6.1.1.9: valine-tRNA ligase
This is an abbreviated version!
For detailed information about valine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.9
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6.1.1.9
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synthetases
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aminoacylation
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aminoacyl-trna
-
valylation
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isoleucyl-trna
-
anticodon
-
ilers
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turnip
-
noncognate
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leucyl-trna
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mischarged
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trna-like
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isoleucyl
-
misacylated
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misactivated
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post-transfer
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l-shaped
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aarss
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phenylalanyl-trna
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threonylation
-
trnaile
-
cysrs
-
atp-ppi
-
medicine
- 6.1.1.9
- synthetases
- aminoacylation
- aminoacyl-trna
-
valylation
-
isoleucyl-trna
-
anticodon
- ilers
-
turnip
-
noncognate
- leucyl-trna
-
mischarged
-
trna-like
-
isoleucyl
-
misacylated
-
misactivated
-
post-transfer
-
l-shaped
-
aarss
- phenylalanyl-trna
-
threonylation
- trnaile
- cysrs
-
atp-ppi
- medicine
Reaction
Synonyms
G7a, glp-4, mitochondrial valyl tRNA synthetase, More, MTTV, Os03g0694900, OsValRS2, Synthetase, valyl-transfer ribonucleate, Val-tRNA synthetase, Valine transfer ribonucleate ligase, Valine translase, Valine--tRNA ligase, ValRS, ValRS1, ValRS2, valS, valyl aminoacyl tRNA synthetase, Valyl transfer ribonucleic acid synthetase, Valyl-transfer ribonucleate synthetase, Valyl-transfer RNA synthetase, Valyl-tRNA ligase, Valyl-tRNA synthetase, valyl-tRNAsynthetase, VARS, VARS-2, Vas1, Vas2, white panicle1
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Reference on EC 6.1.1.9 - valine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bhanot, O.S.; Kucan, Z.; Aoyagi, S.; Lee, F.C.; Chambers, R.W.
Purification of tyrosine:tRNA ligase, valine:tRNA ligase, alanine:tRNA ligase, and isoleucine:tRNA ligase from Saccharomyces cerevisiae alphaS288C
Methods Enzymol.
29E
547-576
1974
Saccharomyces cerevisiae, Saccharomyces cerevisiae alphaS288C
-
Kohda, D.; Yokoyama, S; Miyazawa, T.
Thermostable valyl-tRNA, isoleucyl-tRNA and methionyl-tRNA synthetases from an extreme thermophile Thermus thermophilus HB8. Protein structure and Zn2+ binding
FEBS Lett.
174
20-23
1984
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Colas, B.; Imbault, P.; Sarantoglou, V.; Boulanger, Y.; Weil, J.H.
Chloroplastic and cytoplasmic valyl- and leucyl-tRNA synthetases from Euglena gracilis. Comparative study of their structural properties
Biochim. Biophys. Acta
697
71-77
1982
Euglena gracilis
Imbault, P.; Sarantoglou, V.; Weil, J.H.
Properties of purified chloroplastic and cytoplasmic valyl- and leucyl-tRNA synthetases from Euglena gracilis
Phytochemistry
21
1189-1193
1982
Euglena gracilis
-
Freist, W.; von der Haar, F.; Faulhammer, H.; Cramer, F.
Valyl-tRNA, isoleucyl-tRNA and tyrosyl-tRNA synthetase from baker's yeast. Substrate specificity with regard to ATP analogs and mechanism of the aminoacylation reaction
Eur. J. Biochem.
66
493-497
1976
Saccharomyces cerevisiae
Dreher, T.W.; Tsai, C.H.; Florentz, C.; Giege, R.
Specific valylation of turnip yellow mosaic virus RNA by wheat germ valyl-tRNA synthetase determined by three anticodon loop nucleotides
Biochemistry
31
9183-9189
1992
Triticum aestivum
Hountondji, C.; Schmitter, J.M.; Fukui, T.; Tagaya, M.; Blanquet, S.
