6.1.1.19: arginine-tRNA ligase

This is an abbreviated version!
For detailed information about arginine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

Arg-tRNA synthetase, Arginine translase, Arginine--tRNA ligase, Arginine-tRNA synthetase, Arginyl transfer ribonucleic acid synthetase, Arginyl-transfer RNA synthetase, Arginyl-tRNA synthetase, arginyl�tRNA synthetase, ArgRS, ArgS2, MtArgRS, RARS, RARS2, RRS, Synthetase, arginyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.19 arginine-tRNA ligase

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Results	in table
7	Activating Compound
54070	AA Sequence
1	CAS Registry Number
28	Cloned(Commentary)
26	Cofactor
12	Crystallization (Commentary)
122	Disease/ Diagnostics
3	Expression
4	General Information
8	General Stability
2	IC50 Value
34	Inhibitors
12	kcat/KM [mM/s]
2	Ki Value [mM]
132	KM Value [mM]
9	Localization
15	Metals/Ions
30	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
291	Organism
4	Pathway
28	PDB ID
9	pH Optimum
1	pH Range
2	pI Value
2	Posttranslational Modification
33	Protein Variants
38	Purification (Commentary)
9	Reaction
8	Reaction Type
85	Reference
21	Source Tissue
21	Specific Activity [micromol/min/mg]
4	Storage Stability
103	Substrates and Products (Substrate)
26	Subunits
63	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
42	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.1.1.19 - arginine-tRNA ligase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + L-arginine + tRNAArg

?

Rattus norvegicus

-

the complexed enzyme supplies arginyl-tRNA for the protein synthesis

264

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl tRNAArg

Canavalia ensiformis

B2G3G6

-

694971

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

16 entries

additional information

?

-

3 entries

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Caenorhabditis elegans

Q19825

-

706759

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Canavalia ensiformis

B2G3G6

-

703633

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Caryedes brasiliensis

-

L-arginine is the best substrate

727625

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Escherichia coli

-

-

701542, 702060

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Escherichia coli

P11875

-

728718

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Glycine max

B6ETP1

-

703633

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Homo sapiens

-

-

715565

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Homo sapiens

P54136

-

744900, 745303

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Homo sapiens

-

-

745303

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Homo sapiens

P54136

-

745338, 746294

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Homo sapiens

-

the C-terminal extension of the human cytosolic leucyl-tRNA synthetase is indispensable for its interaction with the N-terminal of human cytosolic arginyl-tRNA synthetase in the macromolecular complex

662416

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Methanothermobacter thermautotrophicus

-

-

715636

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Plasmodium falciparum

Q8I5M2

-

746516

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Pyrococcus horikoshii

O59147

-

703658

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Rattus norvegicus

P40329

-

745485, 745486

-

-

?

ATP + L-arginine + tRNAArg

AMP + diphosphate + L-arginyl-tRNAArg

Saccharomyces cerevisiae

-

-

726863

-

-

?

additional information

?

-

Homo sapiens

-

key role in protein synthesis as part of a multienzyme complex

258

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus

-

arginyl-tRNA synthetase, MtArgRS, directly and stably interacts with seryl-tRNA synthetase, MtSerRS, EC 6.1.1.11, two-hybrid system and surface plasmon resonance analysis, overview. The MtSerRS-MtArgRS complex also contains tRNAArg, consistent with the existence of a stable ribonucleoprotein complex active in aminoacylation. Deletion of the HTH motif, which contributes to the stability of SerRS dimers, significantly weakens the interaction between the two synthetases. Stimulation by MtArgRS peaks at 65°C

715636

-

-

?

additional information

?

-

Rattus norvegicus

-

the free enzyme provides arginyl-tRNA for the NH2-terminal arginine modification of proteins by arginyl-tRNA:protein arginyltransferase, EC 2.3.2.8

264

-

-

?