6.1.2.2: nebramycin 5' synthase

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For detailed information about nebramycin 5' synthase, go to the full flat file.

Reaction

Synonyms

EC 2.1.3.13, EC 2.1.3.14, obramycin carbamoyltransferase, TacA, TobZ

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.2 acid-alcohol ligases (ester synthases)

                6.1.2.2 nebramycin 5' synthase

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Results	in table
59	AA Sequence
1	Cofactor
3	Metals/Ions
3	Natural Substrates/ Products (Substrates)
3	Organism
2	Pathway
6	Reaction
3	Reference
3	Substrates and Products (Substrate)
8	Synonyms
1	Systematic Name

Reaction

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Reaction on EC 6.1.2.2 - nebramycin 5' synthase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate

2 entries

kanamycin A + carbamoyl phosphate + ATP + H2O = 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate

(2) overall reaction

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O-carbamoyladenylate + kanamycin A = AMP + 6''-O-carbamoylkanamycin A

catalytic reaction mechanism, detailed overview

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O-carbamoyladenylate + tobramycin = AMP + nebramycin 5'

(1b)

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tobramycin + carbamoyl phosphate + ATP + H2O = nebramycin 5' + AMP + diphosphate + phosphate

(1) overall reaction

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carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate

(1a)

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carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate

(2a)

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