6.1.1.7: alanine-tRNA ligase

This is an abbreviated version!
For detailed information about alanine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

AARS2, Ala-tRNA synthetase, ALA1, ALA2, Alanine transfer RNA synthetase, Alanine translase, Alanine tRNA synthetase, Alanine--tRNA ligase, Alanine-transfer RNA ligase, alanine-tRNA ligase, alanyl tRNA ligase, Alanyl-transfer ribonucleate synthetase, Alanyl-transfer ribonucleic acid synthetase, Alanyl-transfer RNA synthetase, alanyl-tRNA ligase, alanyl-tRNA synthase, Alanyl-tRNA synthetase, alanyltRNA synthetase, AlaRS, mitochondrial alanyl-tRNA synthetase, More, mtAlaRS, MurM, MurN, Synthase, alanyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.7 alanine-tRNA ligase

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Results	in table
6	Activating Compound
56313	AA Sequence
2	Application
1	CAS Registry Number
29	Cloned(Commentary)
18	Cofactor
9	Crystallization (Commentary)
151	Disease/ Diagnostics
4	Expression
18	General Information
2	General Stability
16	Inhibitors
1	kcat/KM [mM/s]
2	Ki Value [mM]
57	KM Value [mM]
24	Localization
17	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
159	Organism
4	Pathway
70	PDB ID
14	pH Optimum
1	pH Range
51	Protein Variants
24	Purification (Commentary)
2	Reaction
20	Reaction Type
61	Reference
2	Renatured (Commentary)
8	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
79	Substrates and Products (Substrate)
21	Subunits
176	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]
38	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 6.1.1.7 - alanine-tRNA ligase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-mercaptoethanol

Sus scrofa

-

-

517

2-mercaptoethylamine

Sus scrofa

-

-

517

5'-O-[N-(L-alanyl)-sulfamoyl]adenosine

Escherichia coli

-

-

726973

5'-O-[N-(L-glycinyl)sulfamoyl]-adenosine

Escherichia coli

-

-

726973

5,5'-dithiobis(2-nitrobenzoate)

2 entries

elongation factor Tu

Thermus thermophilus

-

strongly inhibits the aminoacylation of tmRNA, deviation from the mechanism of aminoacyl ester bond protection upon formation of the canonical ternary complx between the elongation gactor Tu, nucleotide cofactor and aminoacyl-tRNA

651165

-

guanidine hydrochloride

Escherichia coli

-

at 0.8 M guanidine hydrochloride, the enzyme forms a molten globule like intermediate, which is enzymatically inactive

728753

L-cysteine

Sus scrofa

-

-

517

L-glutathione

Sus scrofa

-

-

517

monobromobimane

Escherichia coli

-

-

515

NEM

Escherichia coli

-

-

524

p-Hydroxymercuriphenylsulfonic acid

Escherichia coli

-

-

515

p-Substituted mercuribenzoate

Sus scrofa

-

-

517

sulfhydryl group containing substances

Sus scrofa

-

-

517

Urea

Escherichia coli

-

denaturation at 3.3 M, the Zn2+-depleted enzyme is much more sensitive to denaturation by urea than the native enzyme

649422

5,5'-dithiobis(2-nitrobenzoate)

Escherichia coli

-

-

515

5,5'-dithiobis(2-nitrobenzoate)

Escherichia coli

-

reversed by DTT

524