6.1.1.23: aspartate-tRNAAsn ligase

This is an abbreviated version!
For detailed information about aspartate-tRNAAsn ligase, go to the full flat file.

Reaction

Synonyms

aspartate tRNA synthetase, Aspartic acid translase, Aspartyl ribonucleic synthetase, aspartyl tRNA synthetase, aspartyl-transfer ribonucleate synthetase, Aspartyl-transfer ribonucleic acid synthetase, Aspartyl-transfer RNA synthetase, Aspartyl-tRNA synthetase, AspRS, EC 6.1.1.12, More, ND-AspRS, non-discriminating aspartyl-tRNA synthetase, nondicriminating AspRS, nondiscriminating aspartyl-tRNA synthetase, nondiscriminating AspRS, Synthetase, aspartyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.23 aspartate-tRNAAsn ligase

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Results	in table
1	Activating Compound
27069	AA Sequence
1	CAS Registry Number
25	Cloned(Commentary)
14	Cofactor
7	Crystallization (Commentary)
2	Disease/ Diagnostics
1	General Information
1	General Stability
2	Inhibitors
9	kcat/KM [mM/s]
3	Ki Value [mM]
33	KM Value [mM]
4	Localization
9	Metals/Ions
6	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
43	Organism
5	Pathway
10	PDB ID
6	pH Optimum
1	Posttranslational Modification
28	Protein Variants
13	Purification (Commentary)
4	Reaction
3	Reaction Type
38	Reference
3	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
80	Substrates and Products (Substrate)
8	Subunits
65	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
27	Turnover Number [1/s]

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Turnover Number on EC 6.1.1.23 - aspartate-tRNAAsn ligase

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.012 - 0.6

tRNAAsn

13 entries

0.021 - 7.2

tRNAAsp

13 entries

additional information

additional information

Helicobacter pylori

-

the wild-type enzyme has a kcat for tRNAAsp that is 60% higher than that of tRNAAsn

672190

-

0.012

tRNAAsn

Halalkalibacterium halodurans

Q9KDG1

at pH 8.0 and 37°C

745554

0.014

tRNAAsn

Helicobacter pylori

-

pH 7.5, recombinant wild-type enzyme

672190

0.015

tRNAAsn

Helicobacter pylori

-

pH 7.5, recombinant mutant L86M enzyme

672190

0.026

tRNAAsn

Helicobacter pylori

-

pH 7.5, recombinant mutant L81N enzyme

672190

0.058

tRNAAsn

Bacillus subtilis

O32038

at pH 7.2 and 37°C

745554

0.092

tRNAAsn

Thermus thermophilus

-

AspRS2

440089

0.111

tRNAAsn

Pseudomonas aeruginosa

-

at pH 7.2 and 37°C

746304

0.17

tRNAAsn

Bdellovibrio bacteriovorus

Q6MI59

at pH 7.2 and 37°C

746252

0.2

tRNAAsn

Staphylococcus aureus

-

at pH 7.2 and 37°C

744899

0.22

tRNAAsn

Deinococcus radiodurans

-

37°C, pH 7.0, mutant enzyme H28Q

659475

0.22

tRNAAsn

Deinococcus radiodurans

-

37°C, pH 7.0, mutant enzyme P77K/H28Q

659475

0.51

tRNAAsn

Deinococcus radiodurans

-

37°C, pH 7.0, wild-type enzym

659475

0.6

tRNAAsn

Deinococcus radiodurans

-

37°C, pH 7.0, mutant enzyme P77K

659475

0.021

tRNAAsp

Helicobacter pylori

-

pH 7.5, recombinant mutant L86M enzyme

672190

0.022

tRNAAsp

Helicobacter pylori

-

pH 7.5, recombinant wild-type enzyme

672190

0.028

tRNAAsp

Helicobacter pylori

-

pH 7.5, recombinant mutant L81N enzyme

672190

0.115

tRNAAsp

Halalkalibacterium halodurans

Q9KDG1

at pH 8.0 and 37°C

745554

0.14

tRNAAsp

Deinococcus radiodurans

-

37°C, pH 7.0, mutant enzyme P77K/H28Q

659475

0.15

tRNAAsp

Deinococcus radiodurans

-

37°C, pH 7.0, wild-type enzyme

659475

0.17

tRNAAsp

Deinococcus radiodurans

-

37°C, pH 7.0, mutant enzyme H28Q

659475

0.24

tRNAAsp

Thermus thermophilus

-

AspRS2

440089

0.24

tRNAAsp

Staphylococcus aureus

-

at pH 7.2 and 37°C

744899

0.28

tRNAAsp

Deinococcus radiodurans

-

37°C, pH 7.0, mutant enzyme P77K

659475

0.36

tRNAAsp

Bacillus subtilis

O32038

at pH 7.2 and 37°C

745554

0.52

tRNAAsp

Bdellovibrio bacteriovorus

Q6MI59

at pH 7.2 and 37°C

746252

7.2

tRNAAsp

Thermus thermophilus

-

AspRS1

440089