6.1.1.23: aspartate-tRNAAsn ligase

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For detailed information about aspartate-tRNAAsn ligase, go to the full flat file.

Reaction

Synonyms

aspartate tRNA synthetase, Aspartic acid translase, Aspartyl ribonucleic synthetase, aspartyl tRNA synthetase, aspartyl-transfer ribonucleate synthetase, Aspartyl-transfer ribonucleic acid synthetase, Aspartyl-transfer RNA synthetase, Aspartyl-tRNA synthetase, AspRS, EC 6.1.1.12, More, ND-AspRS, non-discriminating aspartyl-tRNA synthetase, nondicriminating AspRS, nondiscriminating aspartyl-tRNA synthetase, nondiscriminating AspRS, Synthetase, aspartyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.23 aspartate-tRNAAsn ligase

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Results	in table
1	Activating Compound
27069	AA Sequence
1	CAS Registry Number
25	Cloned(Commentary)
14	Cofactor
7	Crystallization (Commentary)
2	Disease/ Diagnostics
1	General Information
1	General Stability
2	Inhibitors
9	kcat/KM [mM/s]
3	Ki Value [mM]
33	KM Value [mM]
4	Localization
9	Metals/Ions
6	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
43	Organism
5	Pathway
10	PDB ID
6	pH Optimum
1	Posttranslational Modification
28	Protein Variants
13	Purification (Commentary)
4	Reaction
3	Reaction Type
38	Reference
3	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
80	Substrates and Products (Substrate)
8	Subunits
65	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
27	Turnover Number [1/s]

General Information

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General Information on EC 6.1.1.23 - aspartate-tRNAAsn ligase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Thermus thermophilus

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during tRNA-dependent asparagine formation, tRNAAsn promotes assembly of a ribonucleoprotein particle called transamidosome that allows channelling of the aa-tRNA from non-discriminating aspartyl-tRNA synthetase active site to the GatCAB amidotransferase site. A transamidosome particle is formed by two GatCABs, two dimeric nondiscriminating-AspRSs and four tRNAsAsn molecules. In the complex, only two tRNAs are bound in a functional state, whereas the two other ones act as an RNA scaffold enabling release of the asparaginyl-tRNAAsn without dissociation of the complex. The transamidosome constitutes a transfer-ribonucleoprotein particle in which tRNAs serve the function of both substrate and structural foundation for a large molecular machine

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