Omori, S.
Alterations in the biosynthesis of lignin in transgenic plants with chimeric genes for 4-coumarate:coenzyme A ligase
Plant Cell Physiol.
37
957-965
1996
Nicotiana tabacum
Uhlmann, A.; Ebel, J.
Molecular cloning and expression of 4-coumarate:coenzyme A ligase, an enzyme involved in the resistance response of soybean (Glycine max L.) against pathogen attack
Plant Physiol.
102
1147-1156
1993
Glycine max
Lee, D.; Douglas, C.J.
Two divergent members of a tobacco 4-coumarate:coenzyme A ligase (4CL) gene family. cDNA structure, gene inheritance and expression, and properties of recombinant proteins
Plant Physiol.
112
193-205
1996
Nicotiana tabacum
Yazaki, K.; Tabata, M.
Isolation and characterization of two cDNAs encoding 4-coumarate:CoA ligase in Lithospermum cell culture
Plant Cell Physiol.
36
1319-1329
1995
Lithospermum erythrorhizon
Liu, Q.; Bonness, M.S.; Liu, M.; Seradge, E.; Dixon, R.A.; Mabry, T.J.
Enzymes of B-ring-deoxy flavonoid biosynthesis in elicited cell cultures of "old man" cactus (Cephalocereus senilis)
Arch. Biochem. Biophys.
321
397-404
1995
Cephalocereus senilis
Lee, D.; Ellard, M.; Wanner, L.A.; Davis, K.R.; Douglas, C.J.
The Arabidopsis thaliana 4-coumarate: CoA ligase (4CL) gene: stress and developmentally regulated expression and nucleotide sequence of its cDNA
Plant Mol. Biol.
28
871-884
1995
Arabidopsis thaliana
Voo, K.S.; Whetten, R.W.; O'Malley, D.M.; Sederoff, R.R.
4-Coumarate:coenzyme A ligase from loblolly pine xylem. Isolation characterization, and complementary DNA cloning
Plant Physiol.
108
85-97
1995
Pinus taeda
Lindl, T.; Kreuzaler, F.; Hahlbrock, K.
Synthesis of p-coumaryl coenzyme A with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max)
Biochim. Biophys. Acta
302
457-464
1973
Glycine max
Gross, G.G.; Zenk, M.H.
Isolation and properties of hydroxycinnamate:CoA ligase from lignifying tissues of Forsythia
Eur. J. Biochem.
42
453-459
1974
Forsythia suspensa
Knobloch, K.H.; Hahlbrock, K.
Isoenzymes of p-coumarate:CoA ligase from cell suspension cultures of Glycine max
Eur. J. Biochem.
52
311-320
1975
Glycine max
Rohdes, M.J.C.; Wooltorton, L.S.C.
The p-coumaryl CoA ligase of potato tubers
Phytochemistry
14
2161-2164
1975
Solanum tuberosum
-
Vance, C.P.; Nambudiri, A.M.D.; Wat, C.K.; Towers, G.H.N.
Isolation and properties of hydroxycinnamate:CoA ligase from Polyporus hispidus
Phytochemistry
14
967-969
1975
Polyporus hispidus, Polyporus hispidus UBC 513
-
Knobloch, K.H.; Hahlbrock, K.
4-Coumarate:CoA ligase from cell suspension cultures of Petroselinum hortense Hoffm.
Arch. Biochem. Biophys.
184
237-248
1977
Petroselinum crispum
Wallis, P.J.; Rhodes, M.J.C.
Multiple forms of hydroxycinnamate:CoA ligase in etiolated pea seedlings
Phytochemistry
16
1891-1894
1977
Pisum sativum
-
Knogge, W.; Beulen, C.; Weissenböck, G.
Distribution of phenylalanine ammonia-lyase and 4-coumarate:CoA ligase in oat primary leaf tissues
Z. Naturforsch. C
36
389-395
1981
Avena sativa
-
Lhderitz, T.; Schatz, G.; Grisebach, H.
Enzymic synthesis of lignin precursors. Purification and properties of 4-coumarate:CoA ligase from cambial sap of spruce (Picia abies L.)
Eur. J. Biochem.
123
583-586
1982
Picea abies
Grand, C.; Boudet, A.; Boudet, A.M.
