6.1.1.7: alanine-tRNA ligase

This is an abbreviated version!
For detailed information about alanine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

AARS2, Ala-tRNA synthetase, ALA1, ALA2, Alanine transfer RNA synthetase, Alanine translase, Alanine tRNA synthetase, Alanine--tRNA ligase, Alanine-transfer RNA ligase, alanine-tRNA ligase, alanyl tRNA ligase, Alanyl-transfer ribonucleate synthetase, Alanyl-transfer ribonucleic acid synthetase, Alanyl-transfer RNA synthetase, alanyl-tRNA ligase, alanyl-tRNA synthase, Alanyl-tRNA synthetase, alanyltRNA synthetase, AlaRS, mitochondrial alanyl-tRNA synthetase, More, mtAlaRS, MurM, MurN, Synthase, alanyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.7 alanine-tRNA ligase

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Results	in table
6	Activating Compound
56313	AA Sequence
2	Application
1	CAS Registry Number
29	Cloned(Commentary)
18	Cofactor
9	Crystallization (Commentary)
151	Disease/ Diagnostics
4	Expression
18	General Information
2	General Stability
16	Inhibitors
1	kcat/KM [mM/s]
2	Ki Value [mM]
57	KM Value [mM]
24	Localization
17	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
159	Organism
4	Pathway
70	PDB ID
14	pH Optimum
1	pH Range
51	Protein Variants
24	Purification (Commentary)
2	Reaction
20	Reaction Type
61	Reference
2	Renatured (Commentary)
8	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
79	Substrates and Products (Substrate)
21	Subunits
176	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]
38	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 6.1.1.7 - alanine-tRNA ligase

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10 - 37

Escherichia coli

-

independent of temperature in this range

512

25 - 75

Thermus thermophilus

-

half-maximal activity at 25°C and 75°C with substrate tRNAAla, a sharp 345fold drop of activity occurs at 70°C, temperature profile

651165

35 - 65

Thermus thermophilus

-

half-maximal activity at 35°C and 65°C with substrate tmRNA, a sharp 345fold drop of activity occurs at 40°C, temperature profile

651165