Affinity labeling of aminoacyl-tRNA synthetases with adenosine triphosphopyridoxal. Probing the Lys-Met-Ser-Lys-Ser signature sequence as the ATP-binding site in Escherichia coli methionyl- and valyl-tRNA synthetases
Biochemistry
29
11266-11273
1990
Escherichia coli
Bee, G.; Kerjan, P.; Zha, X.D.; Waller, J.P.
Valyl-tRNA synthetase from rabbit liver. Purification as a heterotypic complex in association with elongation factor 1
J. Biol. Chem.
264
21131-21137
1989
Oryctolagus cuniculus
Bee, G.; Waller, J.P.
Valyl-tRNA synthetase from rabbit liver. II. The enzyme derived from the high-Mr complex displays hydrophobic as well as polyanion-binding properties
J. Biol. Chem.
264
21138-21143
1989
Saccharomyces cerevisiae, Oryctolagus cuniculus, Saccharomyces cerevisiae D273
Godar, D.E.; Yang, D.C.H.
Mammalian high molecular weight and monomeric forms of valyl-tRNA synthetase
Biochemistry
27
2181-2186
1988
Rattus norvegicus
Bergmann, F.H.; Berg, P.; Dieckmann, M.
The Enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl-, and methionyl ribonucleic acid synthetases from Escherichia coli
J. Biol. Chem.
236
1735-1740
1961
Escherichia coli
-
Paradies, H.H.
Isolation and crystallization of valyl-tRNA synthetase from E. coli MRE 600
J. Biochem.
76
655-659
1974
Escherichia coli, Escherichia coli MRE 600
Suyama, Y.; Hamada, J.
The mitochondrial and cytoplasmic valyl tRNA synthetases in Tetrahymena are indistinguishable
Arch. Biochem. Biophys.
191
437-443
1978
Tetrahymena pyriformis
Natarajan, V.; Gopinathan, K.P.
Purification and properties of valyl-tRNA synthetase from Mycobacterium smegmatis
Biochim. Biophys. Acta
568
253-263
1979
Mycolicibacterium smegmatis
Sarantoglou, V.; Imbault, P.; Weil, J.H.
The use of affinity elution from blue dextran Sepharose by yeast tRNA2Val in the complete purification of the cytoplasmic valyl-tRNA synthetase from Euglena gracilis
Biochem. Biophys. Res. Commun.
93
134-140
1980
Euglena gracilis
Felter, S.; Diatewa, M.; Schneider, C.; Stahl, A.J.C.
Yeast mitochondrial and cytoplasmic valyl-tRNA synthetases
Biochem. Biophys. Res. Commun.
98
727-734
1981
Saccharomyces cerevisiae
Jakubowski, H.
The mechanism of inhibition of valyl-tRNA synthetase by S-adenosylhomocysteine
Biochim. Biophys. Acta
709
325-331
1982
Lupinus luteus
Black, S.
A novel thiol-dependent arsenite-sensitive valyl-tRNA synthetase activity from yeast
J. Biol. Chem.
258
2112-2114
1983
Saccharomyces cerevisiae
Black, S.
Inhibition of the reductive activation of a valyl-tRNA synthetase from yeast by unsaturated fatty acids and associated observations on newly found lipophilic substances from yeast
J. Biol. Chem.
260
433-440
1985
Saccharomyces cerevisiae
Brand, N.J.; Fersht, A.R.
Molecular cloning of the gene encoding the valyl-tRNA synthetase from Bacillus stearothermophilus
Gene
44
139-142
1986
Geobacillus stearothermophilus
Kakitani, M.; Tonomura, B.; Hiromi, K.
Valyl-tRNA synthetase from Bacillus stearothermophilus. Purification and binding with the substrates L-valine and ATP
Agric. Biol. Chem.
50
2437-2444
1986
Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503
-
Motorin, Y.A.; Wolfson, A.D.; Orlowsky, A.F.; Gladilin, K.L.