Isoenzymes of hydroxycinnamate:CoA ligase from poplar stems. Properties and tissue distribution
Planta
158
225-229
1983
Populus x canadensis
Kutsuki, H.; Shimada, M.; Higuchi, T.
Distribution and roles of p-hydroxycinnamate:CoA ligase in lignin biosynthesis
Phytochemistry
21
267-271
1982
Erythrina crista-galli, Metasequoia glyptostroboides, Paulownia tomentosa, Phyllostachys bambusoides, Populus x canadensis, Robinia pseudoacacia, Platycladus orientalis
-
Phan, C.T.; Letouze, R.
A comparative study of chlorophyll, phenolic and protein contents, and of hydroxycinnamate:CoA ligase activity of normal and "vitreous " plants (Prunus avium L.) obtained in vitro
Plant Sci. Lett.
31
323-327
1983
Prunus avium
-
Maule, A.J.; Ride, J.P.
Cinnamate 4-hydroxylase and hydroxacinnamate:CoA ligase in wheat leaves infected with Botrytis cinerea
Phytochemistry
22
1113-1116
1983
Triticum aestivum
-
Feutry, A.; Letouze, R.
Light-dark modulation of hydroxycinnamate:CoA ligase activity from stems of Salix babylonica cultivated in vitro
Planta
162
311-315
1984
Salix babylonica
Feutry, A.; Letouze, R.
Properties of hydroxycinnamate:CoA ligase from stems of Salix babylonica cultured in vitro
Phytochemistry
23
1557-1559
1984
Salix babylonica
-
Douglas, C.; Hoffmann, H.; Schulz, W.; Hahlbrock, K.
Structure and elicitor or u.v.light -stimulated expression of two 4-coumarate:CoA ligase genes in parsley
EMBO J.
6
1189-1195
1987
Petroselinum crispum
Gross, G.G.; Stöckigt, J.; Mansell, R.L.; Zenk, M.H.
Three novel enzymes involved in the reduction of ferulic acid to coniferyl alcohol in higher plants: ferulate:CoA Ligase, feruloyl-CoA reductase and coniferyl alcohol oxidoreductase
FEBS Lett.
31
283-286
1973
Forsythia sp.
-
Lindermayr, C.; Mollers, B.; Fliegmann, J.; Uhlmann, A.; Lottspeich, F.; Meimberg, H.; Ebel, J.
Divergent members of a soybean (Glycine max L.) 4-coumarate:coenzyme A ligase gene family
Eur. J. Biochem.
269
1304-1315
2002
Glycine max (P31687), Glycine max (Q8S564), Glycine max (Q8S5C1), Glycine max (Q8S5C2), Glycine max
Stuible, H.; Buttner, D.; Ehlting, J.; Hahlbrock, K.; Kombrink, E.
Mutational analysis of 4-coumarate:CoA ligase identifies functionally important amino acids and verifies its close relationship to other adenylate-forming enzymes
FEBS Lett.
467
117-122
2000
Arabidopsis thaliana
Stuible, H.P.; Kombrink, E.
Identification of the substrate specificity-conferring amino acid residues of 4-coumarate:coenzyme A ligase allows the rational design of mutant enzymes with new catalytic properties
J. Biol. Chem.
276
26893-26897
2001
Arabidopsis thaliana (Q9S725), Arabidopsis thaliana
Lindermayr, C.; Fliegmann, J.; Ebel, J.
Deletion of a single amino acid residue from different 4-coumarate:CoA ligases from soybean results in the generation of new substrate specificities
J. Biol. Chem.
278
2781-2786
2003
Glycine max
Heath, R.; McInnes, R.; Lidgett, A.; Huxley, H.; Lynch, D.; Jones, E.; Mahoney, N.; Spangenberg, G.
Isolation and characterisation of three 4-coumarate: CoA-ligase homologue cDNAs from perennial ryegrass (Lolium perenne)
J. Plant Physiol.
159
773-779
2002
Lolium perenne
-
Ehlting, J.; Buttner, D.; Wang, Q.; Douglas, C.J.; Somssich, I.E.; Kombrink, E.
Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms
Plant J.
19
9-20
1999
Arabidopsis thaliana (Q42524), Arabidopsis thaliana (Q9S725), Arabidopsis thaliana
Ehlting, J.; Shin, J.J.; Douglas, C.J.
Identification of 4-coumarate:coenzyme A ligase (4CL) substrate recognition domains
Plant J.
