6.1.1.20: phenylalanine-tRNA ligase

This is an abbreviated version!
For detailed information about phenylalanine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.20

6.1.1.20

aminoacylation

synthetases

aminoacyl-trna

phenylalanylation

thermophilus

thermus

anticodon

aarss

proofreading

phe-trnaphe

noncognate

tyrosyl-trna

misacylated

seryl-trna

threonyl-trna

misaminoacylated

mischarging

trna-phe

aminoacyladenylate

valyl-trna

alphabeta2

biotechnology

Reaction

ATP

+

L-phenylalanine

+

tRNAPhe

=

AMP

+

diphosphate

+

L-phenylalanyl-tRNAPhe

Synonyms

CML33, ctPheRS, cytoplasmic phenylalanyl-tRNA synthetase, cytosolic phenylalanyl-tRNA synthetase, cytosolic PheRS, EcPheRS, FARS2, FRS, hcPheRS, HSPC173, L-Phenylalanyl-tRNA synthetase, mitochondrial phenylalanyl-tRNA synthetase, mitochondrial PheRS, mitPheRS, More, mtPheRS, p-azido-phenylalanyl-tRNA synthetase, pAzFRS, Phe-RS, Phenylalanine translase, phenylalanine tRNA synthetase, Phenylalanine--tRNA ligase, Phenylalanine-tRNA synthetase, Phenylalanyl transfer ribonucleic acid synthetase, Phenylalanyl-transfer ribonucleate synthetase, Phenylalanyl-transfer RNA ligase, Phenylalanyl-transfer RNA synthetase, Phenylalanyl-tRNA ligase, Phenylalanyl-tRNA synthetase, PheRS, PheRS-alpha, Synthetase, phenylalanyl-transfer ribonucleate

ECTree

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.20 phenylalanine-tRNA ligase

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Results	in table
4	Activating Compound
102634	AA Sequence
3	Application
1	CAS Registry Number
34	Cloned(Commentary)
61	Cofactor
19	Crystallization (Commentary)
186	Disease/ Diagnostics
4	General Information
1	General Stability
112	IC50 Value
292	Inhibitors
32	kcat/KM [mM/s]
135	Ki Value [mM]
157	KM Value [mM]
33	Localization
33	Metals/Ions
74	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
583	Organism
4	Pathway
123	PDB ID
18	pH Optimum
1	pH Range
1	pH Stability
3	pI Value
1	Posttranslational Modification
71	Protein Variants
35	Purification (Commentary)
11	Reaction
65	Reaction Type
155	Reference
36	Source Tissue
20	Specific Activity [micromol/min/mg]
2	Storage Stability
248	Substrates and Products (Substrate)
69	Subunits
490	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
3	Temperature Range [°C]
10	Temperature Stability [°C]
76	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 6.1.1.20 - phenylalanine-tRNA ligase

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0.0026 - 0.0031

(2R,3R,3aS,5aS,10aR)-N-(3,4-dichlorophenyl)-4,10-dioxo-2-phenyl-2,3,3a,4,5a,10-hexahydrofuro[2,3-c]indeno[1,2-b]furan-3-carboxamide

show

0.00047 - 0.00051

(2R,3R,3aS,5aS,10R,10aS)-N-(3,4-dichlorophenyl)-10-hydroxy-4-oxo-2-phenyl-2,3,3a,4,5a,10-hexahydrofuro[2,3-c]indeno[1,2-b]furan-3-carboxamide

show

0.00017 - 0.00026

(2R,3R,3aS,5aS,10S,10aS)-N-(3,4-dichlorophenyl)-10-hydroxy-4-oxo-2-phenyl-2,3,3a,4,5a,10-hexahydrofuro[2,3-c]indeno[1,2-b]furan-3-carboxamide

