6.1.2.1: D-alanine-(R)-lactate ligase
This is an abbreviated version!
For detailed information about D-alanine-(R)-lactate ligase, go to the full flat file.
Word Map on EC 6.1.2.1
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6.1.2.1
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vancomycin
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glycopeptide
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peptidoglycan
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vancomycin-resistant
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faecium
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ligases
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aureus
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d-alanyl-d-alanine
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glycopeptide-resistant
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enterococcal
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subsite
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hydrogen-bonding
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faecalis
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teicoplanins
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omega-loop
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d-ala-d-lactate
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penicillin
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d-ala:d-ala
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resort
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vand-type
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d-alanine:d-alanine
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desulfitobacterium
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amycolatopsis
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hafniense
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teicoplanin-resistant
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mesenteroides
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leuconostoc
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d-ala2
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synthesis
- 6.1.2.1
- vancomycin
- glycopeptide
- peptidoglycan
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vancomycin-resistant
- faecium
- ligases
- aureus
- d-alanyl-d-alanine
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glycopeptide-resistant
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enterococcal
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subsite
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hydrogen-bonding
- faecalis
- teicoplanins
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omega-loop
- d-ala-d-lactate
- penicillin
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d-ala:d-ala
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resort
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vand-type
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d-alanine:d-alanine
- desulfitobacterium
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amycolatopsis
- hafniense
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teicoplanin-resistant
- mesenteroides
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leuconostoc
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d-ala2
- synthesis
Reaction
Synonyms
D-Ala-D-Lac ligase, D-Ala:D-Lac ligase, D-alanine-D-lactate ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-alanine:D-lactate ligase, D-alanyl-D-lactate ligase, depsipeptide ligase, VanA, VanB, VanD, VanD4, VanI, VRSA-9 Ddl
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Natural Substrates Products
Natural Substrates Products on EC 6.1.2.1 - D-alanine-(R)-lactate ligase
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REACTION DIAGRAM
additional information
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D-alanine:D-alanine (D-lactate) ligase (ADP) from Leuconostoc mesenteroides synthesizes the depsipeptide, D-alanyl-D-lactate, in addition to D-alanyl-D-alanine, when D-alanine and D-lactate are incubated simultaneously. Structure of bound D-alanine and D-lactate at the active subsites and substrate orientations, overview. With D-lactate a bifurcated H-bond from Arg301 to the R-OH of D-lactate may account for its orientation and nucleophile activation. This orientation is observed when the guanidino side chain of this residue is flexible. D-Alanine adopts an orientation that utilizes H-bonding to water 2882 and the D-alanyl phosphate in subsite 1. Both of these orientations provide mechanisms of deprotonation and place the nucleophile within 3.2 A of the electrophilic carbonyl of the D-alanyl phosphate intermediate for formation of the transition state, molecular docking and chiral specificity of lactate and alanine dockings, detailed overview
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D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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D-alanine + (R)-lactate + ATP
D-alanyl-(R)-lactate + ADP + phosphate
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