6.1.1.18: glutamine-tRNA ligase
This is an abbreviated version!
For detailed information about glutamine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.18
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6.1.1.18
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synthetases
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aminoacyl-trna
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aminoacylation
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anticodon
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glutamyl-trna
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glutaminylation
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gln-trnagln
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noncognate
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aarss
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trna-dependent
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mischarging
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transamidation
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asnrs
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aspartyl-trna
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trna2gln
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nondiscriminating
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trnatyr
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misaminoacylation
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glurss
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misacylated
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ilers
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cysrs
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anticodon-binding
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valrs
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gatcab
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gln-trna
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drug development
- 6.1.1.18
- synthetases
- aminoacyl-trna
- aminoacylation
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anticodon
- glutamyl-trna
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glutaminylation
- gln-trnagln
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noncognate
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aarss
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trna-dependent
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mischarging
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transamidation
- asnrs
- aspartyl-trna
- trna2gln
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nondiscriminating
- trnatyr
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misaminoacylation
- glurss
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misacylated
- ilers
- cysrs
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anticodon-binding
- valrs
- gatcab
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gln-trna
- drug development
Reaction
Synonyms
class I glutaminyl-tRNA synthetase, cytosolic glutaminyl-tRNA synthetase, Gln-RS, Gln4, GlnRS, Glutamine translase, Glutamine--tRNA ligase, Glutamine-tRNA synthetase, glutaminyl tRNA synthetase, Glutaminyl-transfer ribonucleate synthetase, Glutaminyl-transfer RNA synthetase, Glutaminyl-tRNA synthetase, glutaminyltRNA synthetase, glutamyl/glutaminyl-tRNA synthetase, QARS, QRS, Synthetase, glutaminyl-transfer ribonucleate, Vegetative specific protein H4
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 6.1.1.18 - glutamine-tRNA ligase
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REACTION DIAGRAM
ATP + L-glutamate + tRNAGln
AMP + diphosphate + glutamyl-tRNAGln
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-
-
?
AMP + diphosphate + L-glutaminyl-tRNAGln
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-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
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-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
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-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
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-
-
r
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
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-
-
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r
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
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long-range intramolecular signaling in a tRNA synthetase complex
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-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
-
-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
Saccharomyces cerevisiae ATCC 204508 / S288c
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-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
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-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
Toxoplasma gondii ATCC 50611 / Me49
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-
-
?
ATP + L-glutamine + tRNAGln
AMP + diphosphate + L-glutaminyl-tRNAGln
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-
-
-
?
additional information
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eukaryotic GlnRS evolves from GluRS by gene duplication and horizontally transfers to bacteria
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-
?
additional information
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the enzyme interacts with the apoptosis signal-regulating kinase ASK1, which involves the active sites of the enzymes and inhibits AKS1, the association is mediated and enhanced by glutamine, it is inhibited by Fas ligation, the enzyme inhibits ASK1-induced apoptosis
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?