6.1.1.17: glutamate-tRNA ligase

This is an abbreviated version!
For detailed information about glutamate-tRNA ligase, go to the full flat file.

Reaction

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, D-GluRS, discriminating GluRS, EC 2.7.2.13, Ec-GluRS, EPRS, ERS, Ers2, GltX, GluRS, GluRS1, GluRS2, GluRSAt, Glutamate--tRNA ligase, Glutamate-tRNA synthetase, Glutamic acid translase, Glutamic acid tRNA ligase, Glutaminyl-tRNA synthetase, Glutamyl tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, glutamyl-Q tRNAASp synthetase, Glutamyl-transfer ribonucleate synthetase, Glutamyl-transfer ribonucleic acid synthetase, Glutamyl-transfer RNA synthetase, Glutamyl-tRNA synthetase, glutamyl-tRNAsynthetase, GtS, More, P85, surface-exposed glutamyl tRNA synthetase, TM1351, tRNA modifying enzyme, YadB

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.17 glutamate-tRNA ligase

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Results	in table
10	Activating Compound
54930	AA Sequence
2	Application
1	CAS Registry Number
38	Cloned(Commentary)
43	Cofactor
10	Crystallization (Commentary)
143	Disease/ Diagnostics
6	Expression
22	General Information
3	General Stability
2	IC50 Value
50	Inhibitors
14	kcat/KM [mM/s]
28	Ki Value [mM]
72	KM Value [mM]
20	Localization
43	Metals/Ions
33	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
589	Organism
9	Pathway
101	PDB ID
24	pH Optimum
2	pH Range
5	Posttranslational Modification
27	Protein Variants
32	Purification (Commentary)
11	Reaction
46	Reaction Type
121	Reference
20	Source Tissue
17	Specific Activity [micromol/min/mg]
3	Storage Stability
187	Substrates and Products (Substrate)
38	Subunits
140	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
32	Turnover Number [1/s]

Organism

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Organism on EC 6.1.1.17 - glutamate-tRNA ligase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acidithiobacillus ferrooxidans

3 entries

Aeropyrum pernix

-

653391

-

-

brenda

Arabidopsis thaliana

-

650292

O82462

SwissProt

brenda

Archaeoglobus fulgidus

-

653391

-

-

brenda

Babesia bovis

Mo7 biological clone

727429

A7AS98

UniProt

brenda

Bacillus subtilis

2 entries

Bacillus subtilis 168

Trp-

221, 228

-

-

brenda

Bacillus subtilis 168T

-

653867

-

-

brenda

Bos taurus

-

92

-

-

brenda

Caesalpinia bondue

-

214

-

-

brenda

Chlamydia trachomatis

non-discriminating enzyme form

440092

-

-

brenda

Chlamydomonas reinhardtii

-

199, 203, 208

-

-

brenda

Cyanidium caldarium

-

200

-

-

brenda

Escherichia coli

11 entries

Geobacillus stearothermophilus

-

198

-

-

brenda

Geobacillus stearothermophilus 168T

-

198

-

-

brenda

Helicobacter pylori

4 entries

Helicobacter pylori GluRS1

GluRS1

659722, 660346

-

-

brenda

Hemerocallis fulva

-

214

-

-

brenda

Homo sapiens

2 entries

Hordeum vulgare

-

203, 230

-

-

brenda

Methanobacterium thermoautotrophicus

-

728154

O26157

UniProt

brenda

Methanocaldococcus jannaschii

-

653391

-

-

brenda

Methanococcus thermoautotrophicum

-

653391

-

-

brenda

Methanosarcina mazei

-

653391

-

-

brenda

Methanothermobacter thermautotrophicus

-

728668

-

-

brenda

Mus musculus

2 entries

Mus musculus C57BL/6

-

745867

Q8CGC7

UniProt

brenda

Mycobacterium tuberculosis

-

703636

P9WFV9

Uniprot

brenda

Mycobacterium tuberculosis H37Rv

-

703636

P9WFV9

Uniprot

brenda

Oryctolagus cuniculus

enzyme has dual substrate specificity for L-glutamate and L-proline, enzyme is part of a large aminoacyl-tRNA synthetases complex

