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6.1.2.1: D-alanine-(R)-lactate ligase

This is an abbreviated version!
For detailed information about D-alanine-(R)-lactate ligase, go to the full flat file.

Word Map on EC 6.1.2.1

Reaction

D-alanine
+
(R)-lactate
+
ATP
=
D-alanyl-(R)-lactate
+
ADP
+
phosphate

Synonyms

D-Ala-D-Lac ligase, D-Ala:D-Lac ligase, D-alanine-D-lactate ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-alanine:D-lactate ligase, D-alanyl-D-lactate ligase, depsipeptide ligase, VanA, VanB, VanD, VanD4, VanI, VRSA-9 Ddl

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.2 acid-alcohol ligases (ester synthases)
                6.1.2.1 D-alanine-(R)-lactate ligase

Inhibitors

Inhibitors on EC 6.1.2.1 - D-alanine-(R)-lactate ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate
-
75% inhibition at 0.5 mM
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl phenyl hydrogen phosphate
-
65% inhibition at 0.5 mM
1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate
-
83% inhibition at 0.5 mM
D-alanine
-
substrate inhibition
Oxacillin
-
VRSA-9 Ddl is less sensitive than VRSA-6 Ddl
Vancomycin