Purification of valyl-tRNA synthetase high-molecular-mass complex from rabbit liver
FEBS Lett.
220
363-365
1987
Oryctolagus cuniculus
Härtlein, M.; Frank, R.; Madern, D.
Nucleotide sequence of Escherichia coli valyl-tRNA synthetase gene valS
Nucleic Acids Res.
15
9081-9082
1987
Escherichia coli
Heck, J.D.; Hatfield, G.W.
Valyl-tRNA synthetase gene of Escherichia coli K12. Primary structure and homology within a family of aminoacyl-tRNA synthetases
J. Biol. Chem.
263
868-877
1988
Escherichia coli
Tardif, K.D.; Liu, M.; Vitseva, O.; Hou, Y.M.; Horowitz, J.
Misacylation and editing by Escherichia coli valyl-tRNA synthetase: evidence for two tRNA binding sites
Biochemistry
40
8118-8125
2001
Escherichia coli
Hountondji, C.; Lazennec, C.; Beauvallet, C.; Dessen, P.; Pernollet, J.C.; Plateau, P.; Blanquet, S.
Crucial role of conserved lysine 277 in the fidelity of tRNA aminoacylation by Escherichia coli valyl-tRNA synthetase
Biochemistry
41
14856-14865
2002
Escherichia coli
Fukai, S.; Nureki, O.; Sekine, S.; Shimada, A.; Tao, J.; Vassylyev, D.G.; Yokoyama, S.
Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase
Cell
103
793-803
2000
Thermus thermophilus
Ramesh, V.; RajBhandary, U.L.
Importance of the anticodon sequence in the aminoacylation of tRNAs by methionyl-tRNA synthetase and by valyl-tRNA synthetase in an archaebacterium
J. Biol. Chem.
276
3660-3665
2001
Haloferax volcanii, Haloferax volcanii WFD11
Tardif, K.D.; Horowitz, J.
Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase
Nucleic Acids Res.
30
2538-2545
2002
Escherichia coli
Tardif, K.D.; Horowitz, J.
Functional group recognition at the aminoacylation and editing sites of E. coli valyl-tRNA synthetase
RNA
10
493-503
2004
Escherichia coli
Fukai, S.; Nureki, O.; Sekine, S.; Shimada, A.; Vassylyev, D.G.; Yokoyama, S.
Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA
9
100-111
2003
Thermus thermophilus
Jiang, S.; Wolfe, C.L.; Warrington, J.A.; Norcum, M.T.
Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit
FEBS Lett.
579
6049-6054
2005
Homo sapiens
Fukunaga, R.; Yokoyama, S.
Structural basis for non-cognate amino acid discrimination by the valyl-tRNA synthetase editing domain
J. Biol. Chem.
280
29937-29945
2005
Thermus thermophilus (P96142), Thermus thermophilus
Massey, S.E.
Basic faced alpha-helices are widespread in the peptide extensions of the eukaryotic aminoacyl-tRNA synthetases
In Silico Biol.
6
259-273
2006
Saccharomyces cerevisiae, Homo sapiens (P26640), Takifugu rubripes (P49696), Arabidopsis thaliana (P93736), Oryza sativa (Q851K9)
Chang, K.J.; Lin, G.; Men, L.C.; Wang, C.C.
Redundancy of non-AUG initiators. A clever mechanism to enhance the efficiency of translation in yeast
J. Biol. Chem.
281
7775-7783
2006
Saccharomyces cerevisiae
Chang, C.P.; Lin, G.; Chen, S.J.; Chiu, W.C.; Chen, W.H.; Wang, C.C.
Promoting the formation of an active synthetase/tRNA complex by a nonspecific tRNA-binding domain
J. Biol. Chem.
283
30699-30706
2008
Saccharomyces cerevisiae, Homo sapiens
Rorbach, J.; Yusoff, A.A.; Tuppen, H.; Abg-Kamaludin, D.P.; Chrzanowska-Lightowlers, Z.M.; Taylor, R.W.; Turnbull, D.M.; McFarland, R.; Lightowlers, R.N.
Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutation
Nucleic Acids Res.
36
3065-3074
2008
Homo sapiens
Bharatham, N.; Bharatham, K.; Lee, Y.; Woo Lee, K.
Molecular dynamics simulation study of valyl-tRNA synthetase with its pre- and post-transfer editing substrates
Biophys. Chem.
143
34-43
2009
Thermus thermophilus (P96142)
Chiu, W.C.; Chang, C.P.; Wen, W.L.; Wang, S.W.; Wang, C.C.
Schizosaccharomyces pombe possesses two paralogous valyl-tRNA synthetase genes of mitochondrial origin
Mol. Biol. Evol.
27
1415-1424
2010
Schizosaccharomyces pombe (O14160), Schizosaccharomyces pombe (O75005), Schizosaccharomyces pombe
Montanari, A.; De Luca, C.; Frontali, L.; Francisci, S.
Aminoacyl-tRNA synthetases are multivalent suppressors of defects due to human equivalent mutations in yeast mt tRNA genes
Biochim. Biophys. Acta
1803
1050-1057
2010
Homo sapiens
Dulic, M.; Cvetesic, N.; Perona, J.J.; Gruic-Sovulj, I.
Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases
J. Biol. Chem.
285
23799-23809
2010
Escherichia coli
Li, L.; Yu, L.; Huang, Q.
Molecular trigger for pre-transfer editing pathway in valyl-tRNA synthetase: a molecular dynamics simulation study
J. Mol. Model.
17
555-564
2011
Thermus thermophilus (P96142)
Duarte, M.; Videira, A.
Defective valyl-tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa
Biochem. J.
448
297-306
2012
Neurospora crassa
Olmedo-Verd, E.; Santamaria-Gomez, J.; Ochoa de Alda, J.A.; Ribas de Pouplana, L.; Luque, I.
Membrane anchoring of aminoacyl-tRNA synthetases by convergent acquisition of a novel protein domain
J. Biol. Chem.
286
41057-41068
2011
Anabaena sp., Anabaena sp. PCC 7120
Cvetesic, N.; Perona, J.J.; Gruic-Sovulj, I.
Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic steps
J. Biol. Chem.
287
25381-25394
2012
Escherichia coli
Starosta, A.L.; Lassak, J.; Peil, L.; Atkinson, G.C.; Woolstenhulme, C.J.; Virumaee, K.; Buskirk, A.; Tenson, T.; Remme, J.; Jung, K.; Wilson, D.N.
A conserved proline triplet in Val-tRNA synthetase and the origin of elongation factor P
Cell Rep.
9
476-483
2014
Escherichia coli (P07118)
Santamaria-Gomez, J.; Ochoa de Alda, J.A.; Olmedo-Verd, E.; Bru-Martinez, R.; Luque, I.
Sub-cellular localization and complex formation by aminoacyl-tRNA synthetases in cyanobacteria evidence for interaction of membrane-anchored ValRS with ATP synthase
Front. Microbiol.
7
857
2016
Nostoc sp. PCC 7120 = FACHB-418 (Q8YX97)
Rastogi, S.; Borgo, B.; Pazdernik, N.; Fox, P.; Mardis, E.; Kohara, Y.; Havranek, J.; Schedl, T.
Caenorhabditis elegans glp-4 encodes a valyl aminoacyl tRNA synthetase
G3 (Bethesda)
5
2719-2728
2015
Caenorhabditis elegans (Q9U1Q4), Caenorhabditis elegans
Wang, Y.; Wang, C.; Zheng, M.; Lyu, J.; Xu, Y.; Li, X.; Niu, M.; Long, W.; Wang, D.; Wang, H.; Terzaghi, W.; Wang, Y.; Wan, J.
White panicle1, a Val-tRNA synthetase regulating chloroplast ribosome biogenesis in rice, is essential for early chloroplast development
Plant Physiol.
170
2110-2123
2016
Oryza sativa Japonica Group (Q851K9)
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