show

0.00017 - 0.002

(2Z)-2-(cyclopropylimino)-3-(2-thienylmethyl)-1,3-thiazolidin-4-one

show

0.00001 - 0.0006

(2Z)-2-[(3-chlorophenyl)imino]-3-(2-thienylmethyl)-1,3-thiazolidin-4-one

show

0.00004

(3a'R,6a'S)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone

show

0.00073 - 0.00099

(3a'R,6a'S)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone

show

0.003 - 0.004

(3a'S,6a'R)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone

show

0.0061 - 0.0087

(3a'S,6a'R)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone

show

0.00056 - 0.00085

(3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.00007 - 0.00022

(3aR,6aS)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.000002 - 0.000005

(3aS,6aR)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.0083 - 0.0137

(3aS,6aR)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.032 - 0.045

(3aS,6aR)-5-[4-chloro-3-(trifluoromethyl)phenyl]-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.000004 - 0.00013

(3R,3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.011 - 0.033

(3R,4S,5R)-4-[(3,4-dichlorophenyl)carbamoyl]-1',3'-dioxo-5-phenyl-1',3',4,5-tetrahydro-3H-spiro[furan-2,2'-indene]-3-carboxylic acid

show

0.00082 - 0.0032

(3S,3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

show

0.0023 - 0.0049

1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)[2,2'-binaphthalene]-8,8'-dicarbaldehyde

show

0.00011

1-(3-bromophenyl)-2-[(2-methoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 110 nM

0.000031

1-(3-chlorophenyl)-2-[(2-phenoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 31 nM

0.000032

1-(3-iodophenyl)-2-[(2-phenoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 32 nM

0.000083

1-(3-methoxyphenyl)-2-[(2-phenoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 83 nM

0.000015 - 0.00005

1-(3-[[4-(3,5-dichlorophenyl)piperazin-1-yl]sulfonyl]phenyl)-3-(1,3-thiazol-2-yl)urea

show

0.00005

1-(4-bromothiophen-2-yl)-2-[(2-methoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 50 nM

0.00012

1-(4-bromothiophen-2-yl)-2-[(2-phenoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 120 nM

0.000026

1-(4-bromothiophen-2-yl)-2-[(2-[[4-(methylsulfonyl)benzyl]oxy]benzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 26 nM

0.000008

1-(4-bromothiophen-2-yl)-2-[[2-(2-hydroxyethoxy)benzyl]amino]ethanol

Staphylococcus aureus

-

IC50: 8 nM

0.000018

1-(4-bromothiophen-2-yl)-2-[[2-(but-3-en-1-yloxy)benzyl]amino]ethanol

Staphylococcus aureus

-

IC50: 18 nM

0.000035

1-(4-bromothiophen-2-yl)-2-[[2-(methoxymethoxy)benzyl]amino]ethanol

Staphylococcus aureus

-

IC50: 35 nM

0.000043

1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-2-ylmethoxy)benzyl]amino]ethanol

Staphylococcus aureus

-

IC50: 43 nM

0.000018

1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-3-ylmethoxy)benzyl]amino]ethanol

Staphylococcus aureus

-

IC50: 18 nM

0.000016

1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-4-ylmethoxy)benzyl]amino]ethanol