651917

-

-

brenda

Plasmodium falciparum

-

727963

-

-

brenda

Pseudomonas aeruginosa

-

745395

Q9XCL6

UniProt

brenda

Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1

-

745395

Q9XCL6

UniProt

brenda

Pyrococcus horikoshii

-

653391

-

-

brenda

Rattus norvegicus

-

127

-

-

brenda

Saccharolobus solfataricus

-

653391

-

-

brenda

Saccharomyces cerevisiae

2 entries

Saccharomyces cerevisiae ATCC 204508 / S288c

-

745552

P46655

SwissProt

brenda

Saccharomyces cerevisiae RS453

-

658101

-

-

brenda

Schizosaccharomyces pombe

-

702746

-

-

brenda

Sinorhizobium meliloti

2 entries

Streptococcus pneumoniae

several strains and cultivars, overview, gene gltX

675229

-

-

brenda

Tetradesmus obliquus

yellow pigment mutant C-2A'

231

-

-

brenda

Thermotoga maritima

-

713616

-

-

brenda

Thermotoga maritima TM1351

-

713616

-

-

brenda

Thermus thermophilus

5 entries

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

204, 225, 226

-

-

brenda

Tolypothrix sp.

strain PCC 7601, gene gltX

676062

-

-

brenda

Triticum aestivum

enzyme forms: GuRSP and GluRSE

223, 224

-

-

brenda

Trypanosoma brucei

-

659311

-

-

brenda

Vigna radiata var. radiata

-

214

-

-

brenda

Acidithiobacillus ferrooxidans

-

651337, 714031

-

-

brenda

Acidithiobacillus ferrooxidans

strain ATCC 23270, isoform 1 and 2, genes gltX1 and gltX2

651337

-

-

brenda

Acidithiobacillus ferrooxidans

strain ATCC 23270, two isozymes GluRS1 and GluRS2

676889

-

-

brenda

Bacillus subtilis

-

210, 492290, 492295, 651337, 653867

-

-

brenda

Bacillus subtilis

Trp-

221, 228

-

-

brenda

Escherichia coli

-

201, 210, 211, 212, 213, 215, 216, 217, 218, 219, 220, 232, 651050, 659591, 660375, 672564, 677107, 690792

-

-

brenda

Escherichia coli

-

702120

P04805

Uniprot

brenda

Escherichia coli

-

703714, 743955

-

-

brenda

Escherichia coli

-

744531, 746179

P04805

Uniprot

brenda

Escherichia coli

mutants encoding GluRS variants altered in the 98C-138C segment

206

-

-

brenda

Escherichia coli

overproducing strain DH5alpha(pLQ7612)

202

-

-

brenda

Escherichia coli

pure enzyme

650511

-

-

brenda

Escherichia coli

pure recombinant enzyme from overproducing strain DH5alpha

651055

-

-

brenda

Escherichia coli

strain MRE-600 and overproducing strain HS7611

227

-

-

brenda

Escherichia coli

the YadB protein displays 34% identity with the catalytic core of glutamy-tRNA synthetase but lacks the anticodon-binding domain

660030

-

-

brenda

Escherichia coli

yadB gene encodes a truncated GluRS that lacks the C-terminal third of the protein and, consequently the anticodon binding domain

660376

-

-

brenda

Helicobacter pylori

-

714451

-

-

brenda

Helicobacter pylori

GluRS1

659722, 660346

-

-

brenda

Helicobacter pylori

isoform GluRS2

705976

-

-

brenda

Helicobacter pylori

isozyme 2

651337

-

-

brenda

Homo sapiens

-

694123, 706514

-

-

brenda

Homo sapiens

-

745867

P07814

UniProt

brenda

Mus musculus

-

126, 659591, 745339

-

-

brenda

Mus musculus

-

745867

Q8CGC7

UniProt

brenda

Saccharomyces cerevisiae

-

207, 658101

-

-

brenda

Saccharomyces cerevisiae

-

671048, 676213, 745552

P46655

SwissProt

brenda

Sinorhizobium meliloti

-

196

-

-

brenda

Sinorhizobium meliloti

no glutaminyl-tRNA synthetase activity found in crude extract, but a specific aminotransferase activity that changes Glu-tRNAGln to Gln-tRNAGln

197

-

-

brenda

Thermus thermophilus

-

204, 225, 226

-

-

brenda

Thermus thermophilus

-

651000, 677157, 705182

P27000

Uniprot

brenda

Thermus thermophilus

discriminating enzyme form, purified recombinant enzyme from overexpressing Escherichia coli strain JM109(DE3)

653317

P27000

Uniprot

brenda

Thermus thermophilus

overexpressed in Escherichia coli

204

-

-

brenda

Thermus thermophilus

wild-type and mutant enzymes

204, 205, 209, 210, 225, 226, 229

-

-

brenda