27
455-465
2001
Arabidopsis thaliana
Allina, S.M.; Pri-Hadash, A.; Theilmann, D.A.; Ellis, B.E.; Douglas, C.J.
4-Coumarate:coenzyme A ligase in hybrid poplar. Properties of native enzymes, cDNA cloning, and analysis of recombinant enzymes
Plant Physiol.
116
743-754
1998
Populus trichocarpa x Populus deltoides
Harding, S.A.; Leshkevich, J.; Chiang, V.L.; Tsai, C.J.
Differential substrate inhibition couples kinetically distinct 4-coumarate: coenzyme A ligases with spatially distinct metabolic roles in quaking aspen
Plant Physiol.
128
428-438
2002
Pinus taeda, Populus tremuloides
Pietrowska-Borek, M.; Stuible, H.P.; Kombrink, E.; Guranowski, A.
4-Coumarate:coenzyme A ligase has the catalytic capacity to synthesize and reuse various (di)adenosine polyphosphates
Plant Physiol.
131
1401-1410
2003
Arabidopsis thaliana
Schneider, K.; Hovel, K.; Witzel, K.; Hamberger, B.; Schomburg, D.; Kombrink, E.; Stuible, H.P.
The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase
Proc. Natl. Acad. Sci. USA
100
8601-8606
2003
Arabidopsis thaliana
Jiang, H.; Wood, K.V.; Morgan, J.A.
Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae
Appl. Environ. Microbiol.
71
2962-2969
2005
Arabidopsis thaliana (Q42524), Arabidopsis thaliana
Lu, H.; Zhao, Y.L.; Jiang, X.N.
Stable and specific expression of 4-coumarate:coenzyme A ligase gene (4CL1) driven by the xylem-specific Pto4CL1 promoter in the transgenic tobacco
Biotechnol. Lett.
26
1147-1152
2004
Populus tomentosa
Hamada, K.; Nishida, T.; Yamauchi, K.; Fukushima, K.; Kondo, R.; Tsutsumi, Y.
4-Coumarate:coenzyme A ligase in black locust (Robinia pseudoacacia) catalyses the conversion of sinapate to sinapoyl-CoA
J. Plant Res.
117
303-310
2004
Robinia pseudoacacia
Martinez-Cuesta, M.C.; Gasson, M.J.; Narbad, A.
Heterologous expression of the plant coumarate: CoA ligase in Lactococcus lactis
Lett. Appl. Microbiol.
40
44-49
2005
Arabidopsis thaliana
Beekwilder, J.; Wolswinkel, R.; Jonker, H.; Hall, R.; de Vos, C.H.; Bovy, A.
Production of resveratrol in recombinant microorganisms
Appl. Environ. Microbiol.
72
5670-5672
2006
Nicotiana tabacum (O24146), Nicotiana tabacum
Soltani, B.M.; Ehlting, J.; Douglas, C.J.
Genetic analysis and epigenetic silencing of At4CL1 and At4CL2 expression in transgenic Arabidopsis
Biotechnol. J.
1
1124-1136
2006
Arabidopsis thaliana
Lee, Y.; Jeon, Y.; Lee, J.S.; Kim, B.; Lee, C.H.; Ahn, J.
Enzymatic synthesis of phenolic CoAs using 4-coumarate:coenzyme A ligase (4CL) from rice
Bull. Korean Chem. Soc.
28
365-366
2007
Oryza sativa (Q6ETN3)
-
Chen, J.Y.; Wen, P.F.; Kong, W.F.; Pan, Q.H.; Wan, S.B.; Huang, W.D.
Changes and subcellular localizations of the enzymes involved in phenylpropanoid metabolism during grape berry development
J. Plant Physiol.
163
115-127
2006
Vitis vinifera
Chemler, J.A.; Yan, Y.; Leonard, E.; Koffas, M.A.
Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms
Org. Lett.
9
1855-1858
2007
Saccharomyces cerevisiae
Yun, M.S.; Chen, W.; Deng, F.; Kiyokawa, T.; Mametsuka, K.; Yogo, Y.
An in vitro screening assay to discover novel inhibitors of 4-coumarate:CoA ligase
Pest Manag. Sci.
62
1065-1071
2006
Nicotiana tabacum
Yun, M.S.; Chen, W.; Deng, F.; Yogo, Y.
Propanil and swep inhibit 4-coumarate:CoA ligase activity in vitro
Pest Manag. Sci.
63
815-820
2007
Nicotiana tabacum
Sanchez, J.P.; Ullman, C.; Moore, M.; Choo, Y.; Chua, N.
Regulation of Arabidopsis thaliana 4-coumarate:coenzyme-A ligase-1 expression by artificial zinc finger chimeras
Plant Biotechnol. J.
4
103-114
2006
Arabidopsis thaliana
Soltani, B.M.; Ehlting, J.; Hamberger, B.; Douglas, C.J.
Multiple cis-regulatory elements regulate distinct and complex patterns of developmental and wound-induced expression of Arabidopsis thaliana 4CL gene family members
Planta
224
1239-1240
2006
Arabidopsis thaliana
Chakraborty, M.; Karun, A.; Mitra, A.
Accumulation of phenylpropanoid derivatives in chitosan-induced cell suspension culture of Cocos nucifera
J. Plant Physiol.
166
63-71
2008
Cocos nucifera
Khatab, I.A.; Ishiyama, H.; Inomata, N.; Wang, X.; Szmidt, A.E.
Phylogeography of Eurasian Larix species inferred from nucleotide variation in two nuclear genes
Genes Genet. Syst.
83
55-66
2008
Larix cajanderi (B2KY80), Larix cajanderi (B2KY81), Larix cajanderi (B2KY86), Larix gmelinii (B2KY87), Larix gmelinii (B2KY89), Larix gmelinii (B2KY91), Larix gmelinii (B2KY96), Larix gmelinii (B2KYA2), Larix gmelinii, Larix kamtschatica (B2KY93), Larix kamtschatica (B2KY95), Larix kaempferi (B2KYA4), Larix kaempferi, Larix sibirica (B2KYA6), Larix sukaczewii (B2KYB3), Larix sukaczewii (B2KYB6), Larix sukaczewii
Kienow, L.; Schneider, K.; Bartsch, M.; Stuible, H.P.; Weng, H.; Miersch, O.; Wasternack, C.; Kombrink, E.
Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana
J. Exp. Bot.
59
403-419
2008
Arabidopsis thaliana
Katsuyama, Y.; Matsuzawa, M.; Funa, N.; Horinouchi, S.
Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway
Microbiology
154
2620-2628
2008
Lithospermum erythrorhizon
Silber, M.V.; Meimberg, H.; Ebel, J.
Identification of a 4-coumarate:CoA ligase gene family in the moss, Physcomitrella patens
Phytochemistry
69
2449-2456
2008
Physcomitrium patens (B7SB99), Physcomitrium patens (B7SBA0), Physcomitrium patens (B7SBA1), Physcomitrium patens (B7SBA2), Physcomitrium patens
Zhang, J.; Turley, R.B.; Stewart, J.M.
Comparative analysis of gene expression between CMS-D8 restored plants and normal non-restoring fertile plants in cotton by differential display
Plant Cell Rep.
27
553-561
2008
Gossypium hirsutum
Endler, A.; Martens, S.; Wellmann, F.; Matern, U.
Unusually divergent 4-coumarate:CoA-ligases from Ruta graveolens L
Plant Mol. Biol.
67
335-346
2008
Ruta graveolens (B3TJI4), Ruta graveolens (B3TJI5), Ruta graveolens R-20 (B3TJI4), Ruta graveolens R-20 (B3TJI5)
Wagner, A.; Donaldson, L.; Kim, H.; Phillips, L.; Flint, H.; Steward, D.; Torr, K.; Koch, G.; Schmitt, U.; Ralph, J.
Lignin manipulations in the coniferous gymnosperm Pinus radiata
Plant Physiol.
149
370-383
2009
Pinus radiata (B8QN50), Pinus radiata
Shan, L.L.; Li, X.; Wang, P.; Cai, C.; Zhang, B.; Sun, C.D.; Zhang, W.S.; Xu, C.J.; Ferguson, I.; Chen, K.S.
Characterization of cDNAs associated with lignification and their expression profiles in loquat fruit with different lignin accumulation
Planta
227
1243-1254
2008
Rhaphiolepis bibas (B3FES3), Rhaphiolepis bibas
Kang, K.; Park, M.; Park, S.; Kim, Y.S.; Lee, S.; Lee, S.G.; Back, K.
Production of plant-specific tyramine derivatives by dual expression of tyramine N-hydroxycinnamoyltransferase and 4-coumarate:coenzyme A ligase in Escherichia coli
Biotechnol. Lett.
31
1469-1475
2009
Arabidopsis thaliana
Rani, A.; Singh, K.; Sood, P.; Kumar, S.; Ahuja, P.
p-Coumarate: CoA ligase as a key gene in the yield of catechins in tea [Camellia sinensis (L.) O. Kuntze]
Funct. Integr. Genomics
9
271-275
2009
Camellia sinensis (Q3HUN0)
Cao, S.; Hu, Z.; Zheng, Y.; Lu, B.
Effect of BTH on anthocyanin content and activities of related enzymes in Strawberry after harvest
J. Agric. Food Chem.
58
5801-5805
2010
Fragaria x ananassa
Sun, H.; Li, Y.; Feng, S.; Zou, W.; Guo, K.; Fan, C.; Si, S.; Peng, L.
Analysis of five rice 4-coumarate:coenzyme A ligase enzyme activity and stress response for potential roles in lignin and flavonoid biosynthesis in rice
Biochem. Biophys. Res. Commun.
430
1151-1156
2013
Oryza sativa (P17814), Oryza sativa (Q42982), Oryza sativa (Q67W82), Oryza sativa (Q6ETN3), Oryza sativa (Q6ZAC1), Oryza sativa
Li, Z.; Li, C.; Li, J.; Zhang, Y.
Molecular cloning and functional characterization of two divergent 4-coumarate: coenzyme a ligases from Kudzu (Pueraria lobata)
Biol. Pharm. Bull.
37
113-122
2014
Pueraria montana var. lobata (U3MJP5), Pueraria montana var. lobata (U3MNX0), Pueraria montana var. lobata
Yuan, Y.; Yu, S.; Yu, J.; Zhan, Z.; Li, M.; Liu, G.; Wang, X.; Huang, L.
Predicting the function of 4-coumarate:CoA Ligase (LJ4CL1) in Lonicera japonica
Int. J. Mol. Sci.
15
2386-2399
2014
Lonicera japonica, Lonicera japonica (L7Z3F8)
Wang, Y.; Yi, H.; Wang, M.; Yu, O.; Jez, J.M.
Structural and kinetic analysis of the unnatural fusion protein 4-coumaroyl-CoA ligase: stilbene synthase
J. Am. Chem. Soc.
133
20684-20687
2011
Arabidopsis thaliana (Q42524), Arabidopsis thaliana
Gaid, M.M.; Scharnhop, H.; Ramadan, H.; Beuerle, T.; Beerhues, L.
4-Coumarate:CoA ligase family members from elicitor-treated Sorbus aucuparia cell cultures
J. Plant Physiol.
168
944-951
2011
Sorbus aucuparia (D5LLN7), Sorbus aucuparia (D5LNB5), Sorbus aucuparia (D5LNB6), Sorbus aucuparia
Rastogi, S.; Kumar, R.; Chanotiya, C.S.; Shanker, K.; Gupta, M.M.; Nagegowda, D.A.; Shasany, A.K.
4-coumarate: CoA ligase partitions metabolites for eugenol biosynthesis
Plant Cell Physiol.
54
1238-1252
2013
Agastache rugosa (Q6PQ01), Ocimum basilicum (S4WX39), Ocimum basilicum, Ocimum tenuiflorum (T1NXG6), Ocimum tenuiflorum, Ocimum basilicum CIM SAUMYA (S4WX39), Ocimum tenuiflorum CIM AYU (T1NXG6)
Alberstein, M.; Eisenstein, M.; Abeliovich, H.
Removing allosteric feedback inhibition of tomato 4-coumarate:CoA ligase by directed evolution
Plant J.
69
57-69
2012
Solanum lycopersicum
Chowdhury, M.; Choi, B.; Cho, B.; Kim, J.; Park, S.; Natarajan, S.; Lim, H.; Bae, H.
Regulation of 4CL, encoding 4-coumarate: coenzyme a ligase, expression in kenaf under diverse stress conditions
Plant OMICS
6
254-262
2013
Hibiscus cannabinus (T1RK64)
-
Gui, J.; Shen, J.; Li, L.
Functional characterization of evolutionarily divergent 4-coumarate:coenzyme a ligases in rice
Plant Physiol.
157
574-586
2011
Oryza sativa (P17814), Oryza sativa (Q42982), Oryza sativa (Q67W82), Oryza sativa (Q6ETN3), Oryza sativa (Q6ZAC1), Oryza sativa
Hess, V.; Vitt, S.; Müller, V.
A caffeyl-coenzyme A synthetase initiates caffeate activation prior to caffeate reduction in the acetogenic bacterium Acetobacterium woodii
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Acetobacterium woodii (F1CYZ6)
Wen, S.; Wang, Y.; Luo, J.; Xia, Q.; Fan, Q.; Li, S.; Wang, Z.
Cloning and tissue expression of 4-coumarate coenzyme A ligase gene in Angelica sinensis
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2015
Angelica sinensis (A0A140IPI1)
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Liu, T.; Yao, R.; Zhao, Y.; Xu, S.; Huang, C.; Luo, J.; Kong, L.
Cloning, functional characterization and site-directed mutagenesis of 4-coumarate coenzyme A ligase (4CL) involved in coumarin biosynthesis in Peucedanum praeruptorum Dunn
Front. Plant Sci.
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2017
Peucedanum praeruptorum (A0A1L7H9I4), Peucedanum praeruptorum (A0A1L7H9K0), Peucedanum praeruptorum (A0A1L7H9K1)
Kovalitskaya, Y.; Dayanova, L.; Azarova, A.; Shestibratov, K.
RNA interference-mediated down-regulation of 4-coumarate coenzyme A ligase in Populus tremula alters lignification and plant growth
Int. J. Environ. Sci. Educ.
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Populus tremula
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Guo, H.; Yang, Y.; Xue, F.; Zhang, H.; Huang, T.; Liu, W.; Liu, H.; Zhang, F.; Yang, M.; Liu, C.; Lu, H.; Zhang, Y.; Ma, L.
Effect of flexible linker length on the activity of fusion protein 4-coumaroyl-CoA ligase-stilbene synthase
Mol. Biosyst.
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2017
Arabidopsis thaliana
Kim, Y.S.; Kim, Y.B.; Kim, Y.; Lee, M.Y.; Park, S.U.
Overexpression of cinnamate 4-hydroxylase and 4-coumaroyl CoA ligase prompted flavone accumulation in Scutellaria baicalensis hairy roots
Nat. Prod. Commun.
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2014
Scutellaria baicalensis
Gao, S.; Yu, H.N.; Xu, R.X.; Cheng, A.X.; Lou, H.X.
Cloning and functional characterization of a 4-coumarate CoA ligase from liverwort Plagiochasma appendiculatum
Phytochemistry
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2015
Plagiochasma appendiculatum (A0A0D4C3L0), Plagiochasma appendiculatum
Chen, H.Y.; Babst, B.A.; Nyamdari, B.; Hu, H.; Sykes, R.; Davis, M.F.; Harding, S.A.; Tsai, C.J.
Ectopic expression of a loblolly pine class II 4-coumarate CoA ligase alters soluble phenylpropanoid metabolism but not lignin biosynthesis in Populus
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Pinus taeda (P41636), Pinus taeda (U5MY99), Pinus taeda
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Divergent and overlapping function of five 4-coumarate/coenzyme A ligases from Populus tomentosa
Plant Mol. Biol. Rep.
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2015
Populus tomentosa (H9AZ21), Populus tomentosa (H9AZ22), Populus tomentosa (H9AZ23), Populus tomentosa (H9AZ24), Populus tomentosa (Q941M3)
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Li, Y.; Kim, J.I.; Pysh, L.; Chapple, C.
Four isoforms of Arabidopsis 4-coumarate CoA ligase have overlapping yet distinct roles in phenylpropanoid metabolism
Plant Physiol.
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Arabidopsis thaliana (Q42524), Arabidopsis thaliana (Q9LU36), Arabidopsis thaliana (Q9S725), Arabidopsis thaliana (Q9S777)
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Structural basis for specificity and flexibility in a plant 4-coumarate CoA ligase
Structure
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2015
Nicotiana tabacum (O24146), Nicotiana tabacum
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Construction of synthetic pathways for raspberry ketone production in engineered Escherichia coli
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Arabidopsis thaliana (Q42524), Arabidopsis thaliana
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