Staphylococcus aureus

-

IC50: 16 nM

0.00057

1-[3-(hydroxymethyl)phenyl]-2-[(2-phenoxybenzyl)amino]ethanol

Staphylococcus aureus

-

IC50: 570 nM

0.016 - 0.2

2-(3-methoxyphenyl)-5-(trifluoromethyl)-1H-imidazole

show

0.00011

2-[(2-methoxybenzyl)amino]-1-(3-methylphenyl)ethanol

Staphylococcus aureus

-

IC50: 110 nM

0.00019

2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)phenyl]ethanol

Staphylococcus aureus

-

IC50: 190 nM

0.00016

2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol

Staphylococcus aureus

-

IC50: 160 nM

0.00079

2-[(2-methylbenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol

Staphylococcus aureus

-

IC50: 790 nM

0.00019 - 0.026

2-[(4-chlorophenoxy)methyl]-N-(2-sulfamoylethyl)-1,3-thiazole-4-carboxamide

show

0.0001 - 0.013

2-[(4-chlorophenoxy)methyl]-N-(cyanomethyl)-1,3-thiazole-4-carboxamide

show

0.0025

2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]benzoic acid

Staphylococcus aureus

-

IC50: 2500 nM

0.0001

2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]phenol

Staphylococcus aureus

-

IC50: 100 nM

0.00011

2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)acetamide

Staphylococcus aureus

-

IC50: 110 nM

0.000032

2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-ethylacetamide

Staphylococcus aureus

-

IC50: 32 nM

0.000042

2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetamide

Staphylococcus aureus

-

IC50: 42 nM

0.0001 - 0.034

2-[3-[(4-chloropyridin-2-yl)amino]phenoxy]-N-(1,1-dioxo-1l6-thiolan-3-yl)acetamide

show

0.0014 - 0.082

2-[3-[(4-chloropyridin-2-yl)amino]phenoxy]-N-methylacetamide

show

0.00056 - 0.041

2-[3-[(4-cyanopyridin-2-yl)amino]phenoxy]-N-methylacetamide

show

0.000022

2-[4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione

Staphylococcus aureus

-

IC50: 22 nM

0.000026

2-[[2-(1H-benzimidazol-2-ylmethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol

Staphylococcus aureus

-

IC50: 26 nM

0.00022

2-[[2-(2-aminoethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol

Staphylococcus aureus

-

IC50: 220 nM

0.000022

2-[[2-(4-aminobutoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol

Staphylococcus aureus

-

IC50: 22 nM

0.00001

2-[[2-(benzyloxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol

Staphylococcus aureus

-

IC50: 10 nM

0.00005

2-[[2-(benzyloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol

Staphylococcus aureus

-

IC50: 50 nM

0.00026

2-[[2-(difluoromethoxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol

Staphylococcus aureus

-

IC50: 260 nM

0.000058

2-[[2-(prop-2-en-1-yloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol

Staphylococcus aureus

-

IC50: 58 nM

0.000025

3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)propanamide

Staphylococcus aureus

-

IC50: 25 nM

0.000036

3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]propanamide

Staphylococcus aureus

-

IC50: 36 nM

0.000058

3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]propanoic acid

Staphylococcus aureus

-

IC50: 58 nM

0.000026

4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)butanamide

Staphylococcus aureus

-

IC50: 26 nM

0.00003

4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]butanamide

Staphylococcus aureus

-

IC50: 30 nM

0.000043

4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butanoic acid

Staphylococcus aureus

-

IC50: 43 nM

0.00006 - 0.01

5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

show

0.0023 - 0.0049

BPP_03B04

show

0.001 - 0.059

ethyl [3-[3-(difluoromethyl)-1H-pyrazol-5-yl]phenoxy]acetate

show

0.00008 - 0.011

ethyl [3-[3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy]acetate

show

0.0014 - 0.08

N-(1,1-dioxo-1l6-thiolan-3-yl)-2-[(4-methylphenoxy)methyl]-1,3-thiazole-4-carboxamide

show

0.000008 - 0.00005

N-[2-(1H-indol-3-yl)ethyl]-3-[(1,3-thiazol-2-ylcarbamoyl)amino]benzenesulfonamide

show

0.0000022 - 0.000013

N-[2-(1H-indol-3-yl)ethyl]-3-[[(1,3-thiazol-2-yl)carbamoyl]amino]benzene-1-sulfonamide

show

0.00007 - 0.0042

N-[2-[1-(methanesulfonyl)cyclopropyl]ethyl]-2-[3-[3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy]acetamide

show

0.0000027 - 0.000022

N-[3-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]-N'-1,3-thiazol-2-ylurea

show

0.00012

N2-[[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetyl]-N-methylglycinamide

Staphylococcus aureus

-

IC50: 120 nM

0.000049

[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetonitrile

Staphylococcus aureus

-

IC50: 49 nM

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Release 2023.1 (